期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 13, 页码 2231-2250出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0326-6
关键词
Microtubules; Mitotic motors; Mitotic spindle; Kinesins; Force-generation; Force-velocity relationships
资金
- NIH [GM 55507]
The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.
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