Article
Biochemistry & Molecular Biology
Alessia Salzillo, Angela Ragone, Annamaria Spina, Silvio Naviglio, Luigi Sapio
Summary: This study investigated the synergistic effects of chlorogenic acid (CGA) and doxorubicin (Doxo) in osteosarcoma cells. The results showed that CGA enhanced the therapeutic effect of Doxo, increased cell death rate, and had a protective effect on heart cells. The study also found that the p44/42 MAPK pathway may play an important role in CGA increasing susceptibility to Doxo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andrea Di Credico, Giulia Gaggi, Pascal Izzicupo, Ines Bucci, Angela Di Baldassarre
Summary: Nutraceuticals and functional foods, such as resveratrol, play a significant role in enhancing immune surveillance in menopausal women through increasing cytotoxic activity of lymphocytes. The study analyzed the effects of resveratrol on lymphocyte cytotoxicity in menopausal women, revealing increased cytokine production, immune synapse formation, and target cell lysis with resveratrol treatment, without affecting total antioxidant capacity of lymphocytes.
Article
Biology
Teng Xue, Shujia Fei, Jian Gu, Nan Li, Pengxue Zhang, Xiaoqiu Liu, Paul R. Thompson, Xuesen Zhang
Summary: Inhibiting the activity of PADIs combined with Doc has an additive inhibitory effect on tumor cell growth and helps prevent the maintenance of cancer cell stemness.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Angela De Luca, Daniele Bellavia, Lavinia Raimondi, Valeria Carina, Viviana Costa, Milena Fini, Gianluca Giavaresi
Summary: Resveratrol (RSV) exhibits multiple tumor-suppressing activities on osteosarcoma (OS) cell lines, including inhibition of cell growth, promotion of cell differentiation, inhibition of cell migration, and enhancement of cytotoxic effect in combination with chemotherapy.
Article
Medicine, Research & Experimental
M. V. M. Novais, E. R. Gomes, M. C. Miranda, J. O. Silva, D. A. Gomes, F. C. Braga, R. M. Padua, M. C. Oliveira
Summary: Cancer is a major global public health problem, with current chemotherapy drug DOX limited by cardiotoxicity. To address this issue, research has developed drug-loaded liposomes to enhance the therapeutic effect in cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Bharat Pateliya, Vinod Burade, Sunita Goswami
Summary: The concomitant use of naringenin and metformin with doxorubicin chemotherapy showed increased cytotoxicity in TNBC cells in vitro and reduced tumor volume and weight in vivo, enhancing antitumor activity. Biopsies demonstrated increased necrosis and inhibited cell proliferation. No adverse effects were observed in organs, blood glucose, cardiac histology, or Troponin I levels. Additionally, the combination led to reduced dose-related body weight loss and increased cytokines compared to a high dose of doxorubicin alone, indicating its potential as an adjunct therapy for improved effectiveness against breast carcinoma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Teofilo Vasconcelos, Fabiola Prezotti, Francisca Araujo, Carlos Lopes, Ana Loureiro, Sara Marques, Bruno Sarmento
Summary: Resveratrol, a promising anti-oxidant drug candidate, was formulated into third-generation solid dispersions using Soluplus and Tween 80 as carriers, significantly enhancing its solubility. In vivo studies showed that formulations containing 15% poloxamer 407 demonstrated the most promising results, with a 2.5 fold increase in bioavailability compared to formulations without poloxamer 407.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Jaqueline Aparecida Duarte, Eliza Rocha Gomes, Andre Luis Branco De Barros, Elaine Amaral Leite
Summary: A novel pH-sensitive liposomal formulation capable of co-encapsulating DOX and SIM was investigated for its potential in breast tumor treatment. The liposomal formulations showed a mean diameter less than 200 nm and good size distribution. Results indicated that a DOX:SIM molar ratio of 2:1, whether in free or encapsulated form, exhibited stronger inhibitory effects on breast cancer cell lines and demonstrated synergistic combination rates. These findings suggest the promising potential of the co-encapsulated liposome for breast tumor treatment.
Article
Pharmacology & Pharmacy
Sergey Brezgin, Anastasiya Kostyusheva, Natalia Ponomareva, Ekaterina Bayurova, Alla Kondrashova, Anastasia Frolova, Olga Slatinskaya, Landysh Fatkhutdinova, Georgy Maksimov, Mikhail Zyuzin, Ilya Gordeychuk, Alexander Lukashev, Sergey Makarov, Alexander Ivanov, Andrey A. Zamyatnin Jr, Vladimir Chulanov, Alessandro Parodi, Dmitry Kostyushev
Summary: Biological nanoparticles, such as extracellular vesicles (EVs) and extracellular vesicle-mimetic nanovesicles (EMNVs), have been extensively studied as drug delivery vehicles in medical applications. This study investigated the properties and drug delivery abilities of EVs and EMNVs, and analyzed their use for delivering the chemotherapeutic drug doxorubicin. EMNVs were found to be more effectively internalized, while EVs showed higher intracellular release of doxorubicin.
Article
Plant Sciences
Gloria A. Guillen-Melendez, Sheila A. Villa-Cedillo, Raymundo A. Perez-Hernandez, Uziel Castillo-Velazquez, Daniel Salas-Trevino, Odila Saucedo-Cardenas, Roberto Montes-de-Oca-Luna, Christian A. Gomez-Tristan, Aime Jazmin Garza-Arredondo, Diana Elisa Zamora-Avila, Maria de Jesus Loera-Arias, Adolfo Soto-Dominguez
Summary: The study demonstrated the cytotoxic effects of Acalypha monostachya extracts on human tumor cell lines, showing potential antineoplastic effects. The extracts induced morphological changes in tumor cells, with the methanolic and hexane extracts exhibiting stronger cytotoxic effects.
Article
Food Science & Technology
Semih Dalkilic, Ismail Korkmaz, Lutfiye Kadioglu Dalkilic, Gokhan Akay, Songul Fidan
Summary: Cancer is a major cause of worldwide deaths, with increasing incidence and low survival rates. Researchers are actively studying new diagnostic methods, candidate drug molecules, and molecular pathways for targeted new drugs. In this study, the cytotoxic and apoptotic effects of Smilax aspera L. root extracts were investigated for the first time, showing significant cytotoxic effects on three different cancer cell lines and inducing apoptosis in one cell line. This highlights the strategic importance of S. aspera in cancer treatment.
Article
Oncology
Marcin Michalak, Michel S. Lach, Sylwia Borska, Blazej Nowakowski, Kazuo Umezawa, Wiktoria M. Suchorska
Summary: Ovarian cancer is a lethal gynaecological malignancy with a reduced survival rate due to difficulty in early detection and chemoresistance. Activation of the NF-kappa B signalling pathway is associated with poor prognosis in patients. Developing inhibitors for this pathway has become a target in cancer therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Catherine E. Vasey, Robert J. Cavanagh, Vincenzo Taresco, Cara Moloney, Stuart Smith, Ruman Rahman, Cameron Alexander
Summary: Glioblastoma is the most common and aggressive brain tumor in adults, with limited survival despite multimodal treatments. PEGylated poly(lactide)-poly(carbonate)-doxorubicin nanoparticles showed tumor cell-killing effects, and the release of DOX from polymer-DOX conjugate nanoparticles in thermosensitive matrices was effective over clinically relevant time scales. Future in vivo assessments are needed to evaluate the potential of these nanoparticles in penetrating brain parenchyma.
Article
Pharmacology & Pharmacy
Bin Jiang, Qi Tian, Chuqiang Shu, Jing Zhao, Min Xue, Shujuan Zhu
Summary: The study demonstrated that RES enhances the anti-cancer effects of cis-platinum on cervical cancer cells by activating the SIRT3-related anti-oxidative pathway, potentially serving as a synergistic agent in the treatment of cervical cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Sylwia Borska
Summary: Cancer diseases pose a major challenge in clinical medicine globally, with drug resistance being a significant issue. Natural compounds, particularly polyphenols, are believed to have pleiotropic effects on cells and toxic effects on cancer cells, showing promise as a new approach to cancer treatment. Studies on the effectiveness of resveratrol in treating cancer, including reversing multidrug resistance, are ongoing and may provide valuable insights for future in vivo and clinical studies.
Article
Chemistry, Medicinal
Claudia Mugnaini, Magdalena Kostrzewa, Marta Bryk, Ali Mokhtar Mahmoud, Antonella Brizzi, Stefania Lamponi, Gianluca Giorgi, Francesca Ferlenghi, Federica Vacondio, Paola Maccioni, Giancarlo Colombo, Marco Mor, Katarzyna Starowicz, Vincenzo Di Marzo, Alessia Ligresti, Federico Corelli
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Engy A. Abdel-Rahman, Eman A. Zaky, Mahmoud Aboulsaoud, Reham M. Elhossiny, Walaa Y. Youssef, Ali M. Mahmoud, Sameh S. Ali
Summary: The study found that there are mitochondrial and immune dysfunctions in platelets and neutrophils of individuals with autism spectrum disorder (ASD), and hyperbaric oxygen therapy (HBOT) does not significantly improve these deficits.
FREE RADICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Engy A. Mahrous, Ahmed M. Al-Abd, Maha M. Salama, Magda M. Fathy, Fathy M. Soliman, Fatema R. Saber
Summary: The Myrteacae family is a rich source of phloroglucinols, with two new phloroglucinol derivatives showing selective antiproliferative action against colorectal cancer cells. The compounds may induce cytotoxicity through both necrosis and apoptosis pathways, suggesting potential as selective chemotherapeutic agents.
Article
Cell Biology
Magdalena Kostrzewa, Ali Mokhtar Mahmoud, Roberta Verde, Federica Scotto di Carlo, Fernando Gianfrancesco, Fabiana Piscitelli, Alessia Ligresti
Summary: Research has shown significant alterations in the endocannabinoid tone during bone cell differentiation and growth processes, affecting metabolic enzymes and endogenous ligands that directly impact bone remodeling. These findings contribute to a better understanding of bone cell physiology and offer potential therapeutic strategies for preventing bone-related metabolic changes throughout the lifespan.
Article
Medicine, Research & Experimental
Rinad A. Algehani, Raefa Abou Khouzam, Gehan A. Hegazy, Aliaa A. Alamoudi, Ali M. El-Halawany, Riham S. El Dine, Ghada A. Ajabnoor, Fahad A. Al-Abbasi, Mohammed A. Baghdadi, Ibrahim Elsayed, Masao Hattori, Ahmed M. Al-Abd
Summary: A synergistic effect in terms of anticancer properties was observed when colossolactone-G was combined with 5-FU and GCB, influencing both apoptosis and autophagic cell death mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Mahmoud Zaki El-Readi, Ahmed M. Al-Abd, Mohammad A. Althubiti, Riyad A. Almaimani, Hiba Saeed Al-Amoodi, Mohamed Lotfy Ashour, Michael Wink, Safaa Yehia Eid
Summary: Plant secondary metabolites are commonly used in pharmaceutical agents, especially in cancer therapy, to reduce the doses of chemotherapeutic drugs, enhance cell growth inhibition, avoid side effects, and increase cancer cell sensitivity to chemotherapy. They interact with membrane proteins and nucleic acids, inducing apoptosis to overcome multidrug resistance. Consuming dietary supplements containing secondary metabolites may affect the bioavailability, efficacy, and safety of drugs that are substrates of P-glycoprotein.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Reham K. Abuhijjleh, Samiullah Shabbir, Ahmed M. Al-Abd, Nada H. Jiaan, Shahad Alshamil, Eman M. El-labbad, Sherief Khalifa
Summary: Marine life provides unique bioactive compounds, with different marine regions such as the Red Sea and the Persian Gulf having diverse metabolic pathways due to varying environmental conditions, potentially containing interesting bioactive compounds. Despite the proven biodiversity of the Persian Gulf and the Gulf of Oman, research on bioactive metabolites derived from marine organisms in these areas is limited.
Article
Biochemistry & Molecular Biology
Sara Kebbi, Maria Letizia Ciavatta, Ali Mokhtar Mahmoud, Marianna Carbone, Alessia Ligresti, Ramdane Seghiri, Margherita Gavagnin
Summary: The study aimed to investigate the chemical composition of Algerian plant Centaurea omphalotricha, leading to the discovery of two new bioactive compounds. These compounds showed antiproliferative properties on HeLa cells, indicating their potential as anticancer agents.
Article
Biochemistry & Molecular Biology
Tarik A. Mohamed, Abdelsamed Elshamy, Mahmoud A. A. Ibrahim, Mohamed A. M. Atia, Rania F. Ahmed, Sherin K. Ali, Karam A. Mahdy, Shifaa O. Alshammari, Ahmed M. Al-Abd, Mahmoud F. Moustafa, Abdel Razik H. Farrag, Mohamed-Elamir F. Hegazy
Summary: This study investigated the anti-ulcer activity of ST-1 isolated from Nephthea species using in vivo experiments and molecular docking techniques, showing significant anti-ulcer effects and potential modulation of the PI3K signaling pathway.
Article
Medicine, Research & Experimental
Afnan A. Alqarni, Aliaa A. Alamoudi, Rasha M. Allam, Ghada M. Ajabnoor, Steve M. Harakeh, Ahmed M. Al-Abd
Summary: In this study, it was found that the polyphenolic mixture PFM exhibits anticancer effects against breast cancer cells by inhibiting cell proliferation, inducing apoptosis, modulating gene expression, and inhibiting cell migration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Analytical
Tarek Elawady, Ahmed M. Al-Abd, Alaa Khedr, Nahed EL-Enany, Fathalla Belal
Summary: A sensitive LC-MS/MS method was developed to determine the concentration of SOR and its metabolite SNX in colorectal cancer cells. The method was able to monitor the cellular uptake and entrapment of both compounds, and confirmed the positive effect of ginger derived compounds on SOR activity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Gianquinto, Federica Sodano, Barbara Rolando, Magdalena Kostrzewa, Marco Allara, Ali Mokhtar Mahmoud, Poulami Kumar, Francesca Spyrakis, Alessia Ligresti, Konstantin Chegaev
Summary: In this study, a series of compounds were designed and synthesized, and their affinity for hCB1R and hCB2R was determined. Through molecular modeling and structure-activity relationship studies, the chemical features responsible for hCB2R selectivity were identified. Additionally, a computational model capable of predicting the functional activity of hCB2R ligands was proposed. Four pure hCB2R-selective agonists were discovered, which can serve as a starting point for developing more potent ligands.
Article
Chemistry, Medicinal
Reham Khaled Abuhijjleh, Dalia Yousef Al Saeedy, Naglaa S. Ashmawy, Ahmed E. Gouda, Sameh S. Elhady, Ahmed Mohamed Al-Abd
Summary: The bioactive marine secondary metabolite Terrein enhances the anticancer properties of gemcitabine (GCB) in colorectal cancer cells, with synergistic effects observed in some cell lines under normoxic conditions. However, the combination treatment has an antagonistic effect in other cell lines and under hypoxic conditions. The combination treatment induces apoptosis and affects extracellular amino acid metabolism.
Article
Chemistry, Multidisciplinary
Mai Hussin Radi, Riham A. A. El-Shiekh, Ali M. M. El-Halawany, Ahmed M. M. Al-Abd, Essam Abdel-Sattar
Summary: This study evaluated the antiproliferative activity of E. grantii aerial parts, and found that the dichloromethane fraction showed promising cytotoxic activity against breast cancer cell lines. Eight compounds were isolated from the active fraction, and euphylbenzoate exhibited the best anticancer activity. These results demonstrate that E. grantii aerial parts contain active compounds with significant antiproliferative potential.
Article
Chemistry, Multidisciplinary
Ola E. Abdel-Sattar, Rasha M. Allam, Ahmed M. Al-Abd, Ali M. El-Halawany, Ahmed M. EL-Desoky, Shanaz O. Mohamed, Sherouk Hussein Sweilam, Mohammad Khalid, Essam Abdel-Sattar, Meselhy R. Meselhy
Summary: This study aimed to investigate the cytotoxicity and chemomodulatory effects of PN4 and PN5 isolated from Phyllanthus niruri on adriamycin multidrug-resistant breast cancer cells (MCF-7(ADR)) and elucidate their mechanism of action. The results showed that both compounds exhibited moderate potency against MCF-7 and MCF-7(ADR), and significantly synergized the anticancer properties of DOX. The chemomodulatory effect of both compounds was achieved through promoting DOX-induced cell cycle interference and apoptosis induction.