期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 16, 页码 2528-2540出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8095-1
关键词
neutrophils; inflammation; chemotaxis; puringeric receptors; tissue damage
资金
- National Institute of General Medical Sciences [R01 GM-51477, GM-60475]
- CDMRP [PR043034]
Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected and inflamed sites. However, excessive influx of PMN damages host tissues. Better knowledge of the mechanisms that control PMN chemotaxis may lead to improved treatments of inflammatory diseases. Recent findings suggest that ATP and adenosine are involved in PMN chemotaxis. Therefore, these purinergic signaling processes may be suitable targets for novel therapeutic approaches to ameliorate host tissue damage.
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