Article
Fisheries
Yang Chen, Ya Chen, Xiaolong Yan, Qi Li, Pengfei Wang, Yuena Sun, Tianjun Xu
Summary: This study reveals that hnRNPub inhibits the NF-kappa B signaling pathway by targeting TRAF6, thereby limiting LPS-induced innate activation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Virology
Zhili Qu, Yuqin Sun, Xuefeng Zhou, Xiaolong Yan, Tianjun Xu
Summary: This study found that overexpression of Smyd3 facilitates the replication of Siniperca chuatsi rhabdovirus (SCRV) and promotes the degradation of TAK1 protein, thus exerting a negative regulatory effect on the NF-kappa B and IRF3 signaling pathways.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Xiaolong Yan, Xueyan Zhao, Ming Zhou, Yuena Sun, Tianjun Xu
Summary: IRF4b and IRF8 negatively regulate the MITA-mediated NF-kappa B signaling pathway in fish by downregulating MITA expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhu Guangwei, Cheng Zhibin, Wang Qin, Lin Chunlin, Lin Penghang, He Ruofan, Chen Hui, Robert M. Hoffman, Ye Jianxin
Summary: TRAF6 affects lymphangiogenesis and promotes colorectal cancer metastasis by influencing ubiquitination of the LPS-NF-kappa B-VEGF-C signaling pathway. TRAF6 124mut is an important ubiquitination site for its interaction with K63-linked chains.
Review
Cell Biology
Tong Zhang, Jianxuan Sun, Jiali Cheng, Wei Yin, Jingwen Li, Heather Miller, Andres A. Herrada, Heng Gu, Hongmei Song, Yan Chen, Quan Gong, Chaohong Liu
Summary: Ubiquitinases are crucial enzymes that modify target proteins through ubiquitination, playing important roles in regulating protein degradation, localization, and function. B lymphocytes differentiate into plasma cells to produce antibodies, participating in humoral immune functions, with ubiquitination playing important roles in B lymphocyte development and function.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Panpan Hou, Penghui Jia, Kongxiang Yang, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu, Deyin Guo
Summary: The study demonstrates that ASB1 positively regulates inflammatory responses by stabilizing TAB2, leading to protection against septic shock and colitis in mice. This finding sheds light on immune regulation in pathogen infection and inflammatory disorders with therapeutic implications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Xiangqin Kuang, Zhuojun Zhang, Difeng Li, Wenhao Bao, Jinyuan Pan, Ping Zhou, Han Chen, Zhiqing Gao, Xiaoyi Xie, Chunxiao Yang, Ge Zhu, Zhongqiu Zhou, Ruiming Tang, Zhengfu Feng, Lihuan Zhou, Xiaoli Feng, Lan Wang, Jianan Yang, Lili Jiang
Summary: In bladder cancer, the downregulation of PI16 is associated with disease progression and poor survival. PI16 inhibits tumor growth and metastasis by suppressing the activation of the NF-kappa B pathway through its interaction with ANXA1. These findings suggest that PI16 may serve as both a tumor suppressor and a potential biomarker for metastatic bladder cancer.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Oncology
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li
Summary: In this study, it was found that overexpression of TRIM47 is associated with tumor progression and poor prognosis in triple-negative breast cancer. The researchers demonstrated that TRIM47 directly interacts with BRCA1 and induces proteasome turnover of BRCA1, leading to a decrease in BRCA1 protein levels in TNBC. Additionally, TRIM47 overexpression confers sensitivity to the PARP inhibitor olaparib, while TRIM47 inhibition confers resistance to olaparib in TNBC. Overexpression of BRCA1 also increases resistance to olaparib in TRIM47-overexpression-induced PARP inhibition sensitivity. These findings suggest that targeting the TRIM47/BRCA1 axis may be a promising prognostic factor and therapeutic target for TNBC.
Review
Cell Biology
Jack Li, Sijin Liu, Shitao Li
Summary: Linear ubiquitination is an important protein modification that attaches a head-to-tail polyubiquitin chain to a substrate protein to mediate signaling pathways. It plays a critical role in various types of cancers, and dysregulation of linear ubiquitination may contribute to tumorigenesis and cancer development.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ayaz Najafov, Hoang Son Luu, Adnan K. Mookhtiar, Lauren Mifflin, Hong-guang Xia, Palak P. Amin, Alban Ordureau, Huibing Wang, Junying Yuan
Summary: RIPK1 is found to promote mTORC1 inhibition during energetic stress, mediating the crosstalk between pro-survival and pro-death pathways. Loss of RIPK1 results in high basal mTORC1 activity, defective lysosomes, and susceptibility to low energy levels. Inhibiting mTORC1 rescues lysosomal defects and vulnerability to energetic stress, prolonging survival in RIPK1-deficient neonatal mice.
Article
Biochemistry & Molecular Biology
Valentine Spagnol, Caio A. B. Oliveira, Suzanne J. Randle, Patricia M. S. Passos, Camila R. S. T. B. Correia, Natalia B. Simaroli, Joice S. Oliveira, Tycho E. T. Mevissen, Ana Carla Medeiros, Marcelo D. Gomes, David Komander, Heike Laman, Felipe Roberti Teixeira
Summary: The study reveals that Fbxo7 interacts with UXT-V2, leading to its ubiquitination and subsequent proteasomal degradation, ultimately inhibiting the NF-kappa B signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Cell Biology
Shuang Shang, Yu-wei Yang, Fei Chen, Liang Yu, Shuo-hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-jiao Yu, Xiao-wei Zhang, Ping-ping Li, Sheng-tao Zhu, Hai-zeng Zhang, Fang Hua
Summary: TRIB3 inhibits CD8(+) T cell infiltration in colorectal cancer by inhibiting STAT1 activation and reducing tumor-infiltrating T cells. Acetyltransferase P300 acetylates TRIB3 and prevents its ubiquitination and degradation. Genetic ablation of TRIB3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor increases T cell recruitment and sensitizes colorectal cancers to immune checkpoint blockade therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Environmental Sciences
Jie Gu, Zhen Ren, Jinfeng Zhao, Frank Addai Peprah, Yimin Xie, Dongrui Cheng, Yanwei Wang, Haitao Liu, Chris Kong Chu Wong, Yang Zhou, Haifeng Shi
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Review
Medicine, Research & Experimental
Anthony A. Kosiba, Yanwei Wang, Dongfeng Chen, Chris Kong Chu Wong, Jie Gu, Haifeng Shi
Article
Oncology
Dandan Wu, Shudong Hu, Yongzhong Hou, Yingying He, Shubai Liu
Article
Biochemistry & Molecular Biology
Qian Gou, Yidan Jiang, Runyun Zhang, Ying Xu, Huihui Xu, Wenbo Zhang, Juanjuan Shi, Yongzhong Hou
Article
Biochemistry & Molecular Biology
Xi Sun, Yanwei Wang, Tingya Jiang, Xiao Yuan, Zhen Ren, Alex Tuffour, Haitao Liu, Yang Zhou, Jie Gu, Haifeng Shi
Summary: This study investigated the proteomic profile changes induced by cadmium in the kidney using a mouse model. It was found that cadmium regulates kidney metabolism, promotes renal damage and cell migration. The downregulation of Na(+)/H(+) exchange regulatory cofactor (NHERF3) could contribute to renal damage, along with a decrease in transferrin (TRF) in the kidney.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Cell Biology
Yalan Duan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi, Yongzhong Hou
Summary: Autophagy is a catabolic process that degrades intracellular components in lysosomes, potentially affecting cancer cell immune evasion. It may induce degradation of immune checkpoint proteins and manipulate antigen presentation and T cell activity in immune cells. These contradictory effects may stem from different experimental contexts or models.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Jiajun Ding, Qian Gou, Xiao Jia, Qian Liu, Jianhua Jin, Juanjuan Shi, Yongzhong Hou
Summary: The study found that AMPK-induced PPARδ-S50 phosphorylation, accumulation of misfolded PPARδ protein, and inhibition of PPARδ transcription activity can suppress colon tumor formation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Cell Biology
Deting Gong, Mingjun Chen, Yuhan Wang, Juanjuan Shi, Yongzhong Hou
Summary: Ferroptosis, triggered by intracellular iron, leads to cell death through the accumulation of lipid peroxidation. Cancer cells can evade ferroptosis by activating antioxidant signaling pathways. Besides transcriptional regulation, ferroptosis can also be modulated by ubiquitination or autophagic degradation. Induction of ferroptosis enhances immune cell activity, but it may impair T cell activity as well. Therefore, rational combined therapy is crucial for cancer treatment.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Yuyang Dai, Jinsong Liu, Xuyan Li, Jianzhong Deng, Cheng Zeng, Wenbin Lu, Yongzhong Hou, Ying Sheng, Honglin Wu, Qian Liu
Summary: This research aims to investigate the regulatory network of NKD1 and miRNAs in colon cancer. The study identified let-7b-5p as a miRNA that can inhibit colon cancer cell proliferation, migration, and invasion by targeting NKD1. Further analysis revealed that NKD1 enhances colon cancer cell proliferation and migration by inhibiting APC expression.
Article
Chemistry, Multidisciplinary
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou
Summary: Immune cells play a role in protecting against tumor progression, while aberrant expression of PD-L1 in cancer cells leads to tumor immune escape. This study found that ING4 induces the autophagic degradation of PD-L1, inhibiting immune escape in NSCLC. However, high expression of CK2 was found to correlate with low ING4 protein levels in NSCLC. Further analysis revealed that CK2 induces the phosphorylation of ING4-S150, leading to its degradation by JFK ubiquitin ligase. In contrast, CK2 gene knockout increased ING4 protein stability and T cell activity, inhibiting NSCLC immune escape. Additionally, the combination of a CK2 inhibitor and PD-1 antibody effectively enhanced antitumor immunotherapy.
Review
Biochemistry & Molecular Biology
Xiao Jia, Bingjun Yan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi, Yongzhong Hou
Summary: Immune evasion of cancer cells is mediated by the SIRPα-CD47 axis, but blocking the CD47-SIRPα interaction can enhance phagocytic clearance of cancer cells, activate immune responses, promote antigen presentation, and ultimately activate antitumor immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Qian Gou, Chen Dong, Huihui Xu, Bibimaryam Khan, Jianhua Jin, Qian Liu, Juanjuan Shi, Yongzhong Hou
CELL DEATH & DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Qian Liu, Jianzhong Deng, Chunxia Yang, Yue Wang, Ying Shen, Hua Zhang, Zhixiang Ding, Cheng Zeng, Yongzhong Hou, Wenbin Lu, Jianhua Jin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Li Gao, Huixing Wang, Zebin Deng, Wenwen Xiang, Haifeng Shi, Bing Xie, Haixia Shi
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Materials Science, Multidisciplinary
Li Xu, Hailong Wang, Zihan Chu, Lawrence Cai, Haifeng Shi, Chunyin Zhu, Donghui Pan, Jia Pan, Xiang Fei, Yabin Lei
ACS APPLIED POLYMER MATERIALS
(2020)
