Review
Oncology
Ariana Cabrera-Licona, X. Isidro Perez-Anorve, Mauricio Flores-Fortis, Oscar del Moral-Hernandez, H. Claudia Gonzalez-de la Rosa, Rocio Suarez-Sanchez, Margarita Chavez-Saldana, Elena Arechaga-Ocampo
Summary: Radiotherapy, along with surgery and systemic chemotherapy, is crucial in the clinical management of cancer, but radioresistance remains a major challenge. Epigenetic mechanisms regulating cancer hallmarks play a key role in the development of radiation resistance, and targeting these mechanisms can enhance treatment effectiveness.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Lemeng Feng, Chao Wang, Cheng Zhang, Wulong Zhang, Weitao Song
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, and lowering intraocular pressure is currently the only effective clinical treatment. However, there is a lack of long-acting drugs to lower intraocular pressure, and some patients still experience loss of retinal ganglion cells despite good control of intraocular pressure. Currently, there are no effective clinical methods for neuroprotection and regeneration in glaucoma. Recent studies have shown that epigenetics plays a crucial role in neuroprotection and regeneration in glaucoma.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Klaudia Dopytalska, Piotr Ciechanowicz, Kacper Wiszniewski, Elzbieta Szymanska, Irena Walecka
Summary: Psoriasis is a chronic immune-mediated disease with approximately 2% incidence. Genetic and environmental factors play significant roles in its pathogenesis. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, are highlighted for their role in the etiology and pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Tianyou Liu, Dongru Du, Rui Zhao, Qinglian Xie, Zaiquan Dong
Summary: Central nervous system (CNS) disorders, such as depression, anxiety, and Alzheimer's disease (AD), have a significant impact on patients' quality of life and pose economic and social burdens worldwide. The gut microbiome has been found to influence the CNS at both the structural and functional levels, as well as through epigenetic processes. Understanding the tripartite relationship among gut microbiota, epigenetic inheritance, and CNS disorders may lead to the development of more effective therapeutic strategies.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biology
Ranjith K. Papareddy, Katalin Paldi, Anna D. Smolka, Patrick Huther, Claude Becker, Michael D. Nodine
Summary: MicroRNA-mediated repression of CHROMOMETHYLASE 3 (CMT3) and the chromatin features preferred by CMT3 help prevent ectopic methylation of thousands of genes during embryogenesis, potentially avoiding harmful effects for weeks afterwards.
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Cell Biology
Luke Twenhafel, DiAnna Moreno, Trista Punt, Madeline Kinney, Rebecca Ryznar
Summary: Osteosarcoma is a common malignant bone tumor in children and adolescents. Despite improvements in clinical outcomes, early detection is crucial for better survival rates and reducing the need for debilitating treatments like amputations. Research in the field of epigenetics, focusing on changes in genetic expression above the genome, shows potential for understanding and improving the treatment of osteosarcoma.
Article
Obstetrics & Gynecology
Hong Chen, Maira Bianchi Rodrigues Alves, Clemence Belleannee
Summary: Epididymal epithelial cells and EVs play crucial roles in sperm maturation, with recent discoveries of immune cell populations and epididymal cell extensions providing a more comprehensive understanding of the sperm's surrounding environment.
HUMAN REPRODUCTION UPDATE
(2022)
Review
Biochemistry & Molecular Biology
Phanikanth Jogam, Dulam Sandhya, Anshu Alok, Venkataiah Peddaboina, Venkateswar Rao Allini, Baohong Zhang
Summary: Epigenetic changes refer to heritable modifications in genes without altering DNA sequences, commonly occurring in plant genomes to regulate gene expression patterns for different biological processes. Gene engineering for stress-tolerant crops via DNA methylation pathway requires tools such as ZFN, TALENs, and CRISPR/Cas. CRISPR/Cas9 mediated epigenetic editing involves transcriptional reprogramming at targeted sites using epigenetic enzymes fused with dCas9.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Stefan Harsanyi, Zuzana Varchulova Novakova, Katarina Bevizova, Lubos Danisovic, Stanislav Ziaran
Summary: Bladder cancer is the 10th most common cancer worldwide, with a variety of diagnostic methods available, including standard cystoscopy and urine cytology. Liquid biopsy as a new trend is proving to be almost equally effective in detecting bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Jose Luis Garcia-Gimenez, Salvador Mena-Molla, Francisco Jose Tarazona-Santabalbina, Jose Vina, Mari Carmen Gomez-Cabrera, Federico V. Pallardo
Summary: As individuals age, epigenetic features change and can lead to decreased physiological reserves, dysregulation of multiple physiological systems, and adverse health outcomes for individuals of the same chronological age. Discovering and utilizing biomarkers for frailty could aid in accurately diagnosing frailty and predicting the health trajectories of older adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Alexandros Pergaris, Kleio Vrettou, Stamatios Theocharis, Constantinos Troungos
Summary: Thymic Epithelial Neoplasms (TENs) are commonly observed tumors in the thymus gland. Epigenetic modifications, including non-coding RNA clusters and altered gene methylation, are implicated in the tumorigenesis of TENs and may serve as potential biomarkers. Histone Deacetylase Inhibitors have shown promising antitumor effects in clinical trials and could be effective epigenetic therapeutic agents for TENs. However, further studies in larger patient cohorts are required to validate the clinical utility and safety of novel epigenetic agents in the treatment of TENs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Jana Svorcova
Summary: In recent years, increasing evidence suggests the non-genetic heredity of the effects of separation from parents, life-threatening events, and other traumatising experiences. This heredity is mediated by epigenetic regulations and can be transmitted over generations. The reviewed studies on transgenerational epigenetic inheritance (TEI) and intergenerational studies on trauma or stressful experiences reveal universal changes initiated by stress exposure at various levels of organization. Understanding these processes can help elucidate the evolutionary pathways of diseases and disorders associated with trauma exposure.
Review
Chemistry, Medicinal
Pia Loren, Nicolas Saavedra, Kathleen Saavedra, Tomas Zambrano, Patricia Moriel, Luis A. Salazar
Summary: Cisplatin, an antineoplastic drug, is most notably known for its nephrotoxicity among various side effects. Recent research shows that epigenetic regulation plays a key role in cisplatin-induced nephrotoxicity by altering different signaling pathways leading to cell death. Despite the ongoing development in this field, it offers new strategies for the diagnosis and treatment of diseases.
Review
Biochemistry & Molecular Biology
Li Wen, Hong-Liu Yang, Lin Lin, Liang Ma, Ping Fu
Summary: This review highlights the role of epigenetic methylation in kidney disease and discusses the regulation and implication of DNA methylation, histone methylation, and non-histone methylation in various forms of kidney diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)