Article
Gastroenterology & Hepatology
Xiaolin Wang, Yong He, Bryan Mackowiak, Bin Gao
Summary: MicroRNAs are small, non-coding RNAs that play crucial roles in regulating liver functions and are associated with various liver diseases, making them promising for early diagnosis and treatment strategies. Continued research on miRNAs in the liver may lead to the identification of biomarkers and therapeutic targets for liver diseases in the future.
Review
Cell Biology
Bridget Martinez, Philip Peplow
Summary: Glaucoma is a neurodegenerative disease with unknown pathogenesis but increased intraocular pressure as a major risk factor. MicroRNAs play important roles in the development of primary open-angle glaucoma. Lowering intraocular pressure is the only available treatment, and further studies are needed to identify validated biomarkers and explore therapeutic interventions.
NEURAL REGENERATION RESEARCH
(2022)
Review
Medicine, General & Internal
Xiangyu Chu, Dan Wei, Xinxin Liu, Di Long, Xiaodong Tian, Yinmo Yang
Summary: Pancreatic cancer is a highly aggressive malignancy with a poor prognosis. Aberrant expression of microRNAs (miRNAs) is often associated with the initiation, progression, and metastasis of pancreatic cancer. This review discusses the potential of integrating miRNAs into the treatment of pancreatic cancer and offers insights for the development of precision medicine.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Brian G. Jorgensen, Seungil Ro
Summary: This article reviews the current literature on miRNAs associated with colorectal cancer (CRC) and their potential use as biomarkers for the diagnosis of gastrointestinal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Liuying Chen, Yizhou Xu
Summary: Doxorubicin-induced cardiomyopathy (DIC) is a cumulative dose-dependent cardiac toxicity disease, where miRNAs may participate in the pathological process by inducing oxidative stress and apoptosis. Research on the roles of miRNAs in DIC could lead to the discovery of diagnostic biomarkers and potential therapeutic targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, Research & Experimental
Sen Liu, Min Fan, Qiang Zheng, Shengwei Hao, Longjun Yang, Qingrong Xia, Congcong Qi, Jinfang Ge
Summary: Alzheimer's disease is a common neurodegenerative disease affecting millions worldwide. Recent studies have shown differential abundance and varieties of miRNAs in central and peripheral tissues of AD patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Nadine de Godoy Torso, Joao Kleber Novais Pereira, Marilia Berlofa Visacri, Pedro Eduardo Nascimento Silva Vasconcelos, Pia Loren, Kathleen Saavedra, Nicolas Saavedra, Luis A. Salazar, Patricia Moriel
Summary: This systematic review summarizes scientific evidence on dysregulated miRNAs as potential biomarkers or therapeutic targets for cisplatin nephrotoxicity, with a focus on miR-34a and miR-21. In silico analysis revealed validated targets for these miRNAs, but studies in humans are limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Karine Jacquet, Olivier Binda
Summary: The INhibitor of Growth (ING) family of proteins was originally identified in 1996 with ING1 as a tumor suppressor. However, subsequent research has shown that most ING family members play a key role in cellular proliferation and may not all function as tumor suppressors. Some ING family members have been found to correlate with poor prognosis in certain cancers.
Review
Cell Biology
Changhai Tian, Jessica N. Ziegler, Irving H. Zucker
Summary: Extracellular vesicles (EVs) are important in cardiovascular diseases (CVDs), particularly in heart failure, where they transfer bioactive substances. miRNAs in EVs play a role in the progression of heart failure and their sorting is tightly controlled. Extracellular miRNAs, especially circulating EV-miRNAs, show promise as biomarkers and therapeutic targets for heart failure. This review summarizes the latest progress in understanding the role of EV-miRNAs in heart failure and their potential in therapeutic strategies.
Review
Microbiology
Muneyoshi Kimura, Sagar Kothari, Wajiha Gohir, Jose F. Camargo, Shahid Husain
Summary: MicroRNAs (miRNAs) play a crucial role in post-transcriptional gene expression regulation, disease pathogenesis, and immune response. They are explored as diagnostic biomarkers and therapeutic targets in clinical settings.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Colorectal cancer is one of the most common and lethal malignant tumors in the world. MicroRNAs have been identified as key regulators in CRC and potential targets to overcome drug resistance.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Kahlilia C. Morris-Blanco, Anil K. Chokkalla, Vijay Arruri, Soomin Jeong, Samantha M. Probelsky, Raghu Vemuganti
Summary: Epigenetic modifications play a central role in the progression of stroke pathology, regulating gene expression, cellular injury response, and functional outcomes after stroke. Technological advances in epigenetics may provide innovative targets and promising therapeutic approaches for stroke treatment.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Medicine, Research & Experimental
Bernhard Laggerbauer, Stefan Engelhardt
Summary: The discovery of microRNAs and their role in cardiovascular diseases has sparked interest in using microRNAs as drug targets. MicroRNA-based drugs have made significant progress in preclinical and clinical testing for cardiovascular diseases, showing great potential in treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biology
Lunkun Ma, Ankit Gilani, Qian Yi, Liling Tang
Summary: Thermogenesis plays a significant role in combating metabolic disorders and obesity, and microRNAs are involved in regulating adipose thermogenesis. This review discusses the diverse roles of microRNAs in adipose thermogenesis and their potential as a target for obesity treatment. Recommendations for future research and miRNA-based therapies for obesity are highlighted.
Review
Oncology
Chia-Jung Li, Yen-Dun Tony Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, Pei-Yi Chu
Summary: Breast cancer emergencies have rapidly evolved in medicine over the past decade, with targeted therapy emerging as a new important treatment modality that offers advantages over traditional surgery, radiotherapy, and chemotherapy.