期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 24, 页码 4249-4256出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0441-4
关键词
EBV; VDR; Transcription regulation; EBNA; Vitamin D3
资金
- Swedish Cancer Society
- Concern Foundation (Los Angeles)
- Cancer Research Institute (New York)
- Swedish Institute
- Swedish Foundation for Strategic Research
Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.
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