期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 23, 页码 3675-3684出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0097-0
关键词
Sox factor; SoxB1 member; ES cells; iPS cells; Neural stem cells; Human eye disorder
资金
- Ministry of Education, Science, Sports, Science and Technology
SoxB1 factors, which include Sox1, 2, and 3, share more than 90% amino acid identity in their DNA binding HMG box and participate in diverse developmental events. They are known to exert cell-type-specific functions in concert with other transcription factors on Sox factor-dependent regulatory enhancers. Due to the high degree of sequence similarity both within and outside the HMG box, SoxB1 members show almost identical biological activities. As a result, they exhibit strong functional redundancy in regions where SoxB1 members are coexpressed, such as neural stem/progenitor cells in the developing central nervous system.
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