Narciclasine induces autophagy-dependent apoptosis in triple-negative breast cancer cells by regulating the AMPK-ULK1 axis

Design, synthesis, and biological evaluation of polo-like kinase 1/eukaryotic elongation factor 2 kinase (PLK1/EEF2K) dual inhibitors for regulating breast cancer cells apoptosis and autophagy

(2018) Zhaoping Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and structure-activity relationship studies of a focused library of pyrimidine moiety with anti-proliferative and anti-metastasis activities in triple negative breast cancer

(2017) Dahong Yao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas

(2017) Nadia Bouhamdani et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer

(2017) Liang Ouyang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor angiogenesis revisited: Regulators and clinical implications

(2017) Roberto Ronca et al.   MEDICINAL RESEARCH REVIEWS

Extracellular vesicles in the tumor microenvironment: Therapeutic resistance, clinical biomarkers, and targeting strategies

(2017) L. Han et al.   MEDICINAL RESEARCH REVIEWS

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

New and revisited approaches to preserving the reperfused myocardium

(2017) Robert A. Kloner et al.   Nature Reviews Cardiology

Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer

(2017) Jian Gao et al.   Cell Death & Disease

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

(2017) Sofi G. Julien et al.   PLOS BIOLOGY

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

High-throughput «Omics» technologies: New tools for the study of triple-negative breast cancer

(2016) Gaëlle Judes et al.   CANCER LETTERS

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair

(2016) Diana H. Liang et al.   CANCER LETTERS

Mitotic catastrophe and cancer drug resistance: A link that must to be broken

(2016) Tatiana V. Denisenko et al.   DRUG RESISTANCE UPDATES

Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer

(2016) V. K. Kozyreva et al.   MOLECULAR CANCER THERAPEUTICS

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

(2016) Shengzheng Wang et al.   ORGANIC LETTERS

Narciclasine – an Amaryllidaceae Alkaloid with Potent Antitumor and Anti-Inflammatory Properties

(2016) Robert Fürst   PLANTA MEDICA

SARTools: A DESeq2- and EdgeR-Based R Pipeline for Comprehensive Differential Analysis of RNA-Seq Data

(2016) Hugo Varet et al.   PLoS One

Breast cancer statistics, 2015: Convergence of incidence rates between black and white women

(2015) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

(2015) Rui Zhou et al.   CHEMICAL COMMUNICATIONS

Haemanthus coccineusextract and its main bioactive component narciclasine display profound anti-inflammatory activitiesin vitroandin vivo

(2015) Simone Fuchs et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells

(2014) Chuan-Ming Xie et al.   Autophagy

Plant lectins, from ancient sugar-binding proteins to emerging anti-cancer drugs in apoptosis and autophagy

(2014) Q.-L. Jiang et al.   CELL PROLIFERATION

Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness

(2012) K. L. Cook et al.   CANCER RESEARCH

Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTP-ase Targeting Agents against Brain Cancers

(2012) Gwendoline Van Goietsenoven et al.   MEDICINAL RESEARCH REVIEWS

Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

(2010) Gwendoline Van Goietsenoven et al.   FASEB JOURNAL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Chemistry, Biology, and Medicinal Potential of Narciclasine and its Congeners

(2008) Alexander Kornienko et al.   CHEMICAL REVIEWS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH