期刊
CELLS TISSUES ORGANS
卷 197, 期 3, 页码 209-223出版社
KARGER
DOI: 10.1159/000343740
关键词
Differentiation potential; Gene expression; Mesenchymal stem cells; Periodontal ligament; Umbilical cord; Wharton's jelly
资金
- National Basic Research Program of China [2010CB944801]
- National Natural Science Foundation of China [81070798, 81170931]
- Funding Project to Science Facility in Institutions of Higher Learning under the jurisdiction of the Beijing Municipality [PXM2011_014226_07_000066]
- Beijing Science and Technology Funding Project for Outstanding Returned Overseas Chinese Scholars
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2012-940]
PDLSC-mediated periodontal tissue regeneration-is considered a promising method for periodontitis treatment, but the supply of PDLSCs is limited. As a potential alternative, WJCMSCs are readily available; however, there is a lack of evidence proving that WJCMSCs are suitable for periodontal tissue regeneration. In this study, we investigated the characteristics of WJCMSCs and PDLSCs. We found the osteo-/dentinogenic, adipogenic and chondrogenic differentiation potentials of PDLSCs were more powerful than those of WJCMSCs. Microarray analysis discovered that 903 genes were significantly down-regulated and 726 genes up-regulated in WJCMSCs compared with PDLSCs. Based on the microarray data, we found that several genes may be associated with MSCs characteristics. Further bioinformatic analysis identified that TGF-beta and WNT signaling pathways, and several genes, including STAT5B and ITGA4, may play key roles in MSCs. Our results indicate that the differentiation potentials of WJCMSCs are far less than those of PDLSCs, and that unmodified WJCMSCs may not be good seeding cells for periodontal tissue regeneration. Our results also help to elucidate the differentiation mechanisms in MSCs and to find the key factors to prompt WJCMSC-mediated periodontal tissue regeneration. Copyright (c) 2012 S. Karger AG, Basel
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