Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

Overview and Findings from the Rush Memory and Aging Project

(2013) David A. Bennett et al.   Current Alzheimer Research

Caspase-6 activity predicts lower episodic memory ability in aged individuals

(2013) Jasmine Ramcharitar et al.   NEUROBIOLOGY OF AGING

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning

(2013) Corey L. Cusack et al.   Nature Communications

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

(2012) Valeria Uribe et al.   HUMAN MOLECULAR GENETICS

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition

(2010) S. M. Leong et al.   BLOOD

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

Intact Memory in TGF-β1 Transgenic Mice Featuring Chronic Cerebrovascular Deficit: Recovery with Pioglitazone

(2010) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

(2010) D. Halawani et al.   JOURNAL OF NEUROSCIENCE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

(2010) Katya J Park et al.   NATURE NEUROSCIENCE

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

(2010) S N Sivananthan et al.   Cell Death & Disease

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

(2009) Steffen Albrecht et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

(2008) Guy Klaiman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent

(2008) Christian Rust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

(2008) Guy Klaiman et al.   MOLECULAR & CELLULAR PROTEOMICS