期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 12, 页码 1796-1805出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8153-8
关键词
galanin receptor ligands; therapeutics; drug treatment; neuropeptides; G-protein-coupled receptors
资金
- NIMH NIH HHS [MH074055-01, R01MH63080-05] Funding Source: Medline
Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3. Over the past decade, some of the receptor subtype-specific effects have been elucidated through pharmacological studies using subtype selective ligands, as well as through molecular approaches involving knockout animals. In the present review, we summarize the current data which constitute the basis of targeting GalR1, GalR2 and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据