期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 8, 期 1, 页码 75-82出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2010.37
关键词
ADV; cytokine; ETV; HBV; Treg
类别
资金
- Eleventh Five-Year Plan for AIDS and viral hepatitis, prevention and treatment of infectious diseases and other major science and technology [2008ZX10002-004]
- Ministry of Health Clinical Disciplines [20073531]
- National Natural Science Foundation of China [30771912, 30972610, 30972611]
- Jilin Province Science and Technology Agency [200705128]
- BMS
Chronicity of hepatitis B (CHB) infection is characterized by a weak immune response to the virus. Entecavir (ETV) and adefovir dipivoxil (ADV) are effective in suppressing hepatitis B virus (HBV) replication. However, the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood. In this study, regulatory T cells (Tregs) and intracellular cytokines, including IL-2, interferon (IFN)-gamma, tumor-necrosis factor (TNF)-alpha and IL-4, were measured prior to and at 12, 24, 36 and 48 weeks after treatment with ETV or ADV. The cytokines were increased from 24 to 48 weeks after treatment. Higher levels of Th1 cytokines were observed with ETV (n=29) versus ADV (n=28) treatment. By contrast, the numbers of Tregs in both groups were decreased. The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups, which may contribute to their therapeutic effect in CHB infection. Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. Cellular & Molecular Immunology (2011) 8, 75-82; doi:10.1038/cmi.2010.37; published online 4 October 2010
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