Review
Biochemistry & Molecular Biology
Alexander Y. Tsygankov
Summary: The UBASH3/STS/TULA protein family plays critical roles in regulating key biological functions, such as immunity and hemostasis, in mammalian systems. The TULA-family proteins negatively regulate signaling through immune receptor tyrosine-based activation motif (ITAM)- and hemITAM-bearing receptors, mainly through their protein tyrosine phosphatase (PTP) activity. However, they may also carry out PTP-independent functions. This review discusses the protein structure, enzymatic activity, molecular regulation mechanisms, and biological functions of TULA-family proteins, and examines the comparative analysis of TULA proteins in different metazoan taxa to identify potential roles outside of mammalian systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anika Zaman, Jarrod B. French, Nick Carpino
Summary: The Sts proteins, Sts-1 and Sts-2, play important roles in regulating signaling pathways. Sts-1 possesses protein tyrosine phosphatase activity and is involved in regulating multiple signaling pathways. Sts-2 has lower catalytic activity and its signaling role is less studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hyeon-Ah Do, Kwang-Hyun Baek
Summary: This study revealed that USP7 is a deubiquitinating enzyme of PP2A, regulating the ubiquitination and stability of PP2A through K48-linked polyubiquitin chains.
Review
Biochemistry & Molecular Biology
Satya P. Kunapuli, Alexander Y. Tsygankov
Summary: The members of the UBASH3/TULA/STS-protein family play critical regulatory roles in cellular processes. TULA-2 serves as a negative regulator of platelet signaling, downregulating the biological responses of platelets to agonists.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Weiming Ouyang, David M. Frucht
Summary: This study reveals that the Erk1/2 inactivation-triggered and COP1-mediated c-Jun degradation is regulated by protein phosphatases, UBE2 enzymes, and an intrinsic motif of c-Jun. The C-terminus of c-Jun protein plays a critical role in facilitating its degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Tsang-Wei Matt Chen, Yuki Tanaka, Yohei Kametani, Kum-Yi Cheng, Chih-Hsun Lin, Yi Rick Lin, Ting-Rong Hsu, Zuqian Chen, Jiping Hao, Shigeki Mori, Yoshihito Shiota, Kazunari Yoshizawa, Hiroyuki Furuta, Soji Shimizu, Chun-Hsien Chen
Summary: This study scrutinizes the spontaneous assembly of antiaromatic compounds at the liquid-solid interface using scanning tunneling microscopy (STM). The research reveals the polymorphism in monolayers characterized by orthogonal and parallel assemblies at different concentrations. The parallel assembly is found to be more stable and dominantly formed at higher concentrations. Moreover, the narrowing of the HOMO-LUMO gap suggests significant molecular orbital interactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Bu Wang, Fang Zou, Gu Xin, Bao-Li Xiang, Jian-Qing Zhao, Sheng-Fang Yuan, Xiu-Long Zhang, Zhi-Hua Zhang
Summary: This study found that sodium tanshinone IIA sulphate (STS) extracted from Salvia miltiorrhiza Bunge has an anti-tumor effect on lung adenocarcinoma, inhibiting cell proliferation, migration, invasion, and angiogenesis. This effect may be mediated by the miR-874/eEF-2K/TG2 pathway. STS could be a promising drug to fight against lung cancer and effectively reverse drug resistance when combined with classical anticancer drugs.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Virology
Nur Tukhanova, Anna Shin, Nurkeldi Turebekov, Talgat Nurmakhanov, Karlygash Abdiyeva, Alexandr Shevtsov, Toktasyn Yerubaev, Gulnara Tokmurziyeva, Almas Berdibekov, Vitaliy Sutyagin, Nurbek Maikanov, Andrei Zakharov, Ilmars Lezdinsh, Lyazzat Yeraliyeva, Guenter Froeschl, Michael Hoelscher, Stefan Frey, Edith Wagner, Lukas Peintner, Sandra Essbauer
Summary: This study investigated the presence of orthohantaviruses in small mammals in Kazakhstan. A small percentage of samples tested positive for orthohantavirus RNA, with Tula virus detected in West Kazakhstan and Almaty region. The geographical distribution of Tula virus was found to be more extensive than previously thought.
Article
Cell Biology
Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan, Ying Li
Summary: Activation of TNFR1 by TNF alpha leads to the formation of complex I, which plays a crucial role in determining cell fate. This study identifies PP6 as a component of complex I and shows that it regulates cell death through its phosphatase activity and regulatory subunits. Mechanistic studies reveal that PP6 modulates LUBAC-mediated ubiquitination to promote RIPK1 activation and c-FLIPL degradation. Loss of PP6 due to melanoma-related mutations confers resistance to cell death and promotes cancer progression.
CELL DEATH & DISEASE
(2022)
Letter
Immunology
Joerg Hofmann, Stephanie Kramer, Klaus R. Herrlinger, Kathrin Jeske, Martin Kuhns, Sabrina Weiss, Rainer G. Ulrich, Detlev H. Krueger
Summary: We report the molecular evidence of Tula virus infection in an immunocompetent patient from Germany, showing typical signs of hantavirus disease. Despite being considered nonpathogenic, accumulating evidence suggests that Tula virus infection poses a threat to human health.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie J. Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L. Williams, Marcus Thelen, David R. Powell, Markus Schueler, Michael S. Wiesener, Tamas Balla, Hagit N. Baris, Dov Tiosano, Brian M. McDermott, Brian D. Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A. Buchner, Emilio Hirsch
Summary: The cytokinetic process in the lens, which depends on PI3K-C2alpha, PI(3,4)P-2, and VPS36, is essential for preventing premature senescence and cataract. Loss of these components impairs cytokinesis and leads to cell damage, triggering senescence in the lens of fish, mice, and humans.
Article
Cell Biology
Yosuke Ogura, Kentaro Sahashi, Tomoki Hirunagi, Madoka Iida, Takaki Miyata, Masahisa Katsuno
Summary: Spinal and bulbar muscular atrophy (SBMA) is an adult-onset neurodegenerative disease caused by the expansions of CAG repeats in the androgen receptor (AR) gene. This study found that upregulation of Mid1 gene expression in motor neurons contributes to vulnerability and axonogenesis defects in SBMA.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ke Wang, Yanping Yu, Wei Wang, Yu Jiang, Yunlong Li, Xunliang Jiang, Yihuan Qiao, Le Chen, Xinhui Zhao, Jun Liu, Angang Yang, Jipeng Li, Rui Zhang
Summary: This study found different levels of IGF1R dependency in gastric cancer cells. Knockdown of NEDD4 significantly suppressed tumor growth in IGF1R-dependent gastric cancer cells, while it had no effect on IGF1R-independent cells. Additionally, high expression of NEDD4 and IGF1 predicted a worse prognosis in gastric cancer patients. Targeting NEDD4 may be a promising therapeutic strategy for IGF1 signal pathway-driven gastric cancer.
Article
Biochemistry & Molecular Biology
Yan Ma, Haibo Zhang, Cheng Chen, Lixin Liu, Ting Ding, Ying Wang, Dachang Ma, Xiaoling Ling, Xiaohua Chen, Jianping Li, Guansheng Zhong, Guoqing Ru, Lei Zhang, Jianming Tang
Summary: This study reveals that TRIM32 is upregulated and negatively associated with survival of TNBC patients. Radiotherapy enhances the expression of TRIM32, while depletion of TRIM32 reduces TNBC radioresistance. Mechanistically, radiotherapy promotes the association between TRIM32 and nuclear STAT3, which suppresses TC45-induced dephosphorylation of STAT3, resulting in increased STAT3 transcriptional activation and TNBC radioresistance. TRIM32 and STAT3 phosphorylation are co-expressed in TNBC tissues and correlated with poor prognosis of TNBC patients.
Review
Biochemistry & Molecular Biology
Barbara Hayes, Peter van der Geer
Summary: STS-1 and STS-2 are a small family of proteins involved in regulating protein-tyrosine kinase signal transduction. They have UBA, esterase, SH3, and PGM domains. The UBA and SH3 domains are used to modify protein-protein interactions, while the PGM domain catalyzes protein-tyrosine dephosphorylation. This manuscript discusses the proteins that interact with STS-1 or STS-2 and the experiments used to uncover these interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
