期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 12, 期 6, 页码 692-699出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cmi.2014.108
关键词
macrophage polarization; monocyte; response gene to complement 32
类别
资金
- National Nature Science Foundation of China [31270971, 81072406, 31100650]
- China Postdoctoral Science Foundation [2013M541922]
- Independent Innovation Foundation of Shandong University [2012TS143]
Response gene to complement 32 (RGC-32) is a cell cycle regulator involved in the proliferation, differentiation and migration of cells and has also been implicated in angiogenesis. Here we show that RGC-32 expression in macrophages is induced by IL-4 and reduced by LPS, indicating a link between RGC-32 expression and M2 polarization. We demonstrated that the increased expression of RGC-32 is characteristic of alternatively activated macrophages, in which this protein suppresses the production of pro-inflammatory cytokine IL-6 and promotes the production of the anti-inflammatory mediator TGF-beta. Consistent with in vitro data, tumor-associated macrophages (TAMs) express high levels of RGC-32, and this expression is induced by tumor-derived ascitic fluid in an M-CSF-and/or IL-4-dependent manner. Collectively, these results establish RGC-32 as a marker for M2 macrophage polarization and indicate that this protein is a potential target for cancer immunotherapy, targeting tumor-associated macrophages.
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