How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors

Integrin-Generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions

(2014) Carol Jurchenko et al.   BIOPHYSICAL JOURNAL

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

(2014) Danfeng Cai et al.   CELL

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Tension-Sensitive Actin Assembly Supports Contractility at the Epithelial Zonula Adherens

(2014) Joanne M. Leerberg et al.   CURRENT BIOLOGY

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

(2014) Sei Kuriyama et al.   JOURNAL OF CELL BIOLOGY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Mechanical control of the sense of touch by β-spectrin

(2014) Michael Krieg et al.   NATURE CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

A DNA-based molecular probe for optically reporting cellular traction forces

(2014) Brandon L Blakely et al.   NATURE METHODS

Optical manipulation of single molecules in the living cell

(2014) Kamilla Norregaard et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traction force microscopy in physics and biology

(2014) Robert W. Style et al.   Soft Matter

Interrogating Biology with Force: Single Molecule High-Resolution Measurements with Optical Tweezers

(2013) Marco Capitanio et al.   BIOPHYSICAL JOURNAL

Mechano-Gated Ion Channels in Sensory Systems

(2013) Patrick Delmas et al.   CELL

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Förster resonance energy transfer microscopy and spectroscopy for localizing protein-protein interactions in living cells

(2013) Yuansheng Sun et al.   CYTOMETRY PART A

Advances in magnetic tweezers for single molecule and cell biophysics

(2013) Devrim Kilinc et al.   Integrative Biology

Vinculin tension distributions of individual stress fibers within cell-matrix adhesions

(2013) C.-W. Chang et al.   JOURNAL OF CELL SCIENCE

Tension Sensing Nanoparticles for Mechano-Imaging at the Living/Nonliving Interface

(2013) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Tension Sensors Report Forces Generated by Single Integrin Molecules in Living Cells

(2013) Masatoshi Morimatsu et al.   NANO LETTERS

Quantifying cell-generated mechanical forces within living embryonic tissues

(2013) Otger Campàs et al.   NATURE METHODS

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening

(2013) N. Hersch et al.   Biology Open

Quantitative Intensity-Based FRET Approaches—A Comparative Snapshot

(2012) André Zeug et al.   BIOPHYSICAL JOURNAL

Engineering strain-sensitive yellow fluorescent protein

(2012) Taro Ichimura et al.   CHEMICAL COMMUNICATIONS

Force as a single molecule probe of multidimensional protein energy landscapes

(2012) Gabriel Žoldák et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Orientation-based FRET sensor for real-time imaging of cellular forces

(2012) F. Meng et al.   JOURNAL OF CELL SCIENCE

Interplay between Cytoskeletal Stresses and Cell Adaptation under Chronic Flow

(2012) Deepika Verma et al.   PLoS One

GFP's Mechanical Intermediate States

(2012) John Saeger et al.   PLoS One

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use the force: membrane tension as an organizer of cell shape and motility

(2012) Alba Diz-Muñoz et al.   TRENDS IN CELL BIOLOGY

Real-time observation of flow-induced cytoskeletal stress in living cells

(2011) Jason Rahimzadeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

(2011) Kimihide Hayakawa et al.   JOURNAL OF CELL BIOLOGY

Mechanical Load Induces a 100-Fold Increase in the Rate of Collagen Proteolysis by MMP-1

(2011) Arjun S. Adhikari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing mechanical tension across membrane receptors with a fluorescent sensor

(2011) Daniel R Stabley et al.   NATURE METHODS

Imaging proteins inside cells with fluorescent tags

(2011) Georgeta Crivat et al.   TRENDS IN BIOTECHNOLOGY

Real Time FRET Based Detection of Mechanical Stress in Cytoskeletal and Extracellular Matrix Proteins

(2010) Fanjie Meng et al.   Cellular and Molecular Bioengineering

Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor

(2010) F. Meng et al.   JOURNAL OF CELL SCIENCE

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Quantitative Comparison of Different Fluorescent Protein Couples for Fast FRET-FLIM Acquisition

(2009) Sergi Padilla-Parra et al.   BIOPHYSICAL JOURNAL

Practical and reliable FRET/FLIM pair of fluorescent proteins

(2009) Dmitry Shcherbo et al.   BMC BIOTECHNOLOGY

The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion

(2009) Andrew F. Powers et al.   CELL

Force and function: probing proteins with AFM-based force spectroscopy

(2009) Elias M Puchner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Catch Bonds in Adhesion

(2008) Wendy Thomas   Annual Review of Biomedical Engineering

Biophysics of Catch Bonds

(2008) Wendy E. Thomas et al.   Annual Review of Biophysics

A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ

(2008) Fanjie Meng et al.   FEBS Journal

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualizing myosin-actin interaction with a genetically-encoded fluorescent strain sensor

(2008) S. Iwai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA