Editorial Material
Cell & Tissue Engineering
Rachel H. Klein, Paul S. Knoepfler
Summary: Using stem cells as models, Funato et al. and Bressan et al. investigate the functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies highlight the strong regional specificity of oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.
Article
Plant Sciences
Kunpeng Liu, Chunmei Yin, Wenjing Ye, Min Ma, Yuanda Wang, Pan Wang, Yuda Fang
Summary: Reprogramming of chromatin structures and changes in gene expression are crucial for plant male gamete development. Histone variant H3.3 is abundantly expressed in Arabidopsis anthers and plays a key role in male gamete development. H3.3 directly binds and regulates a group of genes involved in reproduction-associated processes, and its function in male gamete development depends on the ASF1A/1B-HIRA pathway.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Oncology
Miaomiao Yu, Yanjie Jia, Zhanchuan Ma, Donglei Ji, Chunyu Wang, Yingying Liang, Qiang Zhang, Huanfa Yi, Lei Zeng
Summary: This study reveals that the PHD finger of ASH1L non-selectively binds to the three methylation states of H3K4, providing insights into its recognition mechanism. Additionally, ASH1L is found to be crucial for the regulation of cell cycle and survival in prostate cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Constance Kleijwegt, Florent Bressac, Coline Seurre, Wilhelm Bouchereau, Camille Cohen, Pascale Texier, Thomas Simonet, Laurent Schaeffer, Patrick Lomonte, Armelle Corpet
Summary: Promyelocytic leukemia nuclear bodies (PML NBs) play a crucial role in genome function by regulating the distribution of HIRA and histone dynamics. Additionally, they regulate the transcription of interferon-stimulated genes (ISGs) and H3.3 deposition mediated by HIRA during inflammatory response.
Review
Oncology
Augusto Faria Andrade, Carol C. L. Chen, Nada Jabado
Summary: Recurrent somatic mutations in histone 3 variants have been found in high-grade gliomas in children and young adults, leading to tumorigenesis by disrupting chromatin states. These oncohistones exhibit neuroanatomical specificity, age distribution, and epigenome landscapes. The unresolved questions regarding their impact on development and interaction with the tumor microenvironment are reviewed, with the understanding that oncohistones mainly thrive and flourish in specific chromatin states during a narrow window of development, presenting vulnerabilities that could be targeted for effective therapies.
Article
Medicine, Research & Experimental
Santiago Haase, Kaushik Banerjee, Anzar A. Mujeeb, Carson S. Hartlage, Fernando M. Nunez, Felipe J. Nunez, Mahmoud S. Alghamri, Padma Kadiyala, Stephen Carney, Marcus N. Barissi, Ayman W. Taher, Emily K. Brumley, Sarah Thompson, Justin T. Dreyer, Caitlin T. Alindogan, Maria B. Garcia-Fabiani, Andrea Comba, Sriram Venneti, Visweswaran Ravikumar, Carl Koschmann, Angel M. Carcaboso, Maria Vinci, Arvind Rao, Jennifer S. Yu, Pedro R. Lowenstein, Maria G. Castro
Summary: This study explores the mechanisms of the H3.3-G34R/V gene mutation in pediatric high-grade gliomas (pHGGs) and its effects on DNA repair pathways and immune response. Combination therapy involving radiotherapy, DNA damage response inhibitors, and STING agonists was found to be effective in treating pHGGs with G34 mutations, leading to long-term survival and immunological memory.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Peipei Wu, Su-Jiun Lin, Danqi Chen, Chunyuan Jin
Summary: Arsenic exposure is associated with increased cancer risk, and epigenetic mechanisms play a crucial role in arsenic-mediated carcinogenesis. Our study identifies the protein MCM2, a histone chaperone, as a key factor in the disruption of H3.3 deposition caused by the polyadenylation of H3.1 mRNA under conditions of arsenic exposure. Our findings suggest that changes in the interaction between MCM2 and H3.3, due to polyadenylation of H3.1 mRNA, may play a pivotal role in arsenic-induced carcinogenesis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lea R. Z. Cohen, Binyamin Kaffe, Eden Deri, Chen Leibson, Malka Nissim-Rafinia, Moria Maman, Nofar Harpaz, Guy Ron, Efrat Shema, Eran Meshorer
Summary: The H3.3K27M mutation increases binding of H3.3 to promoters and affects cell differentiation. This suggests that the effects of the H3.3K27M mutation on gene expression are independent of PRC2 activity.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Cell Biology
Laura Prendergast, Danny Reinberg
Summary: Recent advances in chromatin and epigenetics research have highlighted the significance of core histones, histone variants, and their post-translational modifications in regulating chromatin structure. The role of linker histone H1, which was previously understudied, has come into focus due to its evolutionary conservation, variability in PTMs, and unique functions across different cell types. Contrary to previous assumptions, histone H1 variants are now recognized for their independent roles in various chromatin-based processes, challenging the traditional view of their function solely in chromatin compaction and transcriptional repression.
GENES & DEVELOPMENT
(2021)
Review
Oncology
Hsiao P. J. Voon, Lee H. Wong
Summary: Pediatric high grade gliomas (HGG) are lethal and untreatable tumors. Recent studies have revealed that mutations in chromatin proteins, particularly H3.3 and its associated chaperone complex (ATRX), are a hallmark feature of pediatric HGGs. This article reviews the current literature on the normal functions of the ATRX/H3.3 complex and how they are disrupted by oncogenic mutations, as well as discusses the potential of targeting chromatin and DNA in clinical trials and pre-clinical models.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Volkan Okur, Zefu Chen, Liesbeth Vossaert, Sandra Peacock, Jill Rosenfeld, Lina Zhao, Haowei Du, Emily Calamaro, Amanda Gerard, Sen Zhao, Jill Kelsay, Ashley Lahr, Chloe Mighton, Hillary M. Porter, Amy Siemon, Josh Silver, Shayna Svihovec, Chin-To Fong, Christina L. Grant, Jordan Lerner-Ellis, Kandamurugu Manickam, Suneeta Madan-Khetarpal, Shawn E. McCandless, Chantal F. Morel, G. Bradley Schaefer, Elizabeth M. Berry-Kravis, Ryan Gates, Natalia Gomez-Ospina, Guixing Qiu, Terry Jianguo Zhang, Zhihong Wu, Linyan Meng, Pengfei Liu, Daryl A. Scott, James R. Lupski, Christine M. Eng, Nan Wu, Bo Yuan
Summary: The histone H3 variant H3.3, encoded by genes H3-3A and H3-3B, plays a role in congenital disorders and can replace canonical isoforms H3.1 and H3.2. Studies have found that H3.3 variants are associated with various disease phenotypes, including global developmental delay, short stature, and visual impairment.
NPJ GENOMIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jeehyun Yoon, Oleg Grinchuk, Roberto Tirado-Magallanes, Zhen Kai Ngian, Emmy Xue Yun Tay, You Heng Chuah, Bernice Woon Li Lee, Jia Feng, Karen Carmelina Crasta, Chin Tong Ong, Touati Benoukraf, Derrick Sek Tong Ong
Summary: The histone variant H2AZ is overexpressed in glioblastomas (GBM) and glioma stem cells (GSCs), promoting their proliferation and tumorigenicity. E2F1 and STAT3 synergistically activate H2AZ gene transcription in GSCs, and an E2F/STAT3 inhibitor combination shows promise in suppressing GSC tumorigenicity in GBM treatment.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Multidisciplinary Sciences
Yu-Ching Teng, Aishwarya Sundaresan, Ryan O'Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
Summary: The study reveals that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sima Khazaei, Carol C. L. Chen, Augusto Faria Andrade, Nisha Kabir, Pariya Azarafshar, Shahir M. Morcos, Josiane Alves Franca, Mariana Lopes, Peder J. Lund, Geoffroy Danieau, Samantha Worme, Lata Adnani, Nadine Nzirorera, Xiao Chen, Gayathri Yogarajah, Caterina Russo, Michele Zeinieh, Cassandra J. Wong, Laura Bryant, Steven Hebert, Bethany Tong, Tianna S. Sihota, Damien Faury, Evan Puligandla, Wajih Jawhar, Veronica Sandy, Mitra Cowan, Emily M. Nakada, Loydie A. Jerome-Majewska, Benjamin Ellezam, Carolina Cavalieri Gomes, Jonas Denecke, Davor Lessel, Marie T. McDonald, Carolyn E. Pizoli, Kathryn Taylor, Benjamin T. Cocanougher, Elizabeth J. Bhoj, Anne-Claude Gingras, Benjamin A. Garcia, Chao Lu, Eric I. Campos, Claudia L. Kleinman, Livia Garzia, Nada Jabado
Summary: Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. In this study, knock-in mice with H3.3G34R/V/W mutations were generated to investigate their impact on brain development. The H3.3G34R mutation led to progressive microcephaly, neurodegeneration, and abnormal accumulation of disease-associated microglia, along with neuronal depletion.
Article
Clinical Neurology
C. A. P. F. Alves, O. Sherbini, F. D'Arco, D. Steel, M. A. Kurian, F. C. Radio, G. B. Ferrero, D. Carli, M. Tartaglia, T. B. Balci, N. N. Powell-Hamilton, S. A. Schrier Vergano, H. Reutter, J. Hoefele, R. Gunthner, E. R. Roeder, R. O. Littlejohn, D. Lessel, S. Luttgen, C. Kentros, K. Anyane-Yeboa, C. B. Catarino, S. Mercimek-Andrews, J. Denecke, M. J. Lyons, T. Klopstock, E. J. Bhoj, L. Bryant, A. Vanderver
Summary: The study investigated brain MR imaging patterns of individuals with H3F3 germline variants and found that imaging phenotypes were related to brain features, including a small posterior fossa, dysgenesis of the corpus callosum, cortical developmental abnormalities, and deformity of lateral ventricles.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Review
Cell Biology
Swaminathan Venkatesh, Jerry L. Workman
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Shrikanth S. Gadad, Parijat Senapati, Sajad Hussain Syed, Roshan Elizabeth Rajan, Jayasha Shandilya, Venkatesh Swaminathan, Snehajyoti Chatterjee, Emanuela Colombo, Stefan Dimitrov, Pier Giuseppe Pelicci, Udaykumar Ranga, Tapas K. Kundu
Editorial Material
Cell Biology
Swaminathan Venkatesh, Jerry L. Workman
Article
Biochemistry & Molecular Biology
Michaela Smolle, Jerry L. Workman, Swaminathan Venkatesh
Article
Cell Biology
Arnob Dutta, Madelaine Gogo, Jeong-Hoon Kim, Michaela Smolle, Swaminathan Venkatesh, Joshua Gilmore, Laurence Florens, Michael P. Washburn, Jerry L. Workman
GENES & DEVELOPMENT
(2014)
Article
Cell Biology
Fu Huang, Ariel Paulson, Arnob Dutta, Swaminathan Venkatesh, Michaela Smolle, Susan M. Abmayr, Jerry L. Workman
GENES & DEVELOPMENT
(2014)
Article
Biochemistry & Molecular Biology
Geetha S. Hewawasam, Mark Mattingly, Swaminathan Venkatesh, Ying Zhang, Laurence Florens, Jerry L. Workman, Jennifer L. Gerton
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemical Research Methods
Joshua M. Gilmore, Mihaela E. Sardiu, Swaminathan Venkatesh, Brent Stutzman, Allison Peak, Chris W. Seidel, Jerry L. Workman, Laurence Florens, Michael P. Washburn
MOLECULAR & CELLULAR PROTEOMICS
(2012)
Article
Multidisciplinary Sciences
Swaminathan Venkatesh, Michaela Smolle, Hua Li, Madelaine M. Gogol, Malika Saint, Shambhu Kumar, Krishnamurthy Natarajan, Jerry L. Workman
Editorial Material
Multidisciplinary Sciences
Swaminathan Venkatesh, Jerry L. Workman
Article
Biochemistry & Molecular Biology
Michaela Smolle, Swaminathan Venkatesh, Madelaine M. Gogol, Hua Li, Ying Zhang, Laurence Florens, Michael P. Washburn, Jerry L. Workman
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2012)
Article
Multidisciplinary Sciences
Benjamin G. Kuryan, Jessica Kim, Nancy Nga H. Tran, Sarah R. Lombardo, Swaminathan Venkatesh, Jerry L. Workman, Michael Carey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Review
Genetics & Heredity
Swaminathan Venkatesh, Jerry L. Workman, Michaela Smolle
EPIGENETICS & CHROMATIN
(2013)
Article
Developmental Biology
Swaminathan Venkatesh, Jerry L. Workman
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
(2013)
