Article
Cardiac & Cardiovascular Systems
Natalie R. Harris, Natalie R. Nielsen, John B. Pawlak, Amir Aghajanian, Krsna Rangarajan, D. Stephen Serafin, Gregory Farber, Danielle M. Dy, Nathan P. Nelson-Maney, Wenjing Xu, Disha Ratra, Sophia H. Hurr, Li Qian, Joshua P. Scallan, Kathleen M. Caron
Summary: This study reveals the essential role of VE-cadherin in the development and maintenance of cardiac lymphatics and its impact on lymphangiogenic signaling pathways. Surprisingly, despite the regression of cardiac lymphatics, Cdh5(flox/flox);Prox1CreER(T2) mice exhibited preserved cardiac function at baseline and after myocardial infarction compared with control mice. Mechanistically, loss of VE-cadherin leads to aberrant cellular internalization of VEGFR3, impairing downstream processes such as cellular proliferation.
CIRCULATION RESEARCH
(2022)
Editorial Material
Cell Biology
Ann Sanoji Samarakkody, Alan B. Cantor
Summary: The study reveals the mechanism by which RUNX1 collaborates with TGF beta signaling transcription factors to drive chromatin accessibility changes that specify hemogenic endothelial cells (HECs). It also highlights interesting parallels between hematopoietic transition (EHT) and endothelial-to-mesenchymal transition (EndoMT) during cardiac development.
GENES & DEVELOPMENT
(2021)
Article
Neurosciences
Hannah L. Gillis, Alena Kalinina, Yingben Xue, Keqin Yan, Valerie Turcotte-Cardin, Matthew A. M. Todd, Kevin G. Young, Diane Lagace, David J. Picketts
Summary: The high incidence of ischemic stroke and lack of effective neuroprotective drugs have led to the need for novel therapies in stroke recovery. VGF, a neurosecretory protein, has been identified as important for stroke recovery. Knockout mice lacking VGF demonstrated impaired recovery and reduced migration of immature neurons, which could be rescued by exogenous delivery of VGF peptides.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Genetics & Heredity
Zuohua Chi, Liji Chen, Xiaomin Ye, Aimei Liu, Gongwang Yu, Yan Sun
Summary: Endothelial cells and perivascular cells together form a diverse network of blood vessels in the bone marrow, facilitating the delivery of blood cells, oxygen, and nutrients. These vessels create niches for hematopoietic stem and progenitor cells, providing signals for cell homing, self-renewal, and differentiation. Understanding the structure and function of the bone marrow vasculature niche is essential for developing advanced strategies in hematopoiesis reconstitution.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Geochemistry & Geophysics
Yanan Tian, Ting Lin, Yue Li, Ning Wu
Summary: DAS is a new downhole seismic acquisition technology with advantages of low cost, sensitive signal capture capability, and high spatial-temporal resolution. However, noise pollution poses a challenge. To address this, a sparse parallel-subnet network (SPSNet) is designed to suppress noise and recover signals.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2022)
Review
Immunology
Balaji Balakrishnan, Uday Prakash Kulkarni, Aswin Anand Pai, Raveen Stephen Stallon Illangeswaran, Ezhilpavai Mohanan, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian
Summary: Hematopoietic cell transplantation (HCT) is an effective treatment for hematological diseases, but early complications such as GVHD and SOS limit its success. Research has focused on discovering blood-based biomarkers to diagnose and predict complications and therapy response. However, these biomarkers are not yet used in routine clinical practice. This review summarizes the biomarkers for early complications post-HCT, ongoing trials, and challenges in using them.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Brisa Palikuqi, Jeremie Rispal, Efren A. Reyes, Dedeepya Vaka, Dario Boffelli, Ophir Klein
Summary: The intestinal epithelium can continuously renew and regenerate, and the proliferation and maintenance of intestinal stem cells (ISCs) are regulated by their surrounding niche cells. In this study, lymphatic endothelial cells (LECs) were found to play an essential role in supporting epithelial renewal and repair by secreting molecules in close proximity to crypt epithelial cells. LECs were identified as a crucial source of Wnt signaling in the small intestine, and their loss hindered recovery after cytotoxic injury.
Editorial Material
Hematology
Simon Mendez-Ferrer
Summary: Lou et al. demonstrate that ATRA and various inflammatory signals upregulate the expression of RIG-I in BMSCs. This leads to a decrease in their ROS buffering capacity and hematopoietic supportive function post-transplantation.
Article
Medicine, Research & Experimental
Alhomidi Almotiri, Hamed Alzahrani, Juan Bautista Menendez-Gonzalez, Ali Abdelfattah, Badi Alotaibi, Lubaid Saleh, Adelle Greene, Mia Georgiou, Alex Gibbs, Amani Alsayari, Sarab Taha, Leigh-anne Thomas, Dhruv Shah, Sarah Edkins, Peter Giles, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Ashleigh S. Boyd, Florian A. Siebzehnrubl, Neil P. Rodrigues
Summary: The study suggests that loss of Zeb1 in adult stem cells leads to significant defects in stem cell renewal and differentiation, which are associated with leukemia signaling. Therefore, Zeb1 plays a crucial role as a transcriptional regulator in hematopoiesis, coordinating HSC self-renewal and differentiation to suppress the potential development of AML.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Lijian Shao, Na Yoon Paik, Mark A. Sanborn, Thilinie Bandara, Anjali Vijaykumar, Kilian Sottoriva, Jalees Rehman, Cesar Nombela-Arrieta, Kostandin V. Pajcini
Summary: Notch signaling is crucial for the emergence and development of definitive hematopoietic stem cells (HSCs) in the embryo and fetal liver. This study reveals endothelial Jagged1 (Jag1) as a critical factor in early fetal liver vascular development but not essential for fetal HSC expansion. Jag1 is expressed in various hematopoietic cells in the fetal liver, including HSCs, but lost in adult bone marrow HSCs. Deletion of hematopoietic Jag1 does not impact fetal liver development, but results in a significant transplantation defect in fetal liver HSCs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Qinqin Peng, Ke Sha, Yingzi Liu, Mengting Chen, San Xu, Hongfu Xie, Zhili Deng, Ji Li
Summary: The study found that angiogenesis was enhanced in both rosacea patients and LL37-induced rosacea-like mice, with inhibition of angiogenesis alleviating rosacea-like features. Activation of mTORC1 in endothelial cells was observed in the lesional skin, and inhibiting mTORC1 decreased angiogenesis and blocked rosacea development. In vitro results showed that inhibiting mTORC1 signaling significantly decreased LL37-induced tube formation of human endothelial cells, suggesting that targeting angiogenesis may be a potential therapy for rosacea.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Zi-Yi Zhou, Lin Wang, Yu-Sheng Wang, Guo-Rui Dou
Summary: The current treatment for ocular pathological angiogenesis focuses on anti-VEGF signals, but regulation of endothelial glycolysis has emerged as a potential treatment targeting vessel sprouting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Pranjal Dutta, Mahesh Sreekumar Rajasree, Santanu Sarkar
Summary: This paper studies the NIST lightweight 3rd round candidate TinyJAMBU and analyzes its core component, the keyed permutation P-n. It discovers good cubes that can be used to build distinguishers and determines that TinyJAMBU is secure against distinguishers using 32 sized cubes for more than 445 rounds. The paper also presents new key-recovery attacks based on the concept of monomial trail.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Haotian Zhang, Amar Yeware, Sandy Lee, Huichun Zhan
Summary: This study demonstrates that a murine model with both JAK2V617F-bearing hematopoietic cells and JAK2V617F-bearing vascular ECs can recapitulate key features of human MPN disease. The findings suggest that the spleen plays a crucial role in JAK2V617F mutant neoplastic hematopoiesis during aging and MPN disease progression. Additionally, the presence of JAK2V617F-bearing vascular ECs may contribute to both hematologic and cardiovascular abnormalities in MPN.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Melanie Jannaway, Drishya Iyer, Diandra M. Mastrogiacomo, Kunyu Li, Derek C. Sung, Ying Yang, Mark L. Kahn, Joshua P. Scallan
Summary: Research shows that the loss of Flt4 specifically in lymphatic cells inhibits the formation of specialized button junctions in multiple tissues and impairs interstitial absorption. Knockdown of FLT4 in human lymphatic endothelial cells results in disrupted NOTCH1 expression and activation, while overexpression of the NOTCH1 intracellular domain in Flt4 knockout vessels rescues the formation of button junctions and absorption of interstitial molecules. These findings reveal the importance of VEGFR3 and NOTCH1 signaling in the development of button junctions during postnatal development and may have clinical implications for lymphatic diseases with impaired VEGFR3 signaling.
Review
Hematology
Allison J. Li, Laura M. Calvi
EXPERIMENTAL HEMATOLOGY
(2017)
Article
Immunology
D. Oleksyn, J. Zhao, A. Vosoughi, J. C. Zhao, R. Misra, A. P. Pentland, D. Ryan, J. Anolik, C. Ritchlin, J. Looney, A. P. Anandarajah, G. Schwartz, L. M. Calvi, M. Georger, C. Mohan, I. Sanz, L. Chen
IMMUNOLOGY LETTERS
(2017)
Article
Endocrinology & Metabolism
Rialnat A. Lawal, Xichao Zhou, Kaylind Batey, Corey M. Hoffman, Mary A. Georger, Freddy Radtke, Matthew J. Hilton, Lianping Xing, Benjamin J. Frisch, Laura M. Calvi
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Hematology
Sarah E. Latchney, Laura M. Calvi
SEMINARS IN HEMATOLOGY
(2017)
Review
Endocrinology & Metabolism
Corey M. Hoffman, Jimin Han, Laura M. Calvi
Article
Multidisciplinary Sciences
Rhonda J. Staversky, Daniel K. Byun, Mary A. Georger, Brandon J. Zaffuto, Alexandra Goodman, Michael W. Becker, Laura M. Calvi, Benjamin J. Frisch
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
NATURE COMMUNICATIONS
(2018)
Review
Hematology
Titas Banerjee, Laura M. Calvi, Michael W. Becker, Jane L. Liesveld
Editorial Material
Endocrinology & Metabolism
Laura M. Calvi, Lorenz C. Hofbauer
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Biology
Laura M. Calvi, Benjamin J. Frisch, Paul D. Kingsley, Anne D. Koniski, Tanzy M. Love, Jacqueline P. Williams, James Palis
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Oncology
Mitra Azadniv, Jason R. Myers, Helene R. McMurray, Naxin Guo, Phil Rock, Myra L. Coppage, John Ashton, Michael W. Becker, Laura M. Calvi, Jane L. Liesveld
Editorial Material
Endocrinology & Metabolism
Laura M. Calvi
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Editorial Material
Hematology
Laura M. Calvi
Summary: This study highlights the novel role of FGF-23 in G-CSF-stimulated mobilization of HSPCs, shedding light on the connection between phosphate metabolism and hematopoietic stem cells.
Article
Oncology
Allison N. Seyfried, Amanda McCabe, Julianne N. P. Smith, Laura M. Calvi, Katherine C. MacNamara
Summary: Our research has identified CCR5 signaling as a key axis promoting the development of IFN gamma-dependent bone marrow failure, particularly relevant in aging where Ccr5 expression is elevated.
Article
Medicine, Research & Experimental
Benjamin J. Frisch, Corey M. Hoffman, Sarah E. Latchney, Mark W. LaMere, Jason Myers, John Ashton, Allison J. Li, Jerry Saunders, James Palis, Archibald S. Perkins, Amanda McCabe, Julianne N. P. Smith, Kathleen E. McGrath, Fatima Rivera-Escalera, Andrew McDavid, Jane L. Liesveld, Vyacheslav A. Korshunov, Michael R. Elliott, Katherine C. MacNamara, Michael W. Becker, Laura M. Calvi
