Article
Oncology
Yujing Huang, Ying Liu, Jing Huang, Lu Gao, Zhenggang Wu, Lu Wang, Lin Fan
Summary: This study discovered that let-7b-5p promotes cell apoptosis in PD by targeting HMGA2, providing a potential theoretical basis for effective therapy in PD.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biology
Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah
Summary: Ponnusamy et al identified let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy using next generation sequencing of dried blood spots. They demonstrated that let-7b-5p exerts its effects through the Hippo-YAP pathway in cell culture and murine models of perinatal brain injury, indicating the need for validation in larger neonate cohorts to confirm its role as a biomarker for neonatal encephalopathy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena Montano, Alessandra Pollice, Valeria Lucci, Geppino Falco, Ornella Affinito, Girolama La Mantia, Maria Vivo, Tiziana Angrisano
Summary: Identification of molecular mechanisms controlling early cell fate decisions in mammals is crucial for potential therapies. Ink4a and Arf from the Cdkn2a locus mark an early pancreatic cellular state resembling Pancreatic Progenitor Cells (PPCs). Chromatin remodeling may play a role in regulating the CDKN2a locus during pancreatic lineage commitment.
Article
Dentistry, Oral Surgery & Medicine
Feifei Xue, Hongjie Feng, Tianxiao Wang, Guanying Feng, Nan Ni, Ruixia Wang, Hua Yuan
Summary: This study found that hsa_circ_0000264 is upregulated in head and neck squamous cell carcinoma (HNSCC) and promotes HNSCC progression by upregulating the expression of high mobility group AT-hook 2 (HMGA2) through sponging hsa-let-7b-5p. hsa_circ_0000264 may serve as a potential target for HNSCC treatment.
Article
Anatomy & Morphology
Xiao Zhang, Weiwei Sun, Weijie Wu, Minhao Chen, Tianyi Ji, Hua Xu, Youhua Wang
Summary: This study investigated the role of Pin1 in the aging of rat knee joint CSPCs. The results showed that Pin1 protein levels were reduced, and senescence-related markers were elevated in long-term in vitro culture. Over-expression of Pin1 reversed cellular senescence, while Pin1 siRNA incorporation promoted senescence. Pin1 deficiency resulted in cell cycle arrest in the G1 phase, indicating lack of proliferation ability, a sign of cellular senescence.
Article
Cell Biology
Xianglan Liu, Shufeng Li, Yi Yang, Yong Sun, Qingyuan Yang, Nan Gu, Jing Li, Tuo Huang, Ying Liu, Hui Dong, Song Sun, Guosheng Fu, Jian Wu, Bo Yu
Summary: The study investigated the expression of ANRIL in patients with coronary artery disease and its effect on endothelial dysfunction. The findings suggest that ANRIL is associated with markers of endothelial dysfunction and may regulate HUVEC dysfunction through the TGF-beta R1/Smad signaling pathway. This highlights a potential new therapeutic strategy for preventing endothelial dysfunction in cardiovascular disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Food Science & Technology
Wen-Ting Chen, Meei-Ju Yang, Yi-Wei Tsuei, Tsung-Chen Su, An-Ci Siao, Yow-Chii Kuo, Ling-Ru Huang, Yi Chen, Sy-Jou Chen, Po-Chuan Chen, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: This study investigates the effect of epigallocatechin gallate (EGCG) on the growth of white and beige preadipocytes by modulating the miR-let-7a and HMGA2 pathways. The results show that EGCG inhibits the growth of 3T3-L1 and D12 preadipocytes, upregulates miR-let-7a expression, and downregulates HMGA2 mRNA and protein levels. Overexpression of miR-let-7a and HMGA2 antagonizes the inhibitory effects of EGCG on cell growth. Therefore, EGCG acts on preadipocytes through the miR-let-7a/HMGA2 pathway to inhibit their growth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Cell Biology
Umer Farooq, Dimple Notani
Summary: 9p21 locus is a highly reproducible region in genome-wide association studies (GWAS) and is associated with various diseases and cancers. The genes within this region, including CDKN2A/B genes, play critical roles in cell cycle regulation and are linked to cellular regeneration, stemness, aging, and cancers. Understanding the regulation of these genes through promoter-driven and distal mechanisms could provide insights for targeting this locus in pathologies and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Mathematical & Computational Biology
Tianyi Cao, Junyi Hong, Feicheng Qi, Bo Zheng, Guofang Chen, Binjia Yu, Fusheng Ye
Summary: This study investigates the mechanisms by which diabetes affects tendon-to-bone healing. It reveals that a hyperglycemic microenvironment upregulates let-7b-5p, which inhibits CFTR transcription and subsequently impairs TDSC proliferation. This study provides insights into the potential mechanism behind poor tendon-to-bone healing in diabetes.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Cell Biology
Si-Yang Wang, Yue Xu, Quan Hong, Xiang-Mei Chen, Guang-Yan Cai
Summary: This study demonstrated that aged mice are more susceptible to AKI injury and identified an important role for the upregulation of the senescence-associated DNA damage/p53 pathway in this susceptibility. MSC treatment can reduce the degree of DNA damage and apoptosis. Furthermore, downregulation of let-7b-5p may lead to increased renal AKI susceptibility, and the presence of let-7b-5p in MSC-derived Exos can alleviate tubular epithelial cell apoptosis by inhibiting p53.
CELL AND TISSUE RESEARCH
(2022)
Article
Neurosciences
Ye Hong, Jinfeng Lyu, Lin Zhu, Xixi Wang, Mengna Peng, Xiangliang Chen, Qiwen Deng, Jie Gao, Zhenhua Yuan, Di Wang, Gelin Xu, Mengyi Xu
Summary: In this study, it was found that high-frequency rTMS alleviated ischemic stroke injury by inhibiting M1 microglia polarization through the regulation of the let-7b-5p/HMGA2/NF-kappa B signaling pathway. This led to a reduction in ischemic volumes and promotion of neurological recovery.
Article
Health Care Sciences & Services
Huiping Feng, Ling He, Zihua Wang, Bin Pi, Zhihua Liu
Summary: This study investigates the positive effects of phillygenin on intestinal tight junctions through the let-7b signaling pathway and regulation of intestinal microbiota. Results show that phillygenin can protect the intestinal barrier and maintain the expression of tight junction-associated proteins. Clinical samples confirm the regulatory role of phillygenin on let-7b levels.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Yin Zhuang, Sheng Song, Dan Xiao, Xueguang Liu, Xiaofei Han, Shihao Du, Yuan Li, Yanming He, Shujun Zhang
Summary: The pathogenesis of intervertebral disc degeneration is still unclear. In this study, it was found that exosomes secreted by degenerative intervertebral disc-derived nucleus pulposus stem cells could exacerbate annulus fibrosus cell degeneration. This effect was mediated by the let-7b-5p miRNA, which inhibited cell proliferation, migration, and matrix synthesis, and promoted apoptosis. The activation of the IGF1R expression and PI3K-Akt pathway were also inhibited by let-7b-5p.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Yuyang Dai, Jinsong Liu, Xuyan Li, Jianzhong Deng, Cheng Zeng, Wenbin Lu, Yongzhong Hou, Ying Sheng, Honglin Wu, Qian Liu
Summary: This research aims to investigate the regulatory network of NKD1 and miRNAs in colon cancer. The study identified let-7b-5p as a miRNA that can inhibit colon cancer cell proliferation, migration, and invasion by targeting NKD1. Further analysis revealed that NKD1 enhances colon cancer cell proliferation and migration by inhibiting APC expression.
Article
Oncology
Yongmeng Li, Rui Dong, Ming Lu, Chuanle Cheng, Zitong Feng, Renchang Zhao, Jinghui Liang, Jingyi Han, Jin Jiang, Meng Xu-Welliver, Stephane Renaud, Hui Tian
Summary: Let-7b-3p, downregulated in lung adenocarcinoma cells and tissues, is associated with poor prognosis in patients. It inhibits proliferation and metastasis of lung adenocarcinoma cells by targeting the BRF2-mediated MAPK/ERK pathway.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
