Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage. A recent report (Gupta et al., 2010) identifies the zinc finger protein Zfp423 as a determining factor in preadipocyte commitment.
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