Article
Immunology
Jingyu Ma, Miaomiao Han, Di Yang, Tingting Zheng, Ran Hu, Bin Wang, Youqiong Ye, Junling Liu, Gonghua Huang
Summary: This study shows that the absence of Vps33B in DCs exacerbates Th2-mediated allergic lung inflammation, revealing the regulatory role of cross-talk between DCs and CD4(+) T cells in the pathogenesis of allergic asthma.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Chen Dong
Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Pablo de Lucia Finkel, Wenjing Xia, Wilfred A. Jefferies
Summary: ILC2s are a type of innate immune cells that play a role in expelling parasites and inducing allergic inflammation. Their unique properties and functions have been the subject of increasing research interest and have led to discoveries that were previously considered unthinkable.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Jing Zhang, Yuan Zou, Longmin Chen, Qianqian Xu, Yi Wang, Min Xie, Xiansheng Liu, Jianping Zhao, Cong-Yi Wang
Summary: Asthma is a multifactorial disorder characterized by chronic inflammation, hyper-responsiveness, remodeling, and reversible obstruction. Recent studies suggest that most cases are Th2-high type and regulatory T cells (Tregs) play an essential role in limiting the development of allergic diseases. Researchers are exploring new treatment methods based on Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xinxing Zhang, Yu Ma, Yanyu He, Wenjing Gu, Yongdong Yan, Wei Ji, Li Huang, Yuqing Wang, Chuangli Hao, Gang Li, Zhengrong Chen
Summary: The overexpression of Foxp2 gene can attenuate allergic asthma by inhibiting Th9 cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Fisheries
Hongfei Tian, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: Cytokines are small molecular proteins secreted by immune cells to regulate cell growth, differentiation, and effects. T cells have been identified in fish and shown to be involved in the immune response. However, research on fish T cell identification and differentiation is still in its early stages and requires more effort.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Hongfei Tian, Jing Xing, Xiaoqian Tang, Heng Chi, Xiuzhen Sheng, Wenbin Zhan
Summary: The T-bet transcription factor in flounder plays a key role in immune responses, with abundant expression in specific organs and significant upregulation after infection. T-bet(+) cells were identified in lymphocytes and B cells, and found to proliferate in response to specific cytokines. These results suggest that T-bet may act as a master regulator of Th1-type immune responses in flounder CD4(+) T lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Amania A. Sheikh, Joanna R. Groom
Summary: During viral infection, CD4(+) T cells differentiate into Th1 cells for inflammation and pathogen clearance, or Tfh cells for enhancing germinal center reactions. The lineage-defining transcription factors T-bet and Bcl6 play key roles in determining the fate of CD4(+) T cells toward Th1 or Tfh. Transcriptional networks guided by cytokine cues dynamically shape the fate and function of these cells during infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Rama K. Gurram, Danping Wei, Qiao Yu, Matthew J. Butcher, Xi Chen, Kairong Cui, Gangqing Hu, Mingzhu Zheng, Xiaoliang Zhu, Jangsuk Oh, Bing Sun, Joseph F. Urban Jr, Keji Zhao, Warren J. Leonard, Jinfang Zhu
Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) play a protective role in helminth infection and allergies, but their importance and interaction in type 2 immune responses are still debated.
Article
Chemistry, Medicinal
Bo-Jeong Pyun, Joo Young Lee, Yu Jin Kim, Kon-Young Ji, Dong Ho Jung, Ki-Sun Park, Kyuhyung Jo, Susanna Choi, Myung-A Jung, Yun Hee Kim, Taesoo Kim
Summary: The study investigated the effects of Gardenia jasminoides extracts on allergic rhinitis-related inflammatory responses, finding that the extracts improved clinical symptoms and reduced Th2 cytokine secretion in a mouse model. Additionally, treatment with the extracts decreased inflammatory markers in primary human nasal epithelial cells. The results suggest that Gardenia jasminoides extracts may serve as therapeutic agents for allergic rhinitis by modulating the Th2 inflammatory response.
Article
Cell Biology
Qiao Wang, Linlin Guo, Ziling Zeng, Yueru Huang, Hongmei Tang, Hang Hu, Xiefang Yuan, Jun Deng, Gang Qin, Xing Wang, Yun Zhang
Summary: This study found that NEF can protect the body from allergic inflammation induced by HDM by inhibiting the NF-kappa B signaling of DCs and regulating the expression of cytokines.
Article
Biology
Margaret H. O'Connor, Roshell Muir, Marita Chakhtoura, Michael Fang, Eirini Moysi, Susan Moir, Alison J. Carey, Alyssa Terk, Carmen N. Nichols, Talibah Metcalf, Constantinos Petrovas, Mark J. Cameron, Virginie Tardif, Elias K. Haddad
Summary: Researchers report a new population of Innate Lymphoid Cells in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection, resulting in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Justine Segaud, Wenjin Yao, Pierre Marschall, Francois Daubeuf, Christine Lehalle, Beatriz German, Pierre Meyer, Pierre Hener, Cecile Hugel, Eric Flatter, Marine Guivarch, Laetitia Clauss, Stefan F. Martin, Mustapha Oulad-Abdelghani, Mei Li
Summary: Allergic sensitisation in the skin can lead to allergic dermatitis and further to airway asthma. This study examines the difference between superficial or deep skin sensitisation, characterises the immune cells generated, and shows differential TSLP and IL-1 beta involvement.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Summary: During intracellular infection, T follicular helper (T-FH) and T helper 1 (T(H)1) cells have different roles in promoting immune responses. This study identifies Aiolos as a crucial regulator of T-FH and CD4-CTL programming. Aiolos deficiency leads to reduced T-FH differentiation and antibody production, while increasing CD4-CTL programming and cytolytic molecule expression.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajana, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Summary: Gram-positive bacterial infections can cause organ failure and death in sepsis. Bacillus anthracis PGN, a component shed during bacterial replication, can promote sepsis-like pathology. This study found that purified Bacillus anthracis PGN can activate human dendritic cells (DCs), promote the production of proinflammatory cytokines, and induce the differentiation of T(H)17 cells.
Article
Infectious Diseases
Gui-Ling Chen, Xiao-Feng Li, Xia-Hong Dai, Nan Li, Meng-Li Cheng, Zhen Huang, Jian Shen, Yu-Hua Ge, Zhen-Wei Shen, Yong-Qiang Deng, Shu-Yuan Yang, Hui Zhao, Na-Na Zhang, Yi-Fei Zhang, Ling Wei, Kai-Qi Wu, Meng-Fei Zhu, Cong-Gao Peng, Qi Jiang, Shou-Chun Cao, Yu-Hua Li, Dan-Hua Zhao, Xiao-Hong Wu, Ling Ni, Hua-Hao Shen, Chen Dong, Bo Ying, Guo-Ping Sheng, Cheng-Feng Qin, Hai-Nv Gao, Lan-Juan Li
Summary: This study evaluated the preliminary safety, tolerability, and immunogenicity of an mRNA vaccine (ARCoV) encoding the receptor-binding domain of the SARS-CoV-2 spike protein. The results showed that ARCoV was safe and well-tolerated at all doses and induced strong humoral and cellular immune responses. These findings support further clinical testing of ARCoV on a large scale.
Editorial Material
Medicine, General & Internal
Xin Wu, Huji Xu, Chen Dong
CHINESE MEDICAL JOURNAL
(2022)
Article
Biology
Han Feng, Xiaohong Zhao, Jenny Xie, Xue Bai, Weiwei Fu, Hairong Chen, Hong Tang, Xiaohu Wang, Chen Dong
Summary: This study systematically compared the transcriptomic profiles of Tfh cells from different types of immune responses and found differential induction of gene clusters corresponding to effector Th cells. It also discovered a subset of Tfh cells producing IFN-gamma in influenza virus infection, which had a unique developmental regulation. Selective ablation of these cells impaired immune response and control of infection.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Editorial Material
Biology
Xinyi Guo, Chen Dong
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Cell Biology
Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Dandan Wu, Dianna Spilca, Que Le, Xin Yang, Katelyn Alvarez, William Curtis Hines, Xuexian O. Yang, Meilian Liu
Summary: The lack of COX-2 in adipocytes promotes white adipose tissue development and increases the size and number of adipocytes, leading to obesity and insulin resistance. Treatment with PGE2 can reverse the increased size and number of adipocytes caused by COX-2 knockout.
Article
Oncology
Shanjuan Hong, Qing Yuan, Haizhui Xia, Yuan Dou, Tiantian Sun, Tian Xie, Zhiyin Zhang, Wei He, Chen Dong, Jian Lu, Li Guo, Ling Ni
Summary: This study established an ex vivo cultured tumor tissue model to evaluate the efficacy of a VISTA inhibitor in treating clear cell renal cell carcinoma (ccRCC). The results showed that all tested patients responded to the anti-VISTA antibody, while only a small fraction responded to the anti-PD-1 antibody. Co-blockade of VISTA and PD-1 had a synergistic effect in 20% of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Xin Yang, Xiaofeng Ding, Lu Wang, Huyen Le, Lily Elizabeth R. Feldman, Xuebo Men, Cen Yan, Wendong Huang, Yingmei Feng, Feng Liu, Xuexian O. Yang, Meilian Liu
Summary: The intermittent fasting (IF) diet has been found to have significant benefits for diabetes prevention, but the specific mechanisms underlying its effects are not well understood. This study shows that COX-2 expression is suppressed in the white adipose tissue (WAT) of obese humans and is upregulated in the WAT of obese mice when subjected to IF. Depletion of COX-2 in adipocytes leads to a decrease in the fractions of Tregs and a decrease in the frequency of macrophages in WAT, along with an increase in the abundance of gamma delta T cells. Adipocyte-derived PGE2 promotes Treg proliferation and is essential for the immune and metabolic benefits of IF.
Article
Multidisciplinary Sciences
Xinwei Liu, Jing Hao, Peng Wei, Xiaohong Zhao, Qiuyan Lan, Lu Ni, Yongzhen Chen, Xue Bai, Ling Ni, Chen Dong
Summary: In this study, the researchers found that SMAD4 plays a critical role in promoting CD8(+) T cell function in both tumor and infection models. SMAD4-mediated transcriptional regulation enhances CD8(+) T cell activation and cytotoxicity through the T cell receptor (TCR) signaling pathway. Furthermore, SMAD4 is directly phosphorylated by ERK following TCR activation.
Review
Allergy
Han Feng, Zixuan Zhao, Chen Dong
Summary: This article reviews the plasticity of T-FH cells in various types of immune responses and highlights their important implications in understanding and treating human diseases, particularly allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinxin Chi, Wei Jin, Xiaohong Zhao, Tian Xie, Jing Shao, Xue Bai, Yu Jiang, Xiaohu Wang, Chen Dong
Summary: This study reveals the dual crucial functions of RORγt in effector T(H)17 cells, maintaining the T(H)17 cell program and constraining the conversion to T(H)2 cells. The loss of RORγt leads to closed chromatin configuration and inhibits Il4 transcription. These findings provide previously unidentified considerations in therapeutic targeting of RORγt.
Article
Immunology
Qinli Sun, Xiaohong Zhao, Ruifeng Li, Dingfeng Liu, Birui Pan, Bowen Xie, Xinxin Chi, Dongli Cai, Peng Wei, Wei Xu, Kun Wei, Zixuan Zhao, Yujie Fu, Ling Ni, Chen Dong
Summary: Sun et al. discovered that STAT3, activated by IL-10 and IL-21, plays crucial roles in the terminal differentiation of effector CD8(+) T cells in cancer and acute infection. STAT3 enhances effector functions and survival of T-ex(term) cells in the tumor microenvironment, leading to improved tumor control. It transcriptionally promotes effector function-related genes and collaborates with BATF and IRF4 to mediate chromatin activation at effector gene loci.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Yuling Li, Jing Ge, Xiaohong Zhao, Miao Xu, Mengting Gou, Bowen Xie, Jinling Huang, Qinli Sun, Lin Sun, Xue Bai, Sangnee Tan, Xiaohu Wang, Chen Dong
Summary: Yuling Li et al. found that BCL6 is selectively expressed in CCR6(+) ILC3 among the ILC family. BCL6 expression, induced by intestinal microbiota, restrains the effector function and plasticity of CCR6(+) ILC3.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Parasitology
Zhen-Rong Ma, Zhuo-Lin Li, Ni Zhang, Bin Lu, Xuan-Wu Li, Ye-Hong Huang, Dibo Nouhoum, Xian-Shu Liu, Ke-Chun Xiao, Li-Ting Cai, Shao-Rui Xu, Xue-Xian O. Yang, Shuai-Qin Huang, Xiang Wu
Summary: This study found that intervention with Trichinella spiralis could alleviate the severity of ulcerative colitis by inhibiting GSDMD-mediated pyroptosis. This provides new insight into the mechanistic study and application of helminths in treating colitis.
PARASITES & VECTORS
(2023)
Letter
Environmental Sciences
Zhen Rong Ma, Xi Sun, Wen Xiao Zheng, Xuan Wu Li, Ni Zhang, Ye Hong Huang, Bin Lu, Zhuo Lin Li, Di Bo Nouhoum, Xin Ling Yu, Jie Zhou, Hong Zhi Chen, Xue Xian Yang, Xiang Wu
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, LuLin Jiang, Tiantian Guo, Mingyu Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fanwei Zeng, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhiping Zeng, Timothy Y. Huang, Chen Dong, Hong Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Weihon Song, Xin Wang
Summary: Down syndrome is one of the critical risk factors for early-onset Alzheimer's disease, and the DS-related gene USP25 has been identified as a critical regulator of AD pathology, potentially serving as a pharmacological target for AD drug development.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
