Article
Multidisciplinary Sciences
Johann-Christoph Jann, Maximilian Mossner, Vladimir Riabov, Eva Altrock, Nanni Schmitt, Johanna Flach, Qingyu Xu, Verena Nowak, Julia Oblaender, Iris Palme, Nadine Weimer, Alexander Streuer, Ahmed Jawhar, Ali Darwich, Mohammad Jawhar, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak
Summary: Exome sequencing revealed mutations in bone marrow-derived MSCs from patients with myelodysplastic syndrome (MDS), but validation experiments indicate these mutations are secondary to in vitro expansion rather than primary mutations in the BM.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Chloe Friedrich, Olivier Kosmider
Summary: This article discusses the role of the mesenchymal niche in the pathophysiology of Myelodysplastic syndromes (MDS) and provides an overview of currently available in vitro and in vivo models that can be used to study the effects of the mesenchymal niche on hematopoietic stem cells (HSCs).
Article
Oncology
Margot F. van Spronsen, Diana Hanekamp, Theresia M. Westers, Noortje van Gils, Eline Vermue, Arjo Rutten, Joop H. Jansen, Birgit I. Lissenberg-Witte, Linda Smit, Gerrit J. Schuurhuis, Arjan A. van de Loosdrecht
Summary: Myelodysplastic syndromes (MDS) are hematological disorders originating from neoplastic transformation of hematopoietic stem cells (HSCs). This study highlights the presence of immunophenotypic aberrant HSCs (IA-HSCs) in MDS-derived bone marrows (MDS-BMs), which predict leukemic progression and show potential as a prognostic biomarker. IA-HSCs are associated with perturbed hematopoiesis and independent of conventional risk factors. The sensitivity and specificity of IA-HSCs for predicting leukemic progression at 2 years follow-up were 83% and 71%, respectively.
Editorial Material
Biochemistry & Molecular Biology
Magda Bienko
Summary: A new study demonstrates the connection between two long non-coding RNAs and the transcriptional activation of the therapeutic target miR-10b in glioblastoma multiforme by linking a distal enhancer to the HOXD3/D4/miR-10b gene promoter.
Review
Oncology
Pawel Swietach, Ebbe Boedtkjer, Stine Falsig Pedersen
Summary: Changes in proton concentration and sensing play a crucial role in cancer progression by influencing protein activity and pH balance. The acidic microenvironment of tumors, caused by metabolic changes, affects various aspects of tumor biology and accelerates disease progression. Targeting acid-base disturbances in cancer presents potential therapeutic opportunities.
NATURE REVIEWS CANCER
(2023)
Review
Genetics & Heredity
Chiara Chiereghin, Erica Travaglino, Matteo Zampini, Elena Saba, Claudia Saitta, Elena Riva, Matteo Bersanelli, Matteo Giovanni Della Porta
Summary: Myelodysplastic syndromes (MDS) are clonal diseases driven by a complex combination of genetic mutations, resulting in ineffective hematopoiesis and an increased risk of progression to acute myeloid leukemia. These mutations can be categorized into a limited number of cellular pathways, influencing clinical phenotype, disease progression, and prognosis.
Review
Immunology
Likun Zheng, Lei Zhang, Yixuan Guo, Xintong Xu, Zhaoyun Liu, Zhenyu Yan, Rong Fu
Summary: Myelodysplastic syndrome (MDS) is a common hematological malignant disease characterized by abnormal proliferation of malignant hematopoietic stem cells in the bone marrow. The dysfunction of mesenchymal stromal cells (MSCs) in the bone marrow microenvironment plays a critical role in MDS progression through modulation of immune cell function, enabling evasion of immune surveillance by MDS-associated malignant cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Zhaoyun Liu, Yixuan Guo, Lei Huang, Yue Jia, Hui Liu, Fengping Peng, Lixiang Duan, Hongkai Zhang, Rong Fu
Summary: This study found that MDS patients have reduced number and function of NK cells. Further research showed that TIGIT is the most highly expressed marker on NK cells, and the expression of CD155 on BMSCs is significantly higher than CD112 and CD113.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
C. Giallongo, I. Dulcamare, S. Giallongo, A. Duminuco, D. Pieragostino, M. C. Cufaro, A. M. Amorini, G. Lazzarino, A. Romano, N. Parrinello, M. Di Rosa, G. Broggi, R. Caltabiano, M. Caraglia, M. Scrima, L. S. Pasquale, M. S. Tathode, G. Li Volti, R. Motterlini, F. Di Raimondo, D. Tibullo, G. A. Palumbo
Summary: Ineffective hematopoiesis is a characteristic of myelodysplastic syndromes (MDS) and is closely related to epigenetic changes in the mesenchymal stromal cell (MSC) compartment. This study reveals that the histone variant macroH2A1 (mH2A1) regulates the interaction between epigenetics and inflammation in MDS-MSCs, potentially affecting their hematopoietic support ability. The findings suggest that the mH2A1.1 isoform and Toll-like receptor 4 (TLR4) play a key role in the crosstalk between epigenetic signaling, inflammation, and cell metabolism networks in MDS-MSCs.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Yang Mei, Kehan Ren, Yijie Liu, Annabel Ma, Zongjun Xia, Xu Han, Ermin Li, Hamza Tariq, Haiyan Bao, Xinshu Xie, Cheng Zou, Dingxiao Zhang, Zhaofeng Li, Lili Dong, Amit Verma, Xinyan Lu, Yasmin Abaza, Jessica K. Altman, Madina Sukhanova, Jing Yang, Peng Ji
Summary: This study reveals that age-related MDS can transform into AML, and the cytokine IL-6 plays a significant role in this transformation. By studying a double knockout mouse model and high-risk MDS patients, blocking IL-6 signaling was found to significantly ameliorate AML progression, indicating the clinical significance of targeting IL-6 signaling in treating high-risk MDS.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Yasushige Aoyagi, Yoshihiro Hayashi, Yuka Harada, Kwangmin Choi, Natsumi Matsunuma, Daichi Sadato, Yuki Maemoto, Akihiro Ito, Shigeru Yanagi, Daniel T. Starczynowski, Hironori Harada
Summary: We demonstrated that excessive mitochondrial fragmentation is a fundamental pathobiological phenomenon that could trigger dysplasia formation and ineffective hematopoiesis in MDS. Our findings provide mechanistic insights into ineffective hematopoiesis and suggest dysregulated mitochondrial dynamics as a therapeutic target for treating MDS.
Article
Information Science & Library Science
Angel Borrego, Lluis Anglada, Ernest Abadal
Summary: Transformative agreements, also known as offsetting, read and publish, or publish and read agreements, have shifted the focus of scholarly journal licensing towards open access publication. These agreements offer more transparency, allow authors to retain copyright, and are categorized into pre-transformative, partially transformative, and fully transformative agreements.
LEARNED PUBLISHING
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Calvin A. Henard
Summary: Methanotrophic bacteria are utilized in industries as catalysts to convert methane into valuable products. A significant study by Kalyuzhnaya et al. discovered the main metabolic pathway for methane conversion in an industrially promising methanotroph, providing a comprehensive understanding of methanotrophy at a systems-level.
TRENDS IN BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Georgia Sotiropoulou, Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis
Summary: Proteases are regulated enzymes that can be detected and quantified using activity-based probes (ABPs), which have potential applications in molecular imaging, diagnosis, and therapy.
Review
Medicine, General & Internal
Petter S. Woll, Tetsuichi Yoshizato, Eva Hellstrom-Lindberg, Thoas Fioretos, Benjamin L. Ebert, Sten Eirik W. Jacobsen
Summary: The genetic architecture of cancer has been extensively studied, leading to the identification of new therapeutic targets and the development of promising treatment strategies. However, disease progression, relapse, and treatment-related mortality remain challenging in certain types of cancer such as myelodysplastic syndromes and acute myeloid leukemia. The persistence of rare leukemic stem cells following therapy underscores the resistance mechanisms of these cells and their role in relapse. To improve treatment strategies, there is a need to better understand and characterize the stem cells associated with these diseases at the cellular, molecular, and genetic levels.
JOURNAL OF INTERNAL MEDICINE
(2022)
