Hippo Tips the TGF-β Scale in Favor of Pluripotency

How TGF-beta signaling switches from enforcing pluripotency to promoting mesendodermal differentiation remains an open question. Recently in Cell Reports, Beyer et al. demonstrated that Hippo signaling components recruit the NuRD complex to repress expression of key genes targeted by TGF-beta and thus determine whether TGF-beta signaling will favor pluripotency or differentiation.