Article
Biotechnology & Applied Microbiology
Jian Yao, Jian-wen Hui, Yan-jun Chen, Dong-yang Luo, Jiang-shu Yan, Yi-fan Zhang, Yuan-xiang Lan, Xiu-rui Yan, Zhi-hua Wang, Heng Fan, Xe-chun Xia
Summary: In this study, it was found that Lycium barbarum polysaccharide (LBP) inhibits glioma cell proliferation by promoting the expression of period 2 (PER2) through the PKA-CREB pathway. LBP also inhibits lipid synthesis by downregulating SREBP1c and its target genes, which depends on the expression of PER2. Moreover, PER2 negatively regulates the expression of SREBP1c by suppressing the PI3K/AKT/mTOR pathway. This study provides insights into an alternative drug for glioma treatment and elucidates its potential mechanism.
CANCER GENE THERAPY
(2023)
Article
Nanoscience & Nanotechnology
Sohyeon Park, Sungwon Jung, Jiwoong Heo, Won-Gun Koh, Sangmin Lee, Jinkee Hong
Summary: This study developed a polysaccharide platform to efficiently deliver C-phycocyanin (C-PC) to myoblast, reducing the cost of cell medium and improving myoblast proliferation in a serum-reduced environment. This innovative technology may have value in meat production.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Georg H. J. Weymar, Yotam Bar -On, Thiago Y. Oliveira, Christian Gaebler, Victor Ramos, Harald Hartweger, Gaelle Breton, Marina Caskey, Lillian B. Cohn, Mila Jankovic, Michel C. Nussenzweig
Summary: The study discovered that clones of latent cells carrying dormant HIV-1 viruses mainly exist in a specific subgroup of CD4(+) T cells, which are predominantly T effector memory cells with distinctive gene expression. This finding opens up new possibilities for eradicating HIV-1.
Article
Chemistry, Applied
Lucas de Souza Soares, Barbara Teixeira Gomes, Gustavo Leite Miliao, Roney Alves da Rocha, Alvaro Vianna Novaes de Carvalho Teixeira, Jane Selia dos Reis Coimbra, Eduardo Basilio de Oliveira
Summary: A method to improve the elasticity of hydrogels and slow down the release of dyes was developed by partially replacing the gelling agent with chitosan.
CARBOHYDRATE POLYMERS
(2021)
Article
Nutrition & Dietetics
Patricia Ruiz-Iglesias, Sheila Estruel-Amades, Malen Massot-Cladera, Angels Franch, Francisco J. Perez-Cano, Margarida Castell
Summary: Stressful situations such as intense exercise can disrupt the immune system and gastrointestinal function. This study investigated the effect of hesperidin consumption in rats undergoing intense training and exhaustion tests. Results showed that while hesperidin did not prevent immune system changes, it enhanced IgA synthesis in the intestine, potentially strengthening the immune barrier in stressful situations.
Article
Multidisciplinary Sciences
Yushuai Ma, Ying Zhao, Rui Chen, Wanru Sun, Yanxia Zhang, Haixia Qiao, Yueli Chang, Shaoping Kang, Yutuo Zhang
Summary: Nontypeable Haemophilus influenzae (NTHi) is a common opportunistic pathogen that causes otitis media in children and acute exacerbation of chronic obstructive pulmonary disease (COPD) in adults. P6-loaded mannose-modified chitosan microspheres (P6-MCMs) have been found to enhance humoral and cellular immune responses, effectively prevent NTHi infection, and reduce inflammation in the nasal mucosa and lung.
Article
Nanoscience & Nanotechnology
Kaixuan Zhao, Siqi Pu, Liyun Sun, Dongmei Zhou
Summary: In this study, the researchers successfully synthesized gentiopicroside-loaded chitosan nanoparticles and evaluated their therapeutic effects on psoriasis. The nanoparticles showed anti-psoriasis activity and inhibited keratinocyte proliferation. Furthermore, they improved the severity of skin lesions in psoriasis-like mice models. These findings suggest that gentiopicroside-loaded chitosan nanoparticles could be a potential treatment strategy for psoriasis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
N. Radyukhina, N. Yu Ruleva, A. Yu Filatova, T. Aref'eva
Summary: Statins have an impact on the functional activity of CD4(+) T lymphocytes, including inhibiting cell proliferation and regulating the expression of active caspase-3. Lipophilic atorvastatin shows cellular effects at lower concentrations compared to hydrophilic rosuvastatin.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Joaquin Arata Badano, Noelia Vanden Braber, Yanina Rossi, Ladislao Diaz Vergara, Luciana Bohl, Carina Porporatto, R. Dario Falcone, Mariana Montenegro
CARBOHYDRATE POLYMERS
(2019)
Article
Food Science & Technology
Yanina E. Rossi, Luciana P. Bohl, Noelia L. Vanden Braber, Maria B. Ballatore, Franco M. Escobar, Romina Bodoira, Damian M. Maestri, Carina Porporatto, Lilia R. Cavaglieri, Mariana A. Montenegro
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Chemistry, Physical
M. Soledad Orellano, Gabriel S. Longo, Carina Porporatto, N. Mariano Correa, R. Dario Falcone
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Microbiology
N. Berardo, L. Bohl, C. Porporatto, M. E. F. Nader-Macias, C. Bogni, M. Pellegrino
BENEFICIAL MICROBES
(2020)
Article
Immunology
Agustin Conesa, Silvana Dieser, Claudia Barberis, Cesar Bonetto, Mirta Lasagno, Carlos Vay, Liliana Odierno, Carina Porporatto, Claudia Raspanti
MICROBIAL PATHOGENESIS
(2020)
Article
Agriculture, Dairy & Animal Science
N. Garimano, L. I. Diaz Vergara, A. D. Kim, E. E. Badin, S. Sodero, A. M. Bernal, D. D. Gonzalez, M. M. Amaral, A. R. Lespinard, C. Porporatto, M. A. Montenegro, M. S. Palermo, M. Larzabal, A. A. Cataldi, C. Ibarra, F. Sacerdoti
Summary: The study demonstrates that hyperimmune colostrum against Stx2 maintains its protective properties after pasteurization and spray-drying processes, successfully neutralizing Stx2 cytotoxicity and protecting against EHEC infection. Further research is needed to explore its potential for controlling EHEC infections.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Entomology
Andres G. Jacquat, Virginia L. Usseglio, Luciana Bohl, Fernanda Achimon, Carina Porporatto, Vanessa A. Areco, Romina P. Pizzolitto, Julio A. Zygadlo, Maria P. Zunino, Jose S. Dambolena
Summary: Maize grains at physiological maturity can respond to volatile fungal compounds by increasing their basal oxylipin metabolism, which could have agronomic implications. The exposure to volatiles emitted by Fusarium verticillioides led to an increase in gene expression and enzymatic activity related to oxylipin pathways in the grains.
JOURNAL OF STORED PRODUCTS RESEARCH
(2021)
Article
Immunology
Luciana Paola Bohl, Paula Isaac, Maria Laura Breser, Maria Soledad Orellano, Silvia Graciela Correa, Nori Graciela Tolosa de Talamoni, Carina Porporatto
Summary: The study found that bacterial biofilms reduce the interaction with epithelial cells, reducing invasion ability. Planktonic cultures seem to induce higher cellular activation than biofilms.
MICROBIAL PATHOGENESIS
(2021)
Article
Environmental Sciences
Romina A. Bachetti, Noelia Urseler, Veronica Morgante, Gabriela Damilano, Carina Porporatto, Elizabeth Agostini, Carolina Morgante
Summary: The study highlights the widespread impact of atrazine pollution in areas with major agricultural land use, showing high concentrations of this compound in surface waters. The distribution of atrazine varies in different seasons, mainly influenced by climate and crop types. Further research is needed to investigate the factors contributing to atrazine pollution in the river basin.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
L. Moine, M. M. Canali, C. Porporatto, S. G. Correa
Summary: Chitosan is a versatile polymer with various biomedical applications, and its chemical modification can give rise to numerous derivatives that are suitable for different types of drug formulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Maria Magdalena Canali, Melanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnes Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel, Masashi Kato, Evelyne Mougneau, Nicolas Glaichenhaus, Philippe Blancou
Summary: An enriched environment reduces lung metastasis in mice, potentially through the reprogramming of inflammatory monocytes and modulation of adrenergic receptors and glucocorticoid receptors signaling. This study highlights the complex role of inflammatory monocytes in cancer progression and suggests a novel anti-tumor mechanism associated with environmental factors.
CANCER CELL INTERNATIONAL
(2023)
Article
Microbiology
Maria Laura Breser, Lucia Tisera, Maria Soledad Orellano, Luciana Paola Bohl, Paula Isaac, Ismael Bianco, Carina Porporatto
Summary: Bovine mastitis, a common and costly disease in dairy cattle, is often caused by non-aureus staphylococci (NAS) which have strong biofilm biomass. The intensity of biofilm biomass is associated with antibiotic resistance, and chitosan (Ch) shows potential to counteract the biofilm protection. This research suggests considering bacterial biomass when designing new antimicrobial therapies to improve cure rates by reducing antibiotic concentrations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Prashanth K. Kandalla, Julien Subburayalu, Clement Cocita, Berengere de Laval, Elena Tomasello, Johanna Iacono, Jessica Nitsche, Maria M. Canali, Wilfried Cathou, Gilles Bessou, Noushin Mossadegh-Keller, Caroline Huber, Guy Mouchiroud, Roland P. Bourette, Marie-France Grasset, Martin Bornhaeuser, Sandrine Sarrazin, Marc Dalod, Michael H. Sieweke
Summary: Therapies involving M-CSF can help boost antiviral immune response in immunosuppressed individuals, particularly those who have undergone hematopoietic cell transplantation. M-CSF promotes myelopoiesis and NK cell differentiation, leading to increased NK cell numbers and antiviral activity.
EMBO MOLECULAR MEDICINE
(2023)
Article
Chemistry, Physical
M. Soledad Orellano, Luciana P. Bohl, Maria L. Breser, Paula Isaac, R. Dario Falcone, Carina Porporatto
Summary: The research evaluated the antimicrobial activity of differently-synthesized chitosan nanoparticles against bovine mastitis pathogens and their toxicity in bovine cells, to explore their attributes for preventing and treating intramammary infections. The results showed that chitosan nanoparticles had a significant bactericidal effect on bovine mastitis pathogens and were able to inhibit biofilm formation.