Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

USP7: Target Validation and Drug Discovery for Cancer Therapy

(2018) Jin Zhou et al.   Medicinal Chemistry

Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination

(2018) Yuning Liao et al.   ONCOGENE

An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons

(2017) Monica Boselli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP7 small-molecule inhibitors interfere with ubiquitin binding

(2017) Lorna Kategaya et al.   NATURE

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

(2017) Andrew P. Turnbull et al.   NATURE

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

(2017) Gerald Gavory et al.   Nature Chemical Biology

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells

(2017) Jin Zhang et al.   ONCOLOGY RESEARCH

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

(2017) Yuning Liao et al.   Cell Death & Disease

Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma

(2017) Baozhu Zhang et al.   Thoracic Cancer

The role of ubiquitin-specific protease 14 (USP14) in cell adhesion-mediated drug resistance (CAM-DR) of multiple myeloma cells

(2016) Xiaohong Xu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

(2016) Xiangyun Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

(2015) Xin Wang et al.   Chemical Biology & Drug Design

Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis

(2015) Lianxin Zhu et al.   JOURNAL OF MOLECULAR HISTOLOGY

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

(2015) Daichao Xu et al.   eLife

A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor

(2013) Kevin R.W. Ngoei et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of β-Catenin

(2013) Ning Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design Principles of a Universal Protein Degradation Machine

(2012) Mary E. Matyskiela et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases

(2011) Dante Rotili et al.   CHEMISTRY & BIOLOGY

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inactivation of HAUSP in vivo modulates p53 function

(2009) N Kon et al.   ONCOGENE