期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 17, 页码 2957-2968出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0391-x
关键词
Notch signaling; CBF1-independent Notch; Hes-1; Non-canonical Notch; Neural differentiation; Tumorigenesis
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.
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