期刊
CELL METABOLISM
卷 16, 期 2, 页码 139-141出版社
CELL PRESS
DOI: 10.1016/j.cmet.2012.07.009
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资金
- Medical Research Council [MR/J001465/1] Funding Source: Medline
- Medical Research Council [MR/J001465/1] Funding Source: researchfish
- MRC [MR/J001465/1] Funding Source: UKRI
Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway.
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