期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 8, 期 3, 页码 213-225出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2010.77
关键词
antimicrobial peptides; autoimmune disease; immune reconstitution inflammatory syndrome; immunopathology; innate immunity; metagenomics
类别
Microbes are increasingly being implicated in autoimmune disease. This calls for a re-evaluation of how these chronic inflammatory illnesses are routinely treated. The standard of care for autoimmune disease remains the use of medications that slow the immune response, while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune response. Immunostimulation is complicated by a cascade of sequelae, including exacerbated inflammation, which occurs in response to microbial death. Over the past 8 years, we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory disease. This intervention, designed to stimulate the innate immune response, has required a reevaluation of disease progression and amelioration. Paramount is the inherent conflict between palliation and microbicidal efficacy. Increased microbicidal activity was experienced as immunopathology-a temporary worsening of symptoms. Further studies are needed, but they will require careful planning to manage this immunopathology. Cellular & Molecular Immunology (2011) 8, 213-225; doi:10.1038/cmi.2010.77; published online 31 January 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据