期刊
CELL HOST & MICROBE
卷 16, 期 5, 页码 562-568出版社
CELL PRESS
DOI: 10.1016/j.chom.2014.10.009
关键词
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资金
- National Institutes of Health [2 R01 AI079031-05A1, 1 R01 AI107301-01, 1 R56 AI106005-01]
- Walter Reed Army Institute of Research
- Bill and Melinda Gates Foundation
- Grand Challenge Program of Princeton University
- German Research Foundation (Deutsche Forschungsgemeinschaft)
Uptake of hepatitis C virus (HCV) into hepatocytes is an orchestrated process, involving numerous host factors, virion-associated lipoproteins, and a growing number of cell-associated factors. Several of these factors likely contribute to the hepatotropism and limited host range of this virus. Discerning the minimal set of human-specific factors required for viral uptake into nonhuman cells has facilitated the development of small animal models with inheritable HCV susceptibility. This review summarizes current knowledge of host factors required for HCV entry, the molecular mechanisms underlying HCV entry into hepatocytes, and aspects of viral entry contributing to HCV host tropism.
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