Review
Cell Biology
Yao Song, Liu Wang, Lan Zhang, Dingming Huang
Summary: Semaphorins are a group of highly conserved proteins that play a role in axon guidance during neurogenesis and have physiological functions in various organ systems. SEMA7A, an immune semaphorin, regulates diverse immunoinflammatory processes and tumor progression by interacting with specific receptors PLXNC1 and integrins. This review focuses on the role of SEMA7A in autoimmune disorders, inflammatory diseases, and tumors, as well as potential strategies for targeting SEMA7A as a predictive, diagnostic, and therapeutic agent for these conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Emanuela Senjor, Janko Kos, Milica Perisic Nanut
Summary: Cysteine cathepsins, the most abundant proteases in lysosomes, play essential roles in various cellular processes. Their upregulation is associated with pathological conditions such as cancer and neurodegeneration. This review provides an overview of their involvement in immune disorders and suggests potential targeting options.
Article
Immunology
He Li, Yuehan Gao, Lihui Xie, Rong Wang, Runping Duan, Zhaohuai Li, Binyao Chen, Lei Zhu, Xianggui Wang, Wenru Su
Summary: Single-cell transcriptional immune cell atlas based on prednisone-treated or untreated experimental autoimmune uveitis (EAU) mice revealed that prednisone partially reversed the globally activated immune cells in terms of cell composition, gene expression, transcription factor regulation, and cell-cell communication, with significant rescue effects on T and B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Mineto Ota, Masahiro Nakano, Yasuo Nagafuchi, Satomi Kobayashi, Hiroaki Hatano, Ryochi Yoshida, Yuko Akutsu, Takahiro Itamiya, Nobuhiro Ban, Yumi Tsuchida, Hirofumi Shoda, Kazuhiko Yamamoto, Kazuyoshi Ishigaki, Tomohisa Okamura, Keishi Fujio
Summary: This study constructed a large-scale repertoire catalogue of five B cell subsets of patients with immune-mediated diseases (IMDs) and investigated their biological mechanisms. The results showed that autoimmune diseases were associated with a shortened CDR-H3 length in naive B cells and a negative correlation between interferon signature strength and CDR-H3 length, suggesting the role of interferon in premature B cell development. The study also found gene usage skewing in plasmablasts and unswitched-memory B cells of patients with systemic lupus erythematosus (SLE), and this skewing was ameliorated after belimumab treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Liam P. Devenish, Musa M. Mhlanga, Yutaka Negishi
Summary: Mammalian immune cells need to respond rapidly and effectively to different challenges to combat pathogens, with cellular heterogeneity and changes in genome structures playing crucial roles in regulating immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amit Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Summary: Tertiary lymphoid organs (TLOs) are immune cell collections that form in non-lymphoid tissues in response to local chronic inflammation. They have complex structures and can generate strong immune responses at sites of tissue injury. Despite our improved understanding of TLO formation and function, their role in chronic inflammatory diseases remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Zehui Lei, Jing Wang, Lingqiang Zhang, Cui Hua Liu
Summary: Membrane trafficking relies on the regulation of small GTPases, which can be modulated through post-translational modifications such as ubiquitination. Dysregulation of small GTPase ubiquitination may lead to various human diseases, highlighting the importance of understanding the molecular mechanisms involved.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: HLA-G, a non-classical MHC class I molecule, has been studied for its relevance in pathological conditions like autoimmune diseases. Current research aims to utilize HLA-G in clinical practice for diagnostics and therapeutic purposes, as it is known for its immunomodulatory role in reducing inflammation and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Guojiao Lin, Jialiang Wang, Yong-Guang Yang, Yuning Zhang, Tianmeng Sun
Summary: This paper reviews the research progress on how nano-delivery systems can be modulated for targeted delivery to dendritic cells and induce immune tolerance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Rheumatology
Zachary S. Wallace, Gandarvaka Miles, Ekaterina Smolkina, Natalia Petruski-Ivleva, Duane Madziva, Claire Cook, Xiaoqing Fu, Yuqing Zhang, John H. Stone, Hyon K. Choi
Summary: This study describes the epidemiology of IgG4-related disease (IgG4-RD) in the USA, finding that the incidence and prevalence of IgG4-RD are increasing, and patients with IgG4-RD have a higher risk of death.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Cell Biology
Sayan Chakraborty, Poulomi Khamaru, Arindam Bhattacharyya
Summary: Metabolism plays a crucial role in balancing the energy, molecular biosynthesis, and effector activity requirements of different immune cells. Understanding and targeting the metabolic pathways of immune cells in health and disease can lead to potent therapeutic measures to restore their functionality.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Iago Pinal-Fernandez, Angela Quintana, Jose Cesar Milisenda, Maria Casal-Dominguez, Sandra Munoz-Braceras, Assia Derfoul, Jiram Torres-Ruiz, Katherine Pak, Stefania Dell'Orso, Faiza Naz, Gustavo Gutierrez-Cruz, Margherita Milone, Shahar Shelly, Yaiza Duque-Jaimez, Ester Tobias-Baraja, Ana Matas-Garcia, Gloria Garrabou, Joan Padrosa, Javier Ros, Ernesto Trallero-Araguas, Brian Walitt, Lisa Christopher-Stine, Thomas E. Lloyd, Chen Zhao, Shannon Swift, Arun Rajan, Josep Maria Grau-Junyent, Albert Selva-O'Callaghan, Teerin Liewluck, Andrew Lee Mammen
Summary: This study identified three distinct types of immune checkpoint inhibitor-associated myositis (ICI-myositis) based on gene expression patterns, including ICI-DM, ICI-MYO1 and ICI-MYO2. ICI-DM patients overexpressed type 1 interferon-inducible genes, similar to dermatomyositis (DM) patients. ICI-MYO1 patients had highly inflammatory muscle biopsies and developed coexisting myocarditis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Yingzi Zhu, Heng Gu, Lu Yang, Na Li, Qiuyue Chen, Danqing Kang, Shengyan Lin, Yukai Jing, Panpan Jiang, Qianglin Chen, Li Luo, Ju Liu, Jiang Chang, Zhenzhen Li, Yi Wang, Xin Dai, Heather Miller, Lisa S. Westerberg, Chan-Sik Park, Masato Kubo, Quan Gong, Lingli Dong, Chaohong Liu
Summary: CCR2 regulates BCR signaling through the MST1/mTORC1/STAT1 axis. The deficiency of CCR2 reduces the proportion and number of follicular B cells, enhances BCR proximal signaling, and promotes oxidative phosphorylation of B cells. CCR2 deficiency also induces actin filament aggregation and early-activation events of B cells. Glomerular IgG deposition is observed in CCR2-deficient mice, and the expression of CCR2 is decreased in peripheral B cells of SLE patients.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Jinhua He, Jian Shen, Wenfeng Luo, Zeping Han, Fangmei Xie, Ting Pang, Liyin Liao, Zhonghui Guo, Jianhao Li, Yuguang Li, Hanwei Chen
Summary: Single-cell omics is a method of analyzing individual cells through sequencing and other technologies, providing new perspectives and methods for studying cellular behavior and mechanisms. It overcomes the problem of cellular heterogeneity and plays a significant role in basic research and precision medicine.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Junjie Gu, Chongying Su, Fei Huang, Yuwei Zhao, Jing Li
Summary: This article discusses the roles of circRNAs in immune-related diseases, including their expression profile analysis, potential biomarker research, impact on phenotypes, and applications and prospects in therapeutic target seeking.
FRONTIERS IN IMMUNOLOGY
(2022)
