Article
Environmental Sciences
Meng Li, Jing Feng, Ying Cheng, Nisha Dong, Xiaolin Tian, Penghui Liu, Yannan Zhao, Yulan Qiu, Fengjie Tian, Yi Lyu, Qian Zhao, Cailing Wei, Meng Wang, Jiyu Yuan, Xiaodong Ying, Xuefeng Ren, Xiaoyan Yan
Summary: Exposure to arsenic and fluoride induced early apoptosis and endoplasmic reticulum expansion in myocardial cells. Endoplasmic reticulum stress (ERS) and apoptosis pathways were involved in the damage caused by co-exposure to arsenic and fluoride.
Article
Toxicology
Qianqian Xiao, Xiaohong Hou, Chenping Kang, Linglu Xu, Lilan Yuan, Zhe Zhao, Qinghe Meng, Jianjun Jiang, Weidong Hao
Summary: Chlorocholine chloride (CCC) is a plant growth regulator with potential as an environmental endocrine disrupting chemical. In this study, it was found that CCC exposure inhibited testosterone secretion in Sprague-Dawley rats Leydig cells, possibly through inducing endoplasmic reticulum (ER) stress. The increase in ER stress-related protein levels caused by CCC exposure could be alleviated by treatment with an ER stress inhibitor, which rescued the testosterone secretion disorders.
TOXICOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Juan Ignacio Elio Mariangelo, Carlos Alfredo Valverde, Leticia Vittone, Matilde Said, Cecilia Mundina-Weilenmann
Summary: This study found that blocking ER calcium efflux via the translocon can suppress ER stress and improve the mechanical performance and diastolic calcium handling of stunned myocardium. Therefore, modulation of translocon permeability may be a therapeutic approach to treat the functional abnormalities caused by ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Shizhen Qin, Rui Wang, Defu Tang, Shijiao Qin, Yanli Guo, Zhaoguo Shi
Summary: The study found that manganese (Mn) can reduce oxidative stress induced by heat stress and exert antiapoptotic effects by increasing MnSOD enzymatic activity. Additionally, Mn can lower oxidative stress levels by activating the nuclear factor E2-related factor 2 (NRF2)/SOD2 signaling pathway, thereby protecting myocardial cells during embryonic development.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Chemistry, Medicinal
Samira Aouichat, Miguel Navarro-Alarcon, Pablo Alarcon-Guijo, Diego Salagre, Marwa Ncir, Lazhar Zourgui, Ahmad Agil
Summary: The study demonstrated that melatonin can play a renoprotective role by suppressing ER stress and the pro-apoptotic IRE1α/JNK signaling pathway.
Article
Toxicology
Byung Sik Kim, In-Hwa Park, A-Hyeon Lee, Hyun-Jin Kim, Young-Hyo Lim, Jeong-Hun Shin
Summary: Sacubitril/valsartan protects against doxorubicin-induced cardiotoxicity by reducing endoplasmic reticulum stress and apoptosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Linjing Deng, Yongsheng Ma, Ping Ma, Yang Wu, Xu Yang, Qihong Deng
Summary: The study revealed that exposure to cooking oil fumes had significant toxic effects on the respiratory system of rats, including oxidative stress, activation of apoptosis factors, and endoplasmic reticulum stress. Vitamin E could effectively alleviate lung injury caused by exposure to cooking oil fumes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Pharmacology & Pharmacy
Huijie Zhao, Xiaodi Fu, Yanting Zhang, Yihan Yang, Honggang Wang
Summary: Endoplasmic reticulum (ER) plays a critical role in protein synthesis and processing. When ER is overloaded with misfolded proteins, ER stress is triggered. Hydrogen sulfide (H2S) has been recognized as an important gas signal molecule, with regulatory effects on various physiological and pathological processes. This review focuses on the role of H2S in regulating ER stress in myocardial diseases, aiming to provide a better understanding of its mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francisco Souza-Neto, Fabian Islas, Sara Jimenez-Gonzalez, Maria Luaces, Bunty Ramchandani, Ana Romero-Miranda, Beatriz Delgado-Valero, Elena Roldan-Molina, Melchor Saiz-Pardo, Ma Angeles Ceron-Nieto, Luis Ortega-Medina, Ernesto Martinez-Martinez, Victoria Cachofeiro
Summary: This study evaluated the cardiac function and fibrosis in infarcted rats treated with MitoQ and in patients with acute myocardial infarction. The results showed that MitoQ reduced oxidative stress and improved cardiac function, and also decreased fibrosis by inhibiting endoplasmic reticulum stress.
Article
Environmental Sciences
Li Ma, Sirao Hai, Chenlong Wang, Chuangjiang Chen, Sajid Ur Rahman, Chang Zhao, Mansoor Ahmed Bazai, Shibin Feng, Xichun Wang
Summary: This study aimed to investigate the molecular mechanism of Zearalenone (ZEA)-induced dysfunction of mitochondria-associated endoplasmic reticulum membranes (MAM) in piglet Sertoli cells (SCs) through the endoplasmic reticulum stress (ERS) pathway. The results showed that ZEA damaged cell viability, disrupted MAM structure, and altered protein expression of various markers related to MAM function. The inhibition of ERS reduced the cytotoxicity of ZEA and restored the normal function of MAM in SCs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Xin Wen, Bin Su, Mingming Gao, Jiaqi Chen, Donglei Zhou, Hui You, Nannan Li, Shuaikang Chang, Xiaoyun Cheng, Chunhua Qian, Jingyang Gao, Peng Yang, Shen Qu, Le Bu
Summary: Our study reveals that lipocalin 2 (LCN2) plays a protective role in obese individuals, inhibiting cell apoptosis and improving inflammatory state by repressing endoplasmic reticulum stress, thereby alleviating gastric injury associated with obesity.
CELL DEATH & DISEASE
(2021)
Article
Microbiology
Maria Naama, Shahar Telpaz, Aya Awad, Shira Ben-Simon, Sarina Harshuk-Shabso, Sonia Modilevsky, Elad Rubin, Jasmin Sawaed, Lilach Zelik, Mor Zigdon, Nofar Asulin, Sondra Turjeman, Michal Werbner, Supapit Wongkuna, Rachel Feeney, Bjoern O. Schroeder, Abraham Nyska, Meital Nuriel-Ohayon, Shai Bel
Summary: Colonic goblet cells secrete mucus to protect against bacterial invasion and inflammation. Activation of autophagy in mice via Beclin 1 reduces endoplasmic reticulum (ER) stress, leading to thicker and less penetrable mucus production. This ER-stress-mediated regulation of mucus secretion is dependent on the microbiota and the Nod2 gene, and it plays a critical role in maintaining intestinal homeostasis.
CELL HOST & MICROBE
(2023)
Article
Biochemistry & Molecular Biology
Huan Xia, Yongmei Wang, Jie Dai, Xin Zhang, Jun Zhou, Zhu Zeng, Yi Jia
Summary: Selenoprotein K is crucial for the migration and phagocytosis of dendritic cells, and its effects are related to endoplasmic reticulum stress levels and calcium ion concentration.
Article
Engineering, Environmental
Huanliang Liu, Wenqing Lai, Xiaohua Liu, Honglian Yang, Yanjun Fang, Lei Tian, Kang Li, Huipeng Nie, Wei Zhang, Yue Shi, Liping Bian, Susu Ding, Jun Yan, Bencheng Lin, Zhuge Xi
Summary: The research investigated the mechanism of hepatotoxicity and apoptosis caused by Nano-CuO through oxidative stress and ER-stress. Both in vivo and in vitro experiments confirmed that Nano-CuO induced oxidative stress, leading to ER-stress pathway activation and subsequently cell death.
JOURNAL OF HAZARDOUS MATERIALS
(2021)