Article
Cell Biology
Maud Wurmser, Mridula Muppavarapu, Christine Mary Tait, Christophe Laumonnerie, Luz Maria Gonzalez-Castrillon, Sara Ivy Wilson
Summary: The correct organization and connectivity of neurons rely on the complex development from neural stem cell domains, with a significant role played by Robo2, particularly during embryonic stages in influencing axon guidance and cell body migration of dI1 neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Samuel J. Barnes, Georg B. Keller, Tara Keck
Summary: This study used two-photon imaging to observe changes in neuronal synaptic calcium signals in awake mice, revealing that spines correlated with intrinsic network activity undergo TNF-α-dependent homeostatic enhancement, while spines responsive to sensory stimulation do not. Following sensory deprivation, global sensory-evoked responses increased, despite identified sensory inputs not strengthening.
Review
Cell Biology
Sara Palma-Tortosa, Berta Coll-San Martin, Zaal Kokaia, Daniel Tornero
Summary: Stem cell therapy using human skin-derived neural precursors shows promise for stroke treatment, with mechanisms including bystander effect and neuronal replacement/integration improving recovery in animal models. Advanced research tools provide solid evidence for these mechanisms, and clinical trials support the feasibility of stem cell-based neuronal replacement in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Hakan Aldskogius, Elena N. Kozlova
Summary: Unraveling the cellular and molecular mechanisms of spinal cord injury is crucial for developing successful therapeutic approaches. Experimental in vivo models play a critical role in exploring the clinical relevance of mechanistic findings and therapeutic innovations. Inducing different types of dorsal root injury at specific proximo-distal locations provides opportunities to distinguish key components underlying spinal cord regeneration failure.
Review
Biochemistry & Molecular Biology
Shoichiro Tani, Hiroyuki Okada, Ung-il Chung, Shinsuke Ohba, Hironori Hojo
Summary: Skeletal disorders, such as osteoarthritis and bone fractures, can greatly impact the quality of life for elderly individuals. Regenerative therapies using skeletal cells are a promising treatment option, with two main strategies for cell sources: induced pluripotent stem cells or extraction from skeletal tissues. These cells have the potential for differentiation into various skeletal cell types and offer applications for skeletal regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Susana Delgado Ocana, Dario Magaquian, Claudia Banchio
Summary: Extracellular vesicles (EVs) released by all cell types, including neural stem cells (NSCs), play a crucial role in intercellular communication. In this study, we demonstrated that NSC-derived EVs (NSC-EVs) enhance NSC proliferation, promote neuronal differentiation, and restore the proliferative potential of NSCs affected by oxidative stress. Furthermore, we found that NSC-EVs ameliorate damage burden in neurons induced by inflammation. These findings highlight the therapeutic potential of NSC-EVs in brain tissue regeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Yoshinobu Hirano, Takayuki Nakagomi, Akiko Nakano-Doi, Shuji Kubo, Yusuke Minato, Toshinori Sawano, Masafumi Sakagami, Kenzo Tsuzuki
Summary: We have previously shown that neural stem/progenitor cells (NSPCs) are induced in and around areas affected by ischemic stroke in mice. These injury/ischemia-induced NSPCs (iNSPCs) can differentiate into functional neurons in vitro, indicating a self-repair mechanism after injury. However, during the healing process, the ischemic areas are occupied by inflammatory cells, primarily microglial cells/macrophages (MGs/Mfs), and neurogenesis rarely occurs. To investigate the role of MGs/Mfs in regulating iNSPCs, we isolated iNSPCs from the ischemic areas and found that the presence of MGs/Mfs significantly reduces both the proliferation and differentiation of iNSPCs into neuronal cells, thus inhibiting neurogenesis. Depleting MG/Mfs using clodronate encapsulated in liposomes mitigated these effects. Our results suggest that regulating MGs/Mfs is crucial for achieving iNSPC-based neural regeneration after ischemic stroke.
Article
Multidisciplinary Sciences
Yupu Wang, Ruiling Zhang, Sihao Huang, Parisa Tajalli Tehrani Valverde, Meike Lobb-Rabe, James Ashley, Lalanti Venkatasubramanian, Robert A. Carrillo
Summary: Neuronal death and brain dysfunction are characteristics of aging and neurodegeneration. This study demonstrates that healthy neurons can compensate for the death of their neighbors through cross-neuron plasticity in the Drosophila larval neuromuscular system. The Draper engulfment receptor and the Shark kinase are found to be essential for this compensation, and overexpression of the Draper-I isoform enhances cross-neuron plasticity. These findings provide insights into how healthy bystander neurons respond to the loss of neighboring neurons.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Neng-Wei Tsai, Cheng-Chen Lin, Ti -Yen Yeh, Yu-An Chiu, Hsin-Hui Chiu, Hsiang -Po Huang, Sung -Tsang Hsieh
Summary: In this study, we established a cell system of iPSC-derived sensory neurons to model peripheral nerve degeneration and investigate the molecular mechanisms of neurodegeneration. We found that vincristine, a drug that causes chemotherapy-induced peripheral neuropathy, led to faster degeneration of neurites compared to somata, consistent with length-dependent neuropathy. Additionally, we discovered that JNK phosphorylation was upregulated, while p38 and ERK1/2 phosphorylation remained unchanged. Furthermore, vincristine treatment impaired autophagy and reduced autophagic flux, which could be reversed by rapamycin treatment. These findings not only provide insights into the molecular mechanisms of neurodegeneration but also offer potential therapeutic targets.
DISEASE MODELS & MECHANISMS
(2022)
Review
Chemistry, Multidisciplinary
Hefei Liu, Yuan Qin, Hung-Yu Chen, Jiangbin Wu, Jiahui Ma, Zhonghao Du, Nan Wang, Jingyi Zou, Sen Lin, Xu Zhang, Yuhao Zhang, Han Wang
Summary: This paper reviews the progress of artificial neuronal devices based on emerging volatile switching materials, focusing on the demonstrated neuron models implemented in these devices and their utilization for computational and sensing applications. Furthermore, it discusses the inspirations from neuroscience and engineering methods to enhance the neuronal dynamics that are yet to be realized in artificial neuronal devices and networks towards achieving the full functionalities of biological neurons.
ADVANCED MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Lindong Wu, Zongwei Wang, Lin Bao, Zhizhen Yu, Qingyu Chen, Yaotian Ling, Yabo Qin, Shengyu Bao, Zhuoya Chen, Guandong Bai, Yimao Cai, John Robertson, Ru Huang
Summary: This article examines the application of neuronal intrinsic plasticity in neural networks. By adjusting the tunable load resistor and stimulus intensity, the oscillatory threshold of artificial neurons is studied. The results demonstrate that neuronal intrinsic plasticity can improve the performance of neural networks.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Immunology
Zhenjie Ma, Weihao Li, Liujing Zhuang, Tieqiao Wen, Ping Wang, Hongmeng Yu, Yongliang Liu, Yiqun Yu
Summary: In this study, TMEM59 is identified as a critical regulator in maintaining and regenerating the olfactory epithelium. TMEM59 deletion leads to transcriptional changes, affecting genes associated with olfactory transduction and inflammatory/immune response. Loss of TMEM59 impairs olfactory functions, decreases proliferation, and promotes infiltration of inflammatory cells. TMEM59 also plays a role in the regeneration of the olfactory epithelium, with reduced proliferative cells and sensory neurons. Anti-inflammatory treatment can recover neuronal generation and olfactory functions, suggesting a potential therapy for olfactory dysfunction associated with inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Geriatrics & Gerontology
Derick Thompson, Abiodun E. Odufuwa, Catherine A. Brissette, John A. Watt
Summary: The loss of axonal regeneration capacity is a major issue following traumatic brain injury and is associated with age-related decline in neuronal plasticity. In this study, we characterized the molecular mechanisms underlying this phenomenon by analyzing the transcriptome and DNA methylome of the supraoptic nucleus in rats of different ages. Our findings suggest that age-related downregulation of axonogenesis-related genes and differential methylation patterns contribute to the loss of regenerative capabilities, while upregulation of MHCI-related transcripts and enrichment of AP-1 binding sites may play a role in this process.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Benjamin Liu, Michael J. Seay, Dean V. Buonomano
Summary: Research shows that different subpopulations of neurons in the complex cortical circuits can form neuronal ensembles with shared functional connectivity through chronic optogenetic stimulation. These ensembles exhibit changes such as decreased voltage correlation, synaptic decoupling between stimulated and nonstimulated populations, and decreased firing rate during Upstates in the stimulated population. These findings help understand the mechanisms of creating ensembles within cortical circuits through chronic patterned stimulation and demonstrate the preservation of functional distinct ensembles during Upstates through differential firing rates and correlations.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Damaris Nieves Torres, Sang H. Lee
Summary: Conventional inter-neuronal communication is wired and occurs through chemical synapses, but recent studies suggest that neurons can also communicate wirelessly through small extracellular vesicles (EVs). These small EVs, including exosomes, contain various signaling molecules and can be absorbed by recipient cells. Neuronal small EVs have been found to affect multiple neuronal functions. This volume transmission mediated by small EVs is important for activity-dependent changes in neuronal function and the regulation of local circuitry. In this review, recent discoveries and the potential scope of small EV-mediated inter-neuronal signaling are summarized.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell & Tissue Engineering
Joey Lau, Svitlana Vasylovska, Elena N. Kozlova, Per-Ola Carlsson
CELL TRANSPLANTATION
(2015)
Article
Multidisciplinary Sciences
Xuan Wang, Beichen Xie, Yu Qi, Ola Wallerman, Svitlana Vasylovska, Leif Andersson, Elena Nickolaevna Kozlova, Nils Welsh
SCIENTIFIC REPORTS
(2016)
Article
Clinical Neurology
Tanya Aggarwal, Jan Hoeber, Patrik Ivert, Svitlana Vasylovska, Elena N. Kozlova
Article
Cell & Tissue Engineering
Carl Trolle, Patrik Ivert, Jan Hoeber, Iris Rocamonde-Lago, Svitlana Vasylovska, Eugen Lukanidin, Elena N. Kozlova
REGENERATIVE MEDICINE
(2017)
Article
Cell & Tissue Engineering
Jan Hoeber, Niclas Konig, Carl Trolle, Emilia Lekholm, Chunfang Zhou, Stanislava Pankratova, Elisabet Akesson, Robert Fredriksson, Hakan Aldskogius, Elena N. Kozlova
STEM CELLS AND DEVELOPMENT
(2017)
Article
Cell Biology
Nikos Schizas, N. Konig, B. Andersson, S. Vasylovska, J. Hoeber, E. N. Kozlova, N. P. Hailer
CELL AND TISSUE RESEARCH
(2018)
Review
Biotechnology & Applied Microbiology
Letizia Mazzini, Daniela Ferrari, Pavle R. Andjus, Leonora Buzanska, Roberto Cantello, Fabiola De Marchi, Maurizio Gelati, Rashid Giniatullin, Joel C. Glover, Mariagrazia Grilli, Elena N. Kozlova, Margherita Maioli, Dinko Mitrecic, Augustas Pivoriunas, Rosario Sanchez-Pernaute, Anna Sarnowska, Angelo L. Vescovi
EXPERT OPINION ON BIOLOGICAL THERAPY
(2018)
Article
Neurosciences
Anastasiia Kosykh, Anongnad Ngarnjariyawat, Svitlana Vasylovska, Niclas Konig, Carl Trolle, Joey Lau, Arsen Mikaelyan, Michael Panchenko, Per-Ola Carlsson, Ekaterina Vorotelyak, Elena N. Kozlova
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2015)
Article
Cell & Tissue Engineering
Niclas Konig, Carl Trolle, Katarina Kapuralin, Igor Adameyko, Dinko Mitrecic, Hakan Aldskogius, Peter J. Shortland, Elena N. Kozlova
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Chemistry, Multidisciplinary
Alexander Omelyanchik, Valentina Antipova, Christina Gritsenko, Valeria Kolesnikova, Dmitry Murzin, Yilin Han, Andrei V. Turutin, Ilya V. Kubasov, Alexander M. Kislyuk, Tatiana S. Ilina, Dmitry A. Kiselev, Marina I. Voronova, Mikhail D. Malinkovich, Yuriy N. Parkhomenko, Maxim Silibin, Elena N. Kozlova, Davide Peddis, Kateryna Levada, Liudmila Makarova, Abdulkarim Amirov, Valeria Rodionova
Summary: Polymer-based magnetoelectric composite materials show high potential in various applications such as magnetic field sensors, energy harvesting, and biomedical devices. Current research focuses on increasing the efficiency of magnetoelectric transformation. Strategies such as clustering magnetic nanoparticles and incorporating piezoelectric particles have been proposed to enhance the alpha ME value of the magnetoelectric effect.
Review
Cell Biology
Hakan Aldskogius, Elena N. Kozlova
Summary: Unraveling the cellular and molecular mechanisms of spinal cord injury is crucial for developing successful therapeutic approaches. Experimental in vivo models play a critical role in exploring the clinical relevance of mechanistic findings and therapeutic innovations. Inducing different types of dorsal root injury at specific proximo-distal locations provides opportunities to distinguish key components underlying spinal cord regeneration failure.
Article
Neurosciences
Francesco Latini, Johanna Martensson, Elna-Marie Larsson, Mats Fredrikson, Fredrik Ahs, Mats Hjortberg, Haan Aldskogius, Mats Ryttlefors