期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 11, 期 3, 页码 294-304出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2013.70
关键词
core antigen; hepatitis C virus; monocytes; PD-L1/CD86; viral load
类别
资金
- National Natural Science of China [81271826, 31100126]
- National Science Foundation of Beijing [7122108]
- SKLID development grant [2011SKLID207]
- National S&T Major Project for Infectious Diseases [2012ZX10002003, 2012ZX10002005]
Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14(+/dim)CD16(+)-in chronic HCV-infected patients, HCV spontaneous resolvers and healthy controls, and we evaluated the possible link between HCV viremia and disease progression. Our results indicated that the frequency of the CD14(++)CD16(+) monocyte subset was decreased, and negatively correlated with HCV RNA and core antigen levels during chronic HCV infection. PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic HCV infection than in spontaneous HCV resolvers and healthy controls. The PD-L1/CD86 ratio positively correlated with HCV viral load and core antigen levels. Finally, PD-L1 was significantly increased, while cytokine secretions were dramatically decreased upon Toll-like receptor (TLR) ligand binding and HCV JFH-1stimulation. These findings indicates the compromised immune status of the CD14(++)CD16(+) monocytes during chronic HCV infection and provides new insights into the specific role of the CD14(++)CD16(+) monocytes and their significance in chronic HCV infection.
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