Article
Biochemistry & Molecular Biology
Ioanna E. Stergiou, Konstantinos Kambas, Aikaterini Poulaki, Stavroula Giannouli, Theodora Katsila, Aglaia Dimitrakopoulou, Veroniki Vidali, Vasileios Mouchtouris, Ismini Kloukina, Evangelia Xingi, Stamatis N. Pagakis, Lesley Probert, George P. Patrinos, Konstantinos Ritis, Athanasios G. Tzioufas, Michael Voulgarelis
Summary: Myelodysplastic syndromes (MDS) involve a group of disorders affecting hematopoietic stem and progenitor cells, with a particular focus on the role of the transcription factor HIF-1. Aberrant HIF-1 stabilization and pseudohypoxia are prominent features in MDS pathobiology, showing potential for therapeutic manipulation in benign cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Summary: The study demonstrates that CTSL is a novel target gene of HIF-1 alpha and plays a role in melanosome degradation in melanocytes through lysosomal activity during autophagosome-lysosome fusion. Under autophagy-inducing starvation conditions, the expression of HIF-1 alpha and CTSL is upregulated in melan-a cells. Inhibition of conversion of pro-CTSL to mature CTSL leads to accumulation of certain proteins due to decreased lysosomal activity in the autophagic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Qingzhuang Yang, Lianghui Gao, Xiaolong Huang, Jie Weng, Youke Chen, Shibu Lin, Qiushi Yin
Summary: Sorafenib can inhibit the growth of liver cancer cells by stimulating autophagy and the HIF-1 signaling pathway. Additionally, Sorafenib can prevent the malignant behavior of liver cancer cells by inducing hypoxia and autophagy in HepG2 cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Junmei Li, Lin Qi, Ziyang Diao, Mengyu Zhang, Bin Li, Yunyi Zhai, Mingyue Hao, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang
Summary: Studies have shown that the Brucella effector BtpB manipulates host cell infection by promoting apoptosis and inhibiting autophagy. In addition, the autophagy inhibitor chloroquine can reduce intracellular survival of Brucella.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Jianping Tang, Yanjun Li, Xu Liu, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Yating Zhang, Wenya Shao, Siying Wu, Huangyuan Li
Summary: Cobalt is an environmental toxicant that can damage the nervous system even at low doses. The molecular mechanism behind cobalt-induced neurodegeneration is still not well understood. In this study, we investigated the relationship between cobalt-induced neurodegeneration and autophagy, as well as the involvement of HIF-1 alpha and ROS in this process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Deqiang Fu, Xingyue Liang, Yuxuan Jiang, Jieping Liu, Xiaosi Lin, Quan Yang, Xue Chen, Ping Huang, Wei Wang, Wenlin Wu
Summary: Iron accumulation in the brain has been implicated in the pathogenesis of various neurodegenerative diseases. Autophagy induction has been proposed as a potential therapeutic strategy, but the relationship between autophagy and iron is not well understood. This study found that iron induces autophagosome accumulation and disrupts the autophagic flux in microglia, which may contribute to iron neurotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Larissa Ho Ching Tang, Frederic Khe Cheong Fung, Angela Ka Wai Lai, Ian Yat Hin Wong, Kendrick Co Shih, Amy Cheuk Yin Lo
Summary: The role of macroautophagy in ocular ischemia/reperfusion injuries under hyperglycemia is still unclear. The study investigated the involvement of autophagy in different glycemic states and found that autophagic markers were upregulated after short reperfusion, but decreased after long reperfusion. Autophagic inhibition under hypoxic conditions decreased cell survival and induced structural changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Takeshi Yamamoto, Yoshitsugu Takabatake, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Tomonori Kimura, Isao Matsui, Jun-Ya Kaimori, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka
Summary: The study found that supplementation with EPA can alleviate renal lipotoxicity by reducing phospholipid accumulation in lysosomes, improving mitochondrial dysfunction, reducing inflammation and fibrosis. EPA alleviates renal lipotoxicity by improving lysosomal function and autophagic flux in both high-fat diet-fed mice and isolated PTECs cultured in palmitic acid, indicating its potential as a novel treatment for obesity-related kidney diseases.
Article
Integrative & Complementary Medicine
Lijuan Hu, Xiaoqing Xu, Xijuan Chen, Shuai Qiu, Qiuju Li, Dapeng Zhang, Feng Wang
Summary: In this study, it was investigated whether EGCG can decrease HIF-1α expression in pancreatic cancer cells. The results showed that EGCG reduced both the production and stability of HIF-1α, leading to decreased cell growth and tumor development. This study revealed the mechanism of EGCG inhibition in pancreatic cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Cell Biology
Lars Schlotawa, Ana Lopez, Gentzane Sanchez-Elexpuru, Sylwia D. Tyrkalska, David C. Rubinsztein, Angeleen Fleming
Summary: Much of our understanding of the regulation of macroautophagy/autophagy comes from in vitro studies, and there is still a lack of knowledge about its regulation in different tissues in vivo. Upregulation of autophagy is considered a promising therapeutic strategy, so it is important to understand its function in different tissues through in vivo analysis. To achieve this, an inducible expression system has been developed in zebrafish to up- or downregulate autophagy, allowing the investigation of how cell- or tissue-specific changes in autophagic flux affect processes such as aging, inflammation, and neurodegeneration.
Article
Microbiology
Pengfei Hou, Yidi Guo, Hongli Jin, Jingxuan Sun, Yujie Bai, Wujian Li, Ling Li, Zengguo Cao, Fangfang Wu, Haili Zhang, Yuanyuan Li, Songtao Yang, Xianzhu Xia, Pei Huang, Hualei Wang
Summary: Autophagy can be induced by viral infection and replication, and autophagosomes generated can influence the replication of RABV. Neuron-specific Bif-1 isoforms (Bif-1b/c/e) inhibit RABV replication by preventing autophagosome accumulation and blocking autophagic flux induced by the virus, while ubiquitous Bif-1 isoforms do not have the same effect.
MICROBIOLOGY SPECTRUM
(2023)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Environmental Sciences
Yan Wang, Na Liu, Xiaoquan Huang, Wangcheng Hu, Ying Ma, Ying Liang, Wenjing Xie, Meng Tang
Summary: The study found that exposure to PM SRM1648a increased LC3II expression and autophagosome accumulation in HUVECs, indicating impaired autophagic degradation function. Through experiments and analysis, it was revealed that the detrimental effects of PM SRM1648a on lysosomal function lead to the blockage of autophagic flux, ultimately resulting in endothelial cell damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Oncology
Qi Zhang, Zhenzhen Han, Yanbo Zhu, Jingcheng Chen, Wei Li
Summary: Cancer stem cells (CSCs) play a decisive role in cancer recurrence, metastasis, and resistance to treatment. Hypoxia inducible factor-1 (HIF-1) is an important molecule in regulating CSC development under hypoxic conditions, but the specific mechanism is still unclear.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Adam M. Zahm, Michael A. Bucaro, Portonovo S. Ayyaswamy, Vickram Srinivas, Irving M. Shapiro, Christopher S. Adams, Karthik Mukundakrishnan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2010)
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Microbiology
Constantinos Ketonis, Stephanie Barr, Christopher S. Adams, Irving M. Shapiro, Javad Parvizi, Noreen J. Hickok
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2011)
Article
Rheumatology
Jolene Bohensky, Shawn P. Terkhorn, Theresa A. Freeman, Christopher S. Adams, Joseph A. Garcia, Irving M. Shapiro, Vickram Srinivas
ARTHRITIS AND RHEUMATISM
(2009)
Article
Engineering, Biomedical
Valentin Antoci, Christopher S. Adams, Javad Parvizi, Helen M. Davidson, Russell J. Composto, Theresa A. Freeman, Eric Wickstrom, Paul Ducheyne, Donald Jungkind, Irving M. Shapiro, Noreen J. Hickok
Article
Endocrinology & Metabolism
Adam M. Zahm, Michael A. Bucaro, Vickram Srinivas, Irving M. Shapiro, Christopher S. Adams
Article
Endocrinology & Metabolism
Constantinos Ketonis, Stephanie Barr, Irving M. Shapiro, Javad Parvizi, Christopher S. Adams, Noreen J. Hickok
Article
Orthopedics
Constantinos Ketonis, Javad Parvizi, Christopher S. Adams, Irving M. Shapiro, Noreen J. Hickok
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2009)
Article
Orthopedics
Constantinos Ketonis, Stephanie Barr, Christopher S. Adams, Noreen J. Hickok, Javad Parvizi
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2010)
Article
Engineering, Biomedical
Helen Davidson, Martin Poon, Ray Saunders, Irving M. Shapiro, Noreen J. Hickok, Christopher S. Adams
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2015)
Article
Orthopedics
Christopher S. Adams, Valentin Antoci, Gerald Harrison, Payal Patal, Terry A. Freeman, Irving M. Shapiro, Javad Parvizi, Noreen J. Hickok, Shula Radin, Paul Ducheyne
JOURNAL OF ORTHOPAEDIC RESEARCH
(2009)
Article
Cell & Tissue Engineering
G. K. Toworfe, S. Bhattacharyya, R. J. Composto, C. S. Adams, I. M. Shapiro, P. Ducheyne
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2009)
Article
Genetics & Heredity
James R. Gilbert, Christopher S. Adams, Irving M. Shapiro, Noreen J. Hickok
Article
Cell & Tissue Engineering
Constantinos Ketonis, Christopher S. Adams, Stephanie Barr, Amiethab Aiyer, Irving M. Shapiro, Javad Parvizi, Noreen J. Hickok
TISSUE ENGINEERING PART A
(2010)
Article
Orthopedics
Ray K. Saunders, Joseph Infanti, Hibah Ali, Timothy Shuey, Courtney Potteiger, Shelby McNeilly, Christopher S. Adams
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)