期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 12, 页码 1836-1841出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8158-3
关键词
Alzheimer's; fear conditioning; learning and memory; Morris water maze; receptor knockout mice; social transmission of food preference; transgenic mice
资金
- Intramural NIH HHS [Z01 MH002177-22] Funding Source: Medline
The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据