期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 23, 页码 3789-3808出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8305-x
关键词
Proliferating cell nuclear antigen; proteomics; interaction; functions
资金
- National Cancer Institute of Canada (NCIC) [016072]
- Canadian Institutes of Health Research (CIHR) [MOP-57706]
Proliferating cell nuclear antigen (PCNA), a cell cycle marker protein, is well known as a DNA sliding clamp for DNA polymerase delta and as an essential component for eukaryotic chromosomal DNA replication and repair. Due to its mobility inside nuclei, PCNA is dynamically presented in a soluble or chromatin-associated form. The heterogeneity and specific modifications of PCNA may reflect its multiple functions and the presence of many binding partners in the cell. The recent proteomics approaches applied to characterizing PCNA interactions revealed multiple PCNA partners with a wide spectrum of activity and unveiled the possible existence of new PCNA functions. Since more than 100 PCNA-interacting proteins and several PCNA modifications have already been reported, a proteomics point of view seems exactly suitable to better understand the role of PCNA in cellular functions.
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