Article
Engineering, Environmental
Haoran Peng, Xinyi Qiu, Mingyue Cheng, Yue Zhao, Lutong Song, Bijun Zhu, Yuyang Li, Chao Liu, Shuangshuang Ren, Leiying Miao
Summary: The study introduces a nano platform targeting the immune microenvironment in osteoporosis that promotes alveolar bone regeneration, showing promising results in both in vitro and in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jung-Mi Oh, Sungkun Chun
Summary: In this study, it was found that Compound-K, an active ingredient in ginseng, inhibits lipid droplet and adipogenesis by downregulating the expression of specific genes and proteins involved in adipocyte differentiation. This compound also exhibits antioxidant properties by decreasing reactive oxygen species production and increasing antioxidant enzymes. The findings suggest that Compound-K exerts its anti-adipogenic effects through the activation of the AMPK signaling pathway and inhibition of the ERK/p38 and AKT signaling pathways.
Article
Biochemistry & Molecular Biology
Sebastien Dilly, Miguel Romero, Stephanie Solier, Olivier Feron, Chantal Dessy, Anny Slama Schwok
Summary: ROS in cancer cells play a crucial role in regulating cell death, stemness maintenance, and metabolic reprogramming, which are associated with resistance to chemo/immunotherapy. This paper introduces new inhibitors of NADPH oxidase (NOX), which is important in the tumor microenvironment. One of the inhibitors, called Nanoshutter-1 (NS1), decreases tumor-promoting M2 macrophages in human blood monocytes. NS1 disrupts the NOX2 complex in the macrophages' membrane and mitochondria, leading to vasodilation of blood vessels and potential reduction of hypoxia. By targeting specific cells, NOX2-specific inhibitors could provide precision therapies.
Article
Biochemistry & Molecular Biology
Rongrong Zhao, Huajun Zhao, Quanjuan Guo, Yongliang Mu, Jian Zhang, Yuhang Su, Qiuju Han
Summary: Edaravone (EDA), a novel free radical scavenger, has been shown to have neurovascular protective effects. This study found that EDA can also inhibit liver injury and fibrosis by suppressing monocyte/macrophage recruitment and IL-1 beta production, thereby reducing liver fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Nanoscience & Nanotechnology
Xiangfei Song, Zhiyuan Zheng, Sixue Ouyang, Huiting Chen, Mingyan Sun, Peiru Lin, Yuying Chen, Yuanyuan You, Wenwen Hao, Jia Tao, Peng Zhao
Summary: Researchers have developed macrophage cell membrane-camouflaged nanoparticles that can effectively treat rheumatoid arthritis with reduced side effects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase
Summary: This study reveals that polyamines produced by intestinal bacteria have beneficial effects on enhancing colonic barrier function and immunity by increasing regulatory macrophage abundance and being taken up by colonic epithelial cells.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Haoyu Yin, Lei Fang, Lifeng Wang, Yu Xia, Jiaqi Tian, Lan Ma, Jing Zhang, Ning Li, Weixiu Li, Sanqiao Yao, Lin Zhang
Summary: Silica is essential for various materials and inhaling silica can lead to pulmonary diseases associated with macrophage pyroptosis. The internalization of silica nanoparticles induces membrane rupture and increased intracellular vacuoles. Silica suppresses cell viability and proliferation. Silica-exposed macrophages generate higher levels of ROS and upregulated expression of NLRP3, ASC, Caspase-1, GSDMD, IL-1 beta, and IL-6. Removal of ROS or NLRP3 suppresses the expression of these proteins. Silica exposure increases the expression of TLR4 and NF-kappa B, which are responsible for silica recognition and pyroptosis priming.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Xinxin Li, Xinyu Wang, Qingfeng Liu, Junjie Yan, Donghui Pan, Lizhen Wang, Yuping Xu, Fang Wang, Yuhang Liu, Xiaotian Li, Min Yang
Summary: The boronate-stabilized polyphenol-poloxamer assembled dexamethasone nanodrug demonstrates the ability to efficiently inhibit ROS and nitric oxide production in macrophages, as well as modulate macrophage polarization. In OA mice treated with this nanodrug, body weight and evaluation scores showed similarities to normal mice with reduced inflammation-associated angiogenesis. The nanodrug also inhibits cartilage degradation, bone erosion, and proinflammatory cytokines, showcasing potential for treating various inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cell Biology
Bohao Liu, Cong Ding, Wenbin Tang, Chen Zhang, Yiying Gu, Zhiqiang Wang, Tingzi Yu, Zhuan Li
Summary: Irinotecan, a chemotherapy drug used for metastatic colorectal cancer treatment, can cause liver damage including steatosis and steatohepatitis. In this study, it was found that irinotecan treatment elevated ALT levels, inflammation, and fat accumulation in the liver, which were associated with macrophage activation. Depletion of macrophages improved irinotecan-induced liver injury and inflammatory response. In vitro experiments showed that irinotecan induced ROS production in hepatocytes and upregulated toll-like receptor (TLRs) expression in macrophages. Supernatant from irinotecan-treated hepatocytes triggered macrophage activation and upregulation of TLRs, which were abolished by N-acetylcysteine (NAC). Co-culture experiments revealed that irinotecan-activated macrophages impaired lipid metabolism and induced hepatocyte apoptosis, which were partially prevented by NAC. Using a liver injury model, the combination of NAC and irinotecan prevented macrophage activation, TLR upregulation, liver injury, and triglyceride accumulation.
Article
Nanoscience & Nanotechnology
Jun Wan, Jie Yang, Wenrui Lei, Zezhou Xiao, Pengyu Zhou, Shaoyi Zheng, Peng Zhu
Summary: This study developed liposome nanoparticles (SE-LNPs) using Simvastatin (SIM) as a model drug, EGCG as an antioxidant, and distearyl phosphatidylcholine (DSPC) as carriers. The nanoparticles showed good therapeutic effects in vitro and in vivo by resisting oxidation, promoting M2 polarization, reducing blood lipids, and improving atherosclerotic lesions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yu-Ling Tsai, Ying Chen, Ying-Chuan Chen, Wen-Chiuan Tsai
Summary: In this study, it was found that KDELC2 stimulated vasculogenic factor expression and induced HUVEC proliferation. The activation of NLRP3 inflammasome and autophagy was confirmed through HIF-1alpha and mitochondrial ROS production. Inhibiting NLRP3 inflammasome and autophagy reduced endothelial overgrowth.
Article
Fisheries
Xuangang Wang, Xiangfu Kong, Hengshun Li, Ying Chen, Ze Tao, Fan Zhang, Zhixiang Duan, Zhentao Chen, Jinxiang Liu, Quanqi Zhang, Haiyang Yu
Summary: This study revealed that Edwardsiella piscicida invasion caused pyroptosis in head kidney macrophages (HKMs) of black rockfish (Sebastes schlegelii), and identified key genes and pathways associated with pyroptosis.
Article
Engineering, Environmental
Kai Yin, Dongxu Wang, Yue Zhang, Hongmin Lu, Lulu Hou, Tiantian Guo, Hongjing Zhao, Mingwei Xing
Summary: Microplastics, a new and increasing environmental pollutant, induce liver inflammation and the formation of macrophage extracellular traps (METs). Macrophages actively phagocytose microplastics, leading to elevated ROS levels, disruption of mitochondrial homeostasis, activation of mitochondrial autophagy and lysosomes, and eventually lysosome rupture and release of calcium ions to induce METs formation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Cell Biology
Canling Long, Rui Guo, Ruijuan Han, Kang Li, Yanbing Wan, Jiqing Xu, Xiaoyu Gong, Yanqiu Zhao, Xinhuang Yao, Jia Liu
Summary: The study found that M1- or M2-polarized macrophages play critical roles in the proliferation, cardiac differentiation, and maturation of iPSCs.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Immunology
Anthony J. Covarrubias, H. Ibrahim Aksoylar, Tiffany Horng
SEMINARS IN IMMUNOLOGY
(2015)
Article
Biology
Anthony J. Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W. Snyder, Andrew J. Worth, Shankar S. Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C. Espinosa, Dudley Lamming, Brendan D. Manning, Yijing Zhang, Ian A. Blair, Tiffany Horng
Article
Oncology
Arnold I. Chin, Andrea K. Miyahira, Anthony Covarrubias, Juli Teague, Beichu Guo, Paul W. Dempsey, Genhong Cheng
Editorial Material
Cell Biology
Anthony J. Covarrubias, Tiffany Horng
Meeting Abstract
Urology & Nephrology
Arnold I. Chin, Andrea Miyahara, Anthony Covarrubias, Paul W. Dempsey, Genhong Cheng
JOURNAL OF UROLOGY
(2009)
Meeting Abstract
Urology & Nephrology
Arnold Chin, Andrea Miyahara, Anthony Covarrubias, Juli Teague, Paul Dempsey, Genhong Cheng
JOURNAL OF UROLOGY
(2010)
Article
Multidisciplinary Sciences
Vanessa Byles, Anthony J. Covarrubias, Issam Ben-Sahra, Dudley W. Lamming, David M. Sabatini, Brendan D. Manning, Tiffany Horng
NATURE COMMUNICATIONS
(2013)
Review
Cell Biology
Anthony J. Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin
Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Correction
Endocrinology & Metabolism
Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, Indra Heckenbach, Ryan Kwok, Christopher D. Wiley, Hoi-Shan Wong, Eddy Gibbs, Shankar S. Iyer, Nathan Basisty, Qiuxia Wu, Ik-Jung Kim, Elena Silva, Kaitlyn Vitangcol, Kyong-Oh Shin, Yong-Moon Lee, Rebeccah Riley, Issam Ben-Sahra, Melanie Ott, Birgit Schilling, Morten Scheibye-Knudsen, Katsuhiko Ishihara, Stephen R. Quake, John Newman, Charles Brenner, Judith Campisi, Eric Verdin
Summary: A correction to this paper has been published and can be accessed via a link at the top of the paper.
Article
Endocrinology & Metabolism
Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, Indra Heckenbach, Ryan Kwok, Christopher D. Wiley, Hoi-Shan Wong, Eddy Gibbs, Shankar S. Iyer, Nathan Basisty, Qiuxia Wu, Ik-Jung Kim, Elena Silva, Kaitlyn Vitangcol, Kyong-Oh Shin, Yong-Moon Lee, Rebeccah Riley, Issam Ben-Sahra, Melanie Ott, Birgit Schilling, Morten Scheibye-Knudsen, Katsuhiko Ishihara, Stephen R. Quake, John Newman, Charles Brenner, Judith Campisi, Eric Verdin
Article
Cell Biology
John C. Newman, Anthony J. Covarrubias, Minghao Zhao, Xinxing Yu, Philip Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, Eric Verdin
