Review
Biochemistry & Molecular Biology
Alessandra Puddu, Fabrizio Montecucco, Davide Maggi
Summary: Caveolae are cell surface plasma membrane invaginations observed in terminally differentiated cells, characterized by the presence of caveolin-1. They play a central role in regulating atherosclerosis and can have both pro-atherogenic and anti-atherogenic functions depending on the cell type examined. This study focuses on the role of caveolin-1 in regulating the fate of LDLs in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Juan Du, Yahui Liu, Gelei Lan, Yao Zhou, Yingmeng Ni, Kai Liao, Fang Zheng, Qijian Cheng, Guochao Shi, Xiao Su
Summary: Polymerase 1 and transcript release factor (PTRF) regulates the release of interleukin 33 (IL-33), which is involved in asthma development. Z-DNA binding protein 1 (ZBP1) induces necroptosis, causing inflammatory diseases. This study investigated whether PTRF, IL-33, and ZBP1 mediate house dust mite (HDM)-induced macrophage necroptosis and airway inflammation in an asthma mouse model. The findings suggest that the PTRF-IL-33-ZBP1 signaling pathway could be a potential target for reducing airway inflammation.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Sadia Afrin, Malak El Sabeh, Mariko Miyashita-Ishiwata, Natasha Charewycz, Bhuchitra Singh, Mostafa A. Borahay
Summary: Simvastatin alters the caveolae and CAV1 in human leiomyomas, influencing ER-alpha signaling and plasma membrane trafficking, providing new insights for the treatment of uterine leiomyomas.
Article
Chemistry, Multidisciplinary
Dariusz Lachowski, Carlos Matellan, Sahana Gopal, Ernesto Cortes, Benjamin K. Robinson, Alberto Saiani, Aline F. Miller, Molly M. Stevens, Armando E. del Rio Hernandez
Summary: Liver fibrosis is a common manifestation of chronic liver injury, and hepatic stellate cells (HSCs) play a crucial role in this process. This study reveals a mechanism by which matrix stiffness regulates plasma membrane tension, leading to increased secretion of TIMP-1. The expression of TIMP-1 and caveolin-1 is also found to be increased in cirrhosis and hepatocellular carcinoma.
Review
Endocrinology & Metabolism
Xiangnan Chen, Lihua Zhu, Linlin Chen, Fenghua Zhang, Hui Wang, Yanjun Yang, Wenfeng Ye
Summary: This narrative review investigates the expression of caveolin-1 (cav1) in normal and pathological pregnancy. The review shows differences in cav1 expression between normal and pathological pregnancy, suggesting that cav1 may be a potential susceptibility gene for pathological pregnancy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Neurosciences
Demao Cao, Bing Li, Cheng Cao, Juyi Zhang, Xiang Li, Haiying Li, Zhengquan Yu, Haitao Shen, Ming Ye
Summary: In this study, the researchers investigated the role and molecular mechanism of Caveolin-1 (CAV1) in brain injury using a rat autologous whole blood injection model and an in vitro model of intracerebral hemorrhage (ICH). The results showed that CAV1 overexpression worsened neurological dysfunction and cellular apoptosis in ICH rats, while CAV1 knockdown ameliorated these effects. Additionally, CAV1 overexpression aggravated neuroinflammation, while CAV1 knockdown inhibited microglia activation and neuroinflammatory response. The in vitro experiments also revealed the involvement of CAV1 in regulating the C-Src, IKK-beta, and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Weike Liu, Huajing Song, Jing Xu, Yuqi Guo, Chunju Zhang, Yanli Yao, Hua Zhang, Zhendong Liu, Yue-Chun Li
Summary: This study investigates the mechanism underlying the inhibition of endothelial mitophagy by low blood flow shear stress (SS) through the Cav-1/miR-7-5p/SQSTM1 signaling pathway. The results show that low SS suppresses endothelial mitophagy, leading to impaired mitochondrial homeostasis and endothelial dysfunction.
Review
Biology
Cody M. Dalton, Camille Schlegel, Catherine J. Hunter
Summary: Cav1 is a protein present in various forms and locations in cells and tissues. Understanding its structure and function can provide insights into cell growth, death, and cellular processes. Cav1 is involved in multiple cellular compartments and plays a role in cytoskeletal interactions, endocytosis, and cholesterol trafficking. Its involvement in stem cells, proliferation, cell death, and tumor growth is of particular interest.
Article
Biochemistry & Molecular Biology
Anil Kumar Bommanaboina, Shazia Jamal, Neesar Ahmed
Summary: Taxol is a widely used natural antitumor drug, but resistance to it is still a significant issue. In this study, the recruitment and formation of Cav-1-GFP clusters on cell membranes were observed, as well as the formation of Caveolae after treatment. Molecular docking results indicate a favorable interaction between taxol and Cav-1. Further research on the molecular mechanism of taxol uptake through Caveolae/Cav-1 may help determine if Cav-1 can be used to increase taxol uptake and sensitize drug-resistant cancer cells.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shivani Gokani, Lokesh Kumar Bhatt
Summary: Caveolin-1 is a key protein localized in caveolae of the plasma membrane of eukaryotic cells, involved in regulating cellular signaling and various disease processes. Its role in neurodegeneration, cognitive decline, aging, and tumorigenesis has been studied, although the exact mechanisms are still unclear.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Angel Cayo, Whitney Venturini, Danitza Rebolledo-Mira, Rodrigo Moore-Carrasco, Andres A. Herrada, Estefania Nova-Lamperti, Claudio Valenzuela, Nelson E. Brown
Summary: Senescent cells have the ability to synthesize and secrete bioactive molecules, known as the SASP, and often upregulate autophagy to improve cell viability. However, the effects of mTORC1 inhibition, with or without autophagy inhibition, on senescence and the SASP induced by Palbociclib are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Yuyang Wang, Yangyang Zhang, Wei Zuo, Zongyi Bo, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu
Summary: In this study, it was demonstrated that the sigma B protein of ARV interacts with Cav-1 during lipid raft-mediated endocytosis, highlighting the significance of Cav-1 in ARV entry.
Article
Dentistry, Oral Surgery & Medicine
Shuang Lei, Jian Li, Jingjun Yu, Fulong Li, Yaping Pan, Xu Chen, Chunliang Ma, Weidong Zhao, Xiaolin Tang
Summary: Bacteremia induced by periodontal infection plays a significant role in the threat of general health. P. gingivalis DNA/virulence factors are found in the brain tissues of Alzheimer's disease patients. The impact of P. gingivalis bacteremia on blood-brain barrier permeability and its underlying mechanism are still uncertain.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Natasha Buwa, Nivedhika Kannan, Shaunak Kanade, Nagaraj Balasubramanian
Summary: Cell-matrix adhesion regulates Cav1 phosphorylation through FAK at focal adhesions, with FAK more prominently modulating pY14Cav1 levels at higher stiffness.
Article
Cell Biology
Andreas Goutas, Zozo Outskouni, Ioanna Papathanasiou, Maria Satra, George Koliakos, Varvara Trachana
Summary: Research shows that oxidative stress can lead to upregulation, phosphorylation, and nuclear translocation of Cav-1 in young stem cells, but this regulation is lost as cells age. Older cells are unable to repair DNA damage, and downregulation of Cav-1 results in persistent DNA damage and onset of senescence. Additionally, the establishment of senescence is mediated by autophagy activation.