Article
Anthropology
Asier Vallejo, Jaime Gea, Ane Gorostizu-Orkaiztegi, Josep Maria Verges, Patricia Martin, M. Carmen Sampedro, Alicia Sanchez-Ortega, M. Aranzazu Goicolea, Ramon J. Barrio
Summary: A new method for the analysis of early husbandry practices was used in this study, showing that bile acid analysis can be useful for identifying remains of ruminant residues. The progesterone/deoxycholic acid ratio can be used as a biomarker for herd management.
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2022)
Article
Oncology
Dong Hang, Xiaolin Yang, JiaYi Lu, Chong Shen, Juncheng Dai, Xiangfeng Lu, Guangfu Jin, Zhibin Hu, Dongfeng Gu, Hongxia Ma, Hongbing Shen
Summary: This study identified a panel of plasma metabolites associated with hepatocellular carcinoma (HCC) and established a potential model for predicting HCC risk based on metabolites analysis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Rohit Loomba, Lei Ling, Duy M. Dinh, Alex M. DePaoli, Hsiao D. Lieu, Stephen A. Harrison, Arun J. Sanyal
Summary: This study investigated the impact of aldafermin on the gut microbiota in patients with NASH. The results showed that aldafermin had a significant effect on the stability of the gut microbial community, leading to an enrichment in the rare genus Veillonella, which may be influenced by aldafermin-mediated suppression of bile acid synthesis.
Review
Medicine, Research & Experimental
Ai-jin Xie, Chu-tian Mai, Yi-Zhun Zhu, Xian-Cheng Liu, Ying Xie
Summary: Bile acids, derived from cholesterol in the liver, play crucial roles in intestinal lipid absorption and various physiological functions. Some bile acids have therapeutic potential, but accumulation of toxic bile acids can cause cell damage. Changes in bile acid metabolism and interactions with gut microbiota are key factors in the pathogenesis of metabolic diseases.
Article
Toxicology
R. E. H. Karsten, N. J. W. Krijnen, W. Maho, H. Permentier, E. Verpoorte, P. Olinga
Summary: This study developed a mouse precision-cut liver slice model to study drug-induced cholestasis and assess its development. The findings show that cholestatic drugs increased intracellular bile-acid concentration and modulated bile-transporter genes. Chlorpromazine induced the most pronounced cholestasis and exhibited some transition into fibrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Chisayo Kozuka, Vissarion Efthymiou, Vicencia M. Sales, Liyuan Zhou, Soravis Osataphan, Yixing Yuchi, Jeremy Chimene-Weiss, Christopher Mulla, Elvira Isganaitis, Jessica Desmond, Suzuka Sanechika, Joji Kusuyama, Laurie Goodyear, Xu Shi, Robert E. Gerszten, Cristina Aguayo-Mazzucato, Priscila Carapeto, Silvania DaSilva Teixeira, Darleen Sandoval, Direna Alonso-Curbelo, Lei Wu, Jun Qi, Mary-Elizabeth Patti
Summary: The study reveals that bromodomain-containing proteins (Brds) play a role in epigenetic regulation of glucose metabolism. Treatment with the bromodomain inhibitor JQ-1 leads to hyperglycemia and glucose intolerance in mice, while reducing insulin secretion. It also inhibits fibroblast growth factor (FGF) signaling in the liver and reduces FGF15 expression in the ileum. Brd4 is identified as a novel transcriptional regulator of intestinal FGF15/19 and contributes to the gut-liver axis and systemic glucose metabolism.
Review
Medicine, General & Internal
Samy A. Azer, Rana Hasanato
Summary: The study aimed to determine the effectiveness of bile acids as markers of liver dysfunction, however, results showed inconsistencies and a lack of solid evidence to support the use of bile acids as biomarkers of liver injury.
Review
Biochemistry & Molecular Biology
Yulia Shulpekova, Maria Zharkova, Pyotr Tkachenko, Igor Tikhonov, Alexander Stepanov, Alexandra Synitsyna, Alexander Izotov, Tatyana Butkova, Nadezhda Shulpekova, Natalia Lapina, Vladimir Nechaev, Svetlana Kardasheva, Alexey Okhlobystin, Vladimir Ivashkin
Summary: Bile acids are important organic components of bile, playing a significant role in bile outflow and biological regulation. Despite the complexity of bile acids, they hold great potential for research and pharmacological applications.
Article
Toxicology
Jingxuan Wang, Wouter Bakker, Weijia Zheng, Laura de Haan, Ivonne M. C. M. Rietjens, Hans Bouwmeester
Summary: This study found that deoxynivalenol (DON) inhibits the reabsorption of bile acids in the intestines by reducing the expression of bile acid transporters. This has an impact on the metabolism of bile acids in the intestines. The results of this study provide new insights into the hazards of DON exposure.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Medical Laboratory Technology
Lars-Olav Harnisch, Diana Mihaylov, Thomas Bein, Christian Apfelbacher, Michael Kiehntopf, Michael Bauer, Onnen Moerer, Michael Quintel
Summary: This study investigates the specific pattern of bile acids associated with acute respiratory distress syndrome (ARDS) and the changes over time. The results reveal a unique bile acid profile in ARDS patients compared to other diseases, indicating a shift in the synthesis pathway. The higher levels of TCDCA in non-survivors on day 5 suggests its potential as a prognostic marker for survival.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Microbiology
L. N. Lucas, K. Barrett, R. L. Kerby, Q. Zhang, L. E. Cattaneo, D. Stevenson, F. E. Rey, D. Amador-Noguez
Summary: Gut bacteria play a critical role in modifying primary bile acids synthesized by the host, leading to the production of secondary bile acids that can regulate metabolic processes and influence gut microbiota composition. Through screening 72 bacterial isolates, this study identified 43 isolates capable of modifying unconjugated bile acids, expanding the known diversity of bacteria involved in bile acid transformations. The discovery of novel microbial conjugated bile acids and previously undescribed species highlights the importance of understanding the interactions between the microbiome, bile acid pool composition, and human health.
Article
Biochemistry & Molecular Biology
Zhuan Song, Jingqing Chen, Yun Ji, Qing Yang, Yinfeng Chen, Fengchao Wang, Zhenlong Wu
Summary: Amuc is a pili-like protein found abundantly on the outer membrane of Akkermansia muciniphila, and has been shown to have anti-obesity effects through TLR2 activation. This study used TLR2 knockout mice to investigate the mechanism of action. The results demonstrated that Amuc decreased body weight and lipid deposition by regulating fatty acid metabolism, reducing bile acid synthesis, and strengthening the intestinal barrier function. The study also found that Amuc altered the gut microbiota composition, which may contribute to its effects on the intestinal barrier in high-fat diet-induced mice. These findings support the potential use of Amuc as a therapy for obesity-associated metabolic syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Purnima Gunness, Honglei Zhai, Barbara A. Williams, Dagong Zhang, Michael J. Gidley
Summary: The study found that pectin can reduce plasma cholesterol and triglyceride levels, increase total bile acid levels, and have different effects on intestinal cholesterol compared to mango; pectin has prebiotic properties and promotes the increase of therapeutic bile acid ursodesoxycholic acid (UDCA).
FOOD HYDROCOLLOIDS
(2021)
Article
Multidisciplinary Sciences
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud
Summary: The study identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells, protecting the small intestine from bile acid toxicity and inflammation. Activation of CAR in T-eff cells infiltrating the small intestine induced large-scale transcriptional reprogramming and promoted the expression of the anti-inflammatory cytokine IL-10.
Article
Nutrition & Dietetics
Joaquin Garcia-Cordero, Alba Martinez, Carlos Blanco-Valverde, Alicia Pino, Veronica Puertas-Martin, Ricardo San Roman, Sonia de Pascual-Teresa
Summary: The aim of this study was to analyze the effects of cocoa flavanols and red berry anthocyanins on cardiovascular biomarkers. A randomized, parallel-group study was performed on 60 healthy volunteers who consumed cocoa powder, red berry mixture, or a combination of both for 12 weeks. The group that consumed cocoa showed reduced TMAO and uric acid levels, increased FMD values, and improved cardiovascular function. This study highlights the positive modulation of microbiota metabolism and the potential health benefits of cocoa and red berries.
