Review
Medicine, General & Internal
Peng Liu, Jing Zhang, Yun Wang, Zhengri Shen, Chen Wang, Dan-Qian Chen, Xinping Qiu
Summary: Tripterygium wilfordii Hook. f. (TWHF) and its active compounds, such as tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol, have been found to exhibit effects in attenuating diabetic nephropathy through anti-inflammation, anti-oxidative stress, anti-fibrosis, and other mechanisms.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, Research & Experimental
Jing Song, Guan-Nan He, Long Dai
Summary: This review summarizes the three main active ingredients of Tripterygium wilfordii Hook F (TWHF): celastrol, triptolide, and triptonide. These compounds have shown significant pharmacological activity and therapeutic effects in cancer, obesity, and diabetes. However, their toxicity limits their clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Wu Gang, Hu Hao, Huang Yong, Feng Ruibing, Li Chaowen, Huang Yizheng, Li Chao, Zhang Haitao
Summary: This review emphasizes the therapeutic potential of Triptolide, a compound extracted from the Chinese medicinal herb Tripterygium wilfordii Hook F, in treating bone-related disorders, including inflammatory and cancerous bone tumors. The extracts of Tripterygium wilfordii Hook F have been used for centuries as anti-inflammatory, antiproliferative, antioxidative, and immunosuppressive agents, and continuous research and modifications have been made to enhance their utility in various diseases and pathophysiology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yijun Luo, Xiaoxiao Hou, Anran Xi, Mengxian Luo, Keer Wang, Zhenghao Xu
Summary: This study evaluated the efficacy and safety of the combination therapy of Tripterygium wilfordii Hook F (TwHF) and Methotrexate (MTX) for rheumatoid arthritis (RA) through a meta-analysis of randomized clinical trials (RCTs). The results showed that TwHF + MTX had higher effectiveness and remission rates compared to MTX monotherapy, and it also improved clinical symptoms and laboratory indexes. The addition of TwHF did not increase the risk of adverse events, and even reduced the risk of infection and liver-related adverse events.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hui-lin Zeng, Qian Qiu, Ting-xiong Fu, Ai-ping Deng, Xiang-yang Xie
Summary: The study aimed to develop, formulate, and optimize sustained release triptolide microspheres using poly (lactide-co-glycolide) (PLGA) for the treatment of rheumatoid arthritis. The prepared microspheres exhibited sustained release of triptolide in vitro and had high drug encapsulation efficiency and good microsphere characteristics.
Article
Plant Sciences
Yijia Xu, Wenwen Li, Ruojin Wen, Jianfang Sun, Xin Liu, Shangfeng Zhao, Jinghai Zhang, Yanfeng Liu, Mingyi Zhao
Summary: The study aimed to identify the mechanisms responsible for the pharmacological activity and cardiotoxicity of the main monomers of Tripterygium wilfordii. It was found that the monomers could bind to ion channels and inhibit their currents, exhibit analgesic effects on formalin-induced pain, and one monomer showed potential cardiac risk. These findings provide an important theoretical basis for the further screening of active monomers with higher levels of activity and lower levels of toxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xue Tong, Yanheng Qiao, Yuanjian Yang, Haizhao Liu, Zhiyong Cao, Bo Yang, Lijuan Wei, Hongtao Yang
Summary: This article introduces the main preparations of Tripterygium wilfordii Hook.f. (TwHF) in the Chinese market and their characteristics, as well as summarizes the clinical applications and influential mechanisms of TwHF and its preparations in kidney diseases. The application of TwHF in kidney diseases may be more complicated due to the close relationship between nephropathy and immune inflammation, and this study aims to reveal its role and mechanisms, providing more insights for nephropathy research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Zhichao Yu, Zhe Feng, Ling Fu, Jing Wang, Changqing Li, Huaxu Zhu, Tong Xie, Jie Zhou, Lingling Zhou, Xueping Zhou
Summary: This study found that Tripterygium wilfordii can cause liver injury by interfering with lipid metabolism, and Qingluotongbi can protect against this toxic effect. Tripterygium wilfordii upregulates LXR alpha to activate endoplasmic reticulum stress (ERS) and increase lipid synthesis, while Qingluotongbi inhibits the LXR alpha-ERS-SREBP-1c pathway to reduce abnormal lipid synthesis and liver toxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Linluo Zhang, Jie Zhou, Zhe Feng, Baoping Jiang, Changqing Li, Lingling Zhou, Xueping Zhou
Summary: This study aimed to explore the important roles of mitophagy and endoplasmic reticulum stress (ERS) and the relationship between them in Qingluo Tongbi Formula (QTF) in alleviating Tripterygium wilfordii Hook. F. (TW)-induced hepatotoxicity. The results showed that QTF reduced excessive mitophagy and ERS in TW-induced hepatotoxicity and different components of QTF played differential roles in downregulating the PERK-ATF4 pathway and mitigating mitophagy and ERS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yadan Wang, Jiangong Yan, Zhongmou Zhang, Minghui Chen, Xianfu Wu, Shuangcheng Ma
Summary: In this study, ten new sesquiterpene pyridine alkaloids (SPAs) were isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine used to treat autoimmune diseases. Four of these compounds were found to exhibit potent immunosuppressive activity, indicating the potential of T. wilfordii as an immunomodulatory agent.
Article
Chemistry, Analytical
Shu Chen, Li Liu, Hong-Xia Jiang, Qun Sun, Liang Zhang, Jian-Qun Liu, Li-Fang Liu
Summary: In vitro studies have shown that roasting Tripterygium wilfordii (TW) can effectively reduce its toxicity and detoxify it by reducing the content of celastrol and total alkaloids, which are the main toxic components.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Plant Sciences
Di Jin, Miao Yu, Xiangyan Li, Xiuge Wang
Summary: The study evaluated the efficacy of Tripterygium wilfordii (TwHF) in treating diabetic nephropathy through a systematic review and meta-analysis of animal models, finding that TwHF can improve kidney pathology, renal function indicators, and blood sugar levels. TwHF is effective and safe for treating Diabetic Kidney Diseases by protecting the kidneys through anti-inflammation and other mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Song Zhang, Baihan Chen, Dawei Liu, Hongxiang Chen
Summary: This study developed a low-cost, highly active low-temperature plasma jet array, which significantly improved the severe psoriasiform dermatitis by enhancing the transdermal delivery of the medicine without noticeable side effects. It provides a potential new solution for psoriasis treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Plant Sciences
Xiaosheng Liu, Ling Lin, Tingxia Lv, Lianfeng Lu, Xiaodi Li, Yang Han, Zhifeng Qiu, Xiaoxia Li, Yanling Li, Xiaojing Song, Wei Cao, Taisheng Li
Summary: This study systematically verified the mechanisms of TwHF in treating INRs, revealing that TwHF treats INRs by inhibiting the IFN signaling pathway and STAT1. The results provide a basis for further application of TwHF analogs in treating INRs.
Article
Immunology
Xuan Zhang, Huaxia Yang, Xiaoxia Zuo, Lijun Wu, Jiangyun Peng, Zhenbin Li, Hongbin Li, Wei Ji, Liyun Zhang, Xiaomei Li, Lie Dai, Liangjing Lu, Niansheng Yang, Wei Wei, Zongwen Shuai, Ying Jiang, Yudong Liu, Peter E. Lipsky, Hua Chen
Summary: This investigator-initiated, multicentre, randomized, double-blind, triple-dummy, controlled trial conducted in China evaluated the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with recombinant human TNF receptor IgGFc fusion protein (rhTNFR-Fc) in treating active Rheumatoid Arthritis (RA). The results showed that TwHF+rhTNFR-Fc was superior to MTX for active RA and more effective than MTX + rhTNFR-Fc in achieving ACR50, with a similar safety profile.
CLINICAL IMMUNOLOGY
(2023)