Article
Biochemistry & Molecular Biology
Giuseppe Forte, Valentina Giuffrida, Angelica Scuderi, Mariella Pazzaglia
Summary: Neuropathic pain is a common chronic condition that severely affects patients with spinal cord injuries. Current treatment options are limited, but nanomedicine shows potential for improving therapeutic efficacy. However, its application in treating neuropathic pain following spinal cord injuries still needs further improvement.
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
John E. Gilbert, Tianhe Zhang, Rosana Esteller, Warren M. Grill
Summary: Temporal patterns of spinal cord stimulation designed using a computational model could effectively inhibit pain-related neuronal activity and potentially increase the efficacy of spinal cord stimulation.
Article
Public, Environmental & Occupational Health
Eva Widerstrom-Noga, Kimberly D. Anderson, Linda E. Robayo, Salome Perez, Alberto Martinez-Arizala, Lindsey Calle-Coule, Nicholas P. Cherup, Gabriel E. Fernandez
Summary: Many people with spinal cord injury (SCI) suffer from chronic pain, including neuropathic pain, which is often difficult to treat due to its complex nature. A multimodal approach, involving pharmacological treatments, physical rehabilitation, cognitive training, and pain education, may be the most effective strategy for managing pain in this population. This study developed an educational resource called SeePain, which was evaluated and modified based on stakeholder input, including SCI patients, their loved ones, and healthcare providers. The final resource is a comprehensive guide intended to improve health literacy and enhance communication between SCI patients and their healthcare providers. Future research will validate the effectiveness of SeePain using a large sample of SCI patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Neurosciences
Simin Tang, Huan Jing, Fuhu Song, Haicheng Huang, Wenjun Li, Guiling Xie, Jun Zhou
Summary: The study explores the role of microRNAs in neuropathic pain, specifically how miR-124 reverses NP by maintaining microglia quiescent, and miR-155 promotes NP by activating microglia. These findings provide insights for basic research and potential clinical treatments for neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell & Tissue Engineering
Yang Zhang, Xiang Xu, Yuxin Tong, Xijie Zhou, Jian Du, In Young Choi, Shouwei Yue, Gabsang Lee, Blake N. Johnson, Xiaofeng Jia
Summary: The study demonstrated that NCSC-laden nerve scaffolds helped alleviate neuropathic pain and enhance motor function recovery in rats with sciatic nerve injuries. Furthermore, NCSCs were found to protect the spinal cord from glial cell activation and central sensitization induced by nerve injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Zhihao Zhang, Zhijie Zhu, Xiaoshuang Zuo, Xuankang Wang, Cheng Ju, Zhuowen Liang, Kun Li, Jiawei Zhang, Liang Luo, Yangguang Ma, Zhiwen Song, Xin Li, Penghui Li, Huilin Quan, Peipei Huang, Zhou Yao, Ning Yang, Jie Zhou, Zhenzhen Kou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu Hu
Summary: This study investigated the mechanisms of photobiomodulation (PBM) in relieving neuropathic pain (NP) after spinal cord injury (SCI). It was found that PBM therapy inhibited the activation of microglia and astrocytes, decreased the expression of CXCL10 in glial cells, and mediated the NF-κB signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Jesse K. Niehaus, Bonnie Taylor-Blake, Lipin Loo, Jeremy M. Simon, Mark J. Zylka
Summary: Peripheral nerve injury leads to long-term pro-inflammatory responses in spinal cord glial cells, but the identity of endogenous cells that resolve spinal inflammation has not been determined. Our study demonstrates that MRC1(+) spinal cord macrophages actively restrain glia to limit neuroinflammation and resolve mechanical pain following superficial injury, suggesting that therapeutic modulation of spinal macrophages could promote long-lasting recovery of neuropathic pain.
Review
Anesthesiology
Jo Ann Shoup, JoEllen Welter, Ingrid A. Binswanger, Florian Hess, Alexander Dullenkopf, Jennifer Coker, Jeffrey Berliner
Summary: This scoping review analyzed research findings on the use of prescription opioids in patients with spinal cord injury (SCI), identifying a lack of information on income, ethnicity, and race in most studies. Risk factors for opioid use in chronic SCI included middle age, lower income, osteoarthritis diagnosis, prior opioid use, and lower-level spinal injury.
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Food Science & Technology
Garima Mishra, Pradeep Singh, Mulugeta Molla, Yohannes Shumet Yimer, Amien Ewunetie, Tesfaye Yimer Tadesse, Teklie Mengie Ayele, Belayneh Kefale
Summary: Distinguishing between neuropathy and fibromyalgia for adequate care is difficult. These pain syndromes have become a significant challenge for healthcare experts due to their complex etiology and limited drug availability. Patients seeking relief from chronic pain conditions have turned to nutraceuticals as an alternative, but research on their safety and efficacy is lacking.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Neurosciences
Chang Sun, Junhao Deng, Yifei Ma, Fanqi Meng, Xiang Cui, Ming Li, Jiantao Li, Jia Li, Pengbin Yin, Lingjie Kong, Licheng Zhang, Peifu Tang
Summary: This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following spinal cord injury (SCI). It delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. The article also provides a thorough overview of potential avenues for future research in this area.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Medicine, General & Internal
Dominika Mech, Katarzyna Korgol, Antonina Kurowska, Bartlomiej Adamski, Malgorzata Miazga, Grazyna Biala, Marta Kruk-Slomka
Summary: Spinal cord injury is a neurological condition that causes significant motor dysfunction, and current treatments only provide moderate efficacy, leaving patients with long-term disabilities. A scientific review is needed to summarize recent developments in therapeutic methods for SCI. This review focuses on pharmacological treatments and the challenges faced by patients depending on the location of the injury, addressing issues such as spasticity, neuropathic pain, neuroprotection, neurotransmission, and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Sajad Fakhri, Fatemeh Abbaszadeh, Masoumeh Jorjani
Summary: This study discusses the molecular mechanisms and therapeutic targets for post-SCI pain, focusing on critical signaling pathways that could provide new insights into the clinical treatment of post-SCI pain.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Jing Zhu, Fei Huang, Yonglin Hu, Wei Qiao, Yingchao Guan, Zhi-Jun Zhang, Su Liu, Ying Liu
Summary: Secondary chronic neuropathic pain (NP) after spinal cord injury (SCI) significantly reduces quality of life. The mechanisms of NP in SCI have been studied, and reducing neuroinflammation has shown potential for improving NP-related behaviors. Non-coding RNAs have been found to play important roles in SCI, regulating gene expression, inhibiting inflammation, and influencing the prognosis of NP.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
