Article
Pharmacology & Pharmacy
Wan-Jiao Gao, Jian-Xin Liu, Yie Xie, Pei Luo, Zhong-Qiu Liu, Liang Liu, Hua Zhou
Summary: A large number of macrophages in inflamed sites can exacerbate inflammatory responses, while Sinomenine can exert its anti-inflammatory effects by inhibiting macrophage migration. Sinomenine can also alleviate inflammation and prevent macrophage infiltration.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Maria-Graciela Delgado, Ana-Maria Lennon-Dumenil
Summary: Migration of immune cells is crucial for building an efficient defense system, playing important roles from early development to tissue patrolling and lymph node migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
R. S. Seelan, P. Mukhopadhyay, J. Philipose, R. M. Greene, M. M. Pisano
Summary: Folate receptor 1 (Folr1) deficiency may cause embryonic developmental abnormalities and affect important biological processes such as cellular proliferation, apoptosis, and migration. Under folate-deficient conditions, cranial neural crest cells and neural tube explants showed a significant reduction in directed migration, partly due to alterations in cell skeleton.
Article
Physics, Multidisciplinary
Guanming Zhang, Julia M. Yeomans
Summary: We studied the influence of intercellular active forces on individual cell morphology and collective motion in a cell monolayer using a computational phase-field model and analytical analysis. We focused on the regime where intercellular forces dominate tissue dynamics and polar forces are negligible. Our results showed that contractile intercellular interactions lead to cell elongation and nematic ordering, resulting in active turbulence with motile topological defects. On the other hand, extensile interactions resulted in frustration and increased prevalence of perpendicular cell orientations. Furthermore, we found that contractile behavior can transition to extensile behavior when considering anisotropic fluctuations in cell shape.
PHYSICAL REVIEW LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Hiroyuki Tada, Takashi Nishioka, Rina Ishiyama, Li-Ting Song, Sakura Onoue, Kazuyoshi Kawahara, Eiji Nemoto, Kenji Matsushita, Shunji Sugawara
Summary: In this study, the effects of mast cell extracellular traps (MCETs) released from mast cells after infection with periodontal pathogen Fusobacterium nucleatum were investigated. F. nucleatum induced the release of MCETs from mast cells, and these MCETs expressed macrophage migration inhibitory factor (MIF). Importantly, MIF bound to MCETs induced the production of proinflammatory cytokines by monocytic cells. These findings suggest that MIF expressed on MCETs released upon infection with F. nucleatum promotes inflammatory responses associated with the pathogenesis of periodontal disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Summary: DSCAMs are involved in various neurodevelopmental processes, and their malfunction can lead to disorders such as Fragile X syndrome, intellectual disability, autism, and bipolar disorder. While Dscam and Dscaml1 knockout did not significantly affect developmental events in mice, gain of function experiments showed negative impacts on neural migration processes important for cortical development. This highlights the importance of genes encoding adhesive cues in neuronal migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L. Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman
Summary: Local cell therapy using mesenchymal stem cells (MSCs) has gained attention for treating joint diseases and fractures. This study investigated the utility of C-C motif chemokine ligand 2 (CCL2) as a therapeutic target for this therapy. The results showed that overexpression of CCL2 promoted macrophage chemotaxis and osteogenesis, as well as angiogenesis, through crosstalk between MSCs and macrophages. These findings suggest that CCL2 may be a useful target for local cell therapy in areas of bone loss.
Review
Immunology
Jasna Friscic, Markus H. Hoffmann
Summary: Fibroblasts, which are tissue resident mesenchymal cells, have been found to play a crucial role in the pathology of immune-mediated inflammatory diseases. They are derived from universal pan organ cellular ancestors and differentiate into specific subsets based on the functional needs of their respective tissues and their activation state. In arthritis, various types of activated joint-resident and migrating fibroblasts have been identified as central to the pathogenesis and persistence of the inflammatory joint disease. This paper provides an overview of the inflammatory and immune related functions of fibroblasts and discusses strategies to control these functions for long-lasting disease relief.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Moon Young Jun, Rajendra Karki, Keshav Raj Paudel, Nisha Panth, Hari Prasad Devkota, Dong-Wook Kim
Summary: Liensinine showed significant anti-oxidative activity by inhibiting serum lipid peroxidation and reducing NO generation in macrophage cells. It also suppressed proliferation and enzymatic activity in vascular smooth muscle cells as well as expression of inflammatory markers. These findings suggest the potential preventive effect of liensinine on vascular inflammation.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Hong-Xia Mei, Yang Ye, Hao-Ran Xu, Shu-Yang Xiang, Qian Yang, Hong-Yu Ma, Sheng-Wei Jin, Qian Wang
Summary: LXA4 inhibits the production of TNF-alpha and IL-1 beta induced by LPS, and regulates macrophage recruitment dependent on CCL2 secretion by resident macrophages. It protects lung tissue from neutrophil recruitment through the CXCL2/MMP-9 signaling pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kurmanbek Kaiyrbekov, Kirsten Endresen, Kyle Sullivan, Zhaofei Zheng, Yun Chen, Francesca Serra, Brian A. Camley
Summary: Collective movement and organization of cell monolayers are crucial for wound healing and tissue development. Recent experiments have emphasized the significance of liquid crystal order in these layers, suggesting that +1 topological defects play a role in organizing tissue morphogenesis. In our study, we investigate fibroblast organization, motion, and proliferation on a substrate with micron-sized ridges that induce +1 and -1 topological defects using simulation and experiment. Our findings indicate that density variation near defects cannot be explained by collective migration, instead suggesting that fibroblasts have different division rates depending on their area and aspect ratio. This work provides insights into tissue patterning using topological defects without relying on cell migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Runchen Zhao, Siqi Cui, Zhuoxu Ge, Yuqi Zhang, Kaustav Bera, Lily Zhu, Sean X. Sun, Konstantinos Konstantopoulos
Summary: Cells transitioning from amoeboid to mesenchymal phenotypes in response to increasing hydraulic resistance exhibit oscillatory changes in actin network formation and focal adhesion maturation. Blocking the mechanosensor TRPM7 eliminates the dependence of transition period on resistance, and mathematical modeling reveals the role of intracellular calcium oscillations in this process. Hydraulic resistance emerges as a critical physical factor influencing cell phenotype, with a proposed framework for linking fluorescence signal fluctuations to morphological changes.
Article
Gastroenterology & Hepatology
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei
Summary: Using single-cell RNA sequencing, a distinct inflammation-associated subset of MSCs, AIF1(+)CSF1R(+) MSCs, was identified in the microenvironment before liver cancer occurrence. In a rat primary liver cancer model, MSCs with high SIRT1 expression promoted liver cancer occurrence by secreting CCL5 and recruiting macrophages. Furthermore, SIRT1 was shown to up-regulate CCL5 expression in MSCs through activation of the AKT/HIF1 alpha signaling axis.
Article
Oncology
Bareun Kim, Anthony T. Lopez, Indhujah Thevarajan, Maria F. Osuna, Monica Mallavarapu, Boning Gao, Jihan K. Osborne
Summary: Cell motility is important in various physiological processes, including tumor metastasis and wound healing. Research on human cells has shown that normal cells migrate faster than cancer cells, suggesting potential targets for future therapies.
Article
Multidisciplinary Sciences
Raphael Trefzer, Orly Elpeleg, Tatyana Gabrusskaya, Polina Stepensky, Hagar Mor-Shaked, Robert Grosse, Dominique T. Brandt
Summary: The study reports a non-inherited FMNL2 mutation that affects cellular actin dynamics in immune cells and fibroblasts.
Article
Biochemistry & Molecular Biology
Jovane Hamelin-Morrissette, Angham Dallagi, Julie Girouard, Marion Ravelojaona, Yassine Oufqir, Cathy Vaillancourt, Celine Van Themsche, Christian Carrier, Carlos Reyes-Moreno
MOLECULAR IMMUNOLOGY
(2020)
Retraction
Biochemistry & Molecular Biology
Padma Murthi, Cathy Vaillancourt
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Rona Karahoda, Morgane Robles, Julia Marushka, Jaroslav Stranik, Cilia Abad, Hana Horackova, Jurjen Duintjer Tebbens, Cathy Vaillancourt, Marian Kacerovsky, Frantisek Staud
Summary: The study reveals significant changes in placental tryptophan metabolism associated with preterm birth, suggesting a possible link between abnormal tryptophan metabolism and preterm delivery, with intra-amniotic and maternal inflammatory markers potentially influencing the pathways of tryptophan catabolism.
HUMAN MOLECULAR GENETICS
(2021)
Article
Endocrinology & Metabolism
Fanny Thebault-Dagher, Morgane Robles, Catherine M. Herba, Joey St-Pierre, Celia Brochen, Gina Muckle, Sonia J. Lupien, Jean R. Seguin, William D. Fraser, Cathy Vaillancourt, Sarah Lippe
Summary: Maternal prenatal stress has been associated with earlier febrile seizure onset in children. This study found that placental markers of maternal prenatal stress are linked to febrile seizure incidence and age at first occurrence. Children with febrile seizures showed different placental gene expressions compared to controls, indicating potential candidate mechanisms leading to increased vulnerability in offspring.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Abdelmoumene Benabid, Lara Deslauriers, Isabelle Sinclair, Myriane St-Pierre, Cathy Vaillancourt, Sonia Gagnon, Kelsey N. Dancause
Summary: The study found a curvilinear relationship between sedentary behavior at 16-18 weeks of pregnancy and birthweight, while no linear relationships were observed at other evaluation periods. Both low and high levels of sedentary behavior predicted lower birthweight, and this relationship was independent of physical activity levels.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Cell Biology
Lucas Sagrillo-Fagundes, Thais Casagrande Paim, Luiza Pretto, Isadora Bertaco, Carla Zanatelli, Cathy Vaillancourt, Marcia R. Wink
Summary: Purinergic signaling plays a crucial role in regulating nutrient exchange, immune control, and hormonal exchange between embryo and mother during pregnancy. The modulation of ATP and adenosine on the embryo-maternal interface depends on maternal health status and is increasingly recognized for its role in modulating suboptimal pregnancy conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Fabien Joao, Guillaume Ricaud, Julie Lamoureux, Marjorie Disdier, Veronique Blais, Cecile Adam, Senem Ates, Cheng Wei Xiao, Cyntia Duval, Cathy Vaillancourt, Jacques Bernier, Moncef Benkhalifa, Pierre Miron
Summary: This study evaluated the effect of intrauterine administration of activated peripheral blood mononuclear cells (PBMC) on intrauterine insemination (IUI) success rates. The results showed that there were no significant differences in pregnancy rates and live birth rates between the PBMC group and the control group. Additionally, higher levels of T helper 2, Th22, and T regulatory cells were observed in the activated PBMC compared to baseline.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2022)
Article
Environmental Sciences
Isabelle Plante, Louise M. Winn, Cathy Vaillancourt, Petya Grigorova, Lise Parent
Summary: Pregnancy involves significant physiological and psychological changes in the mother to meet the needs of the growing fetus, with potential long-term impacts on health for both mother and baby. Dysregulation of placental function may lead to increased risk of chronic diseases for the fetus later in life.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Industrial
Marie Laberge, Martin Chadoin, Marion Inigo, Karen Messing, Melanie Lefrancois, Helene Sultan-Taieb, Celine Chatigny, Jessica Riel, Jena Webb, Myriam Fillion, Cathy Vaillancourt, Marie Bellemare
Summary: This article examines the integration of sex and gender by ergonomics students during their internships. The findings suggest that they only minimally considered sex and gender issues in their interventions. The article discusses the barriers to this integration and suggests ways for ergonomists to consider sex and gender in their practice.
Article
Reproductive Biology
Prabu Karthick Parameshwar, Lucas Sagrillo-Fagundes, Nathalia Azevedo Portilho, William A. Pastor, Cathy Vaillancourt, Christopher Moraes
Summary: Recent increases in drug use and exposure to environmental contaminants during pregnancy highlight the importance of placental toxicology. Current in vitro models fail to capture the complexity of placental response, but tissue engineering holds promise in addressing this challenge. This review focuses on using decellularized extracellular matrix in modified forms to recreate aspects of the microenvironment for placental toxicology studies.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Edgar Ontsouka, Mariana Schroeder, Linda Ok, Cathy Vaillancourt, Deborah Stroka, Christiane Albrecht
Summary: By screening the mRNAs coding for enzymes involved in hepatic bile acid synthesis in human and mouse placentas, researchers found that certain genes were species-specifically expressed. CYP7A1, CYP46A1, and BAAT mRNAs were lacking in human placentas but detected in mouse placentas, while Cyp8b1 and Hsd17b1 mRNAs were found in human placentas but not in mouse placentas. CYP39A1/Cyp39a1 and CH25H/Ch25h mRNAs were detected in placentas of both species. The study suggests that placental synthesis of bile acids may play a role in fetoplacental growth and adaptation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Melanie Lefrancois, Helene Sultan-Taieb, Jena Webb, Mathieu-Joel Gervais, Karen Messing, Vanessa Blanchette-Luong, Jessica Riel, Johanne Saint-Charles, Rachel Faust, Cathy Vaillancourt, Myriam Fillion, Marie Laberge
Summary: This scoping review provides a typology of existing guidelines for researchers on how to consider sex/gender in the context of participatory research aimed at improving health, with a focus on occupational and environmental health. The review found that while many sources provide recommendations on incorporating sex/gender during data collection and analysis or during the dissemination of findings, there is a lack of guidance on building partnerships with stakeholders and generating sustainable sex/gender sociopolitical transformations. The review also highlights the specific obstacles and power relationships in occupational health research that require further attention.
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2023)
Article
Materials Science, Biomaterials
Prabu Karthick Parameshwar, Lucas Sagrillo-Fagundes, Caroline Fournier, Sylvie Girard, Cathy Vaillancourt, Christopher Moraes
Summary: This study reveals the impact of changes in ECM composition in preeclampsia on placental trophoblast function, highlighting the important role of disease-specific matrix compositions in trophoblast fusion and suggesting novel matrix-targeting therapeutic strategies for pregnancy-related disorders. The decellularization-based approach used in this research demonstrates the utility of understanding the functional contributions of matrix composition in driving cellular disease phenotypes.
BIOMATERIALS SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Isabelle Sinclair, Myriane St-Pierre, Cathy Vaillancourt, Sonia Gagnon, Kelsey N. Dancause
MATERNAL AND CHILD HEALTH JOURNAL
(2020)
Article
Health Policy & Services
Amede Gogovor, Tatyana Mollayeva, Nicole Etherington, Angela Colantonio, France Legare
HEALTH RESEARCH POLICY AND SYSTEMS
(2020)
