Article
Biochemistry & Molecular Biology
So Rae Song, Seung Un Seo, Seon Min Woo, Ji Yun Yoon, Simmyung Yook, Taeg Kyu Kwon
Summary: In this study, the research focused on the effect of traditional Chinese medicinal herb, Tubeimoside-1 (TBMS-1), on the sensitization of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The results showed that combination therapy using TBMS-1 and TRAIL increased apoptotic cell death. Mechanistically, TBMS-1 destabilized c-FLIP expression by downregulating STAMBPL1, a deubiquitinase (DUB). Moreover, knockdown of STAMBPL1 enhanced TRAIL-mediated apoptosis via c-FLIP downregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang
Summary: TNF stimulation generates pro-survival signals by activating NF-kappa B and restricting death signaling. Bclaf1 has been identified as a novel component of TNF anti-apoptotic program, promoting CFLAR transcription downstream of NF-kappa B activation. The depletion of Bclaf1 sensitizes cells to TNF-induced apoptosis and exacerbates small intestine injury in mice.
Article
Multidisciplinary Sciences
Shima Lotfollahzadeh, Elaheh Sadat Hosseini, Hooman Mahmoudi Aznaveh, Maryam Nikkhah, Saman Hosseinkhani
Summary: This study successfully fabricated a promising nanohybrid system to improve the therapeutic efficacy of TRAIL. By conjugating TRAIL with graphene quantum dots, the study demonstrated enhanced functional stability and effective anticancer activity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zhi-Qiang Bai, Xiaofang Ma, Bin Liu, Tao Huang, Kaifeng Hu
Summary: This study provides a structural basis for understanding the interaction between c-FLIP and procaspase-8 and the molecular mechanisms of c-FLIP in regulating cell death.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Federica Laudisi, Teresa Pacifico, Claudia Maresca, Anderson Luiz-Ferreira, Sara Antonelli, Angela Ortenzi, Alfredo Colantoni, Antonio Di Grazia, Eleonora Franze, Marco Colella, Davide Di Fusco, Giuseppe S. Sica, Ivan Monteleone, Giovanni Monteleone, Carmine Stolfi
Summary: Colorectal cancer is a major cause of cancer-related death, and current treatments are not effective against advanced disease. Researchers have found that the anthelmintic drug rafoxanide can enhance the sensitivity of colorectal cancer cells to TRAIL, a targeted therapy. This discovery suggests that rafoxanide could be a potential treatment option for overcoming TRAIL resistance in colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Anderson Luiz-Ferreira, Teresa Pacifico, Alefe Cardoso Cruz, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: TRAIL is a promising anticancer agent that selectively induces apoptosis in transformed cells, while flavonoids, natural compounds found in plants, have shown competence in enhancing TRAIL-induced apoptosis. However, bioavailability issues are the main limitations for the clinical use of flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yang Cao, Ying He, Litao Yang, Zhou Luan
Summary: Studies have shown that CR-31 treatment can counter the resistance to TRAIL in GBC cells, increase sensitivity to apoptosis, and may serve as a novel therapeutic strategy.
Review
Oncology
Esra Kupeli Akkol, Iffet Irem Tatli, Gokce Seker Karatoprak, Osman Tuncay Agar, Cigdem Yucel, Eduardo Sobarzo-Sanchez, Raffaele Capasso
Summary: Emodin, a natural compound derived from anthraquinone, demonstrates broad-spectrum anticancer activity by inhibiting proliferation of various cancer cell lines. High purification and appropriate dosage usage of emodin contribute to reduced toxicity and side effects, impacting scientific research significantly.
Article
Chemistry, Medicinal
Gunya Sittithumcharee, Ryusho Kariya, Teerapich Kasemsuk, Rungnapha Saeeng, Seiji Okada
Summary: Acanthoic acid (AA) extracted from the traditional plant Croton oblongifolius Roxb. in Thailand is found to effectively inhibit the proliferation of PEL cells, demonstrating potential as a new treatment option for PEL.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Daichun Li, Xiaojian Liao, Shenghui Zhong, Bingxin Zhao, Shihai Xu
Summary: In this study, eight new galaxamide analogues were synthesized and evaluated for their cytotoxic activities. Analogue Z-6 showed broad spectrum cytotoxic activity against multiple cancer cell lines, with particularly strong activity against MCF-7 cells. Compounds Z-3 and Z-6 were shown to induce apoptosis of MCF-7 cells by arresting the G0/G1 phase of the cell cycle.
Article
Oncology
Karolina Piechna, Aleksandra Zolyniak, Ewa Jablonska, Monika Noyszewska-Kania, Maciej Szydlowski, Bartlomiej Zerek, Maria Kulecka, Izabela Rumienczyk, Michal Mikula, Przemyslaw Juszczynski
Summary: AD-O51.4 exhibits low-nanomolar cytotoxic activity in DLBCL cells, inducing death-receptor (DR) mediated, caspase-dependent apoptosis. Resistance to AD-O51.4 in primary resistant cells may be associated with changes in multiple genes and pathways related to apoptosis, endocytosis, and HDAC-dependent epigenetic reprogramming. Sensitization of resistant DLBCL cells to AD-O51.4 can be achieved with HDAC inhibitors, BCL2 inhibitors, and endocytosis/dynamin inhibitors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chiara Musiu, Simone Caligola, Alessandra Fiore, Alessia Lamolinara, Cristina Frusteri, Francesco Domenico Del Pizzo, Francesco De Sanctis, Stefania Cane, Annalisa Adamo, Francesca Hofer, Roza Maria Barouni, Andrea Grilli, Serena Zilio, Paolo Serafini, Evelina Tacconelli, Katia Donadello, Leonardo Gottin, Enrico Polati, Domenico Girelli, Ildo Polidoro, Piera Amelia Iezzi, Domenico Angelucci, Andrea Capece, Ying Chen, Zheng-Li Shi, Peter J. Murray, Marco Chilosi, Ido Amit, Silvio Bicciato, Manuela Iezzi, Vincenzo Bronte, Stefano Ugel
Summary: Research has shown that FLIP can control cytokine release syndrome (CRS) by activating a STAT3-dependent inflammatory program. Expression of a viral FLIP homolog in myeloid cells can trigger a fatal inflammatory syndrome in mice, characterized by increased cytokine output, lymphopenia, lung injury, and multiple organ dysfunctions. Targeting the STAT3 pathway may help alleviate inflammation, immune disorders, and organ failures associated with CRS.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Chemistry, Inorganic & Nuclear
Louis J. Delinois, Omar De Leon-Velez, Adriana Vazquez-Medina, Alondra Velez-Cabrera, Amanda Marrero-Sanchez, Christopher Nieves-Escobar, Daniela Alfonso-Cano, Delvin Caraballo-Rodriguez, Jael Rodriguez-Ortiz, Jemily Acosta-Mercado, Josue A. Benjamin-Rivera, Kiara Gonzalez-Gonzalez, Kysha Fernandez-Adorno, Lisby Santiago-Pagan, Rafael Delgado-Vergara, Xaiomy Torres-avila, Andrea Maser-Figueroa, Gladimarys Grajales-Aviles, Glorimar I. Miranda Mendez, Javier Santiago-Pagan, Miguel Nieves-Santiago, Vanessa alvarez-Carrillo, Kai Griebenow, Arthur D. Tinoco
Summary: Cytochrome c is a crucial protein involved in cellular processes, with potential as an anticancer therapeutic agent. Understanding its properties and interactions can inform on its ability to overcome limitations of traditional chemotherapy and translate into clinical applications.
Review
Medicine, Research & Experimental
Nasreddine El Omari, Saad Bakrim, Asaad Khalid, Mohammed Albratty, Ashraf N. Abdalla, Learn-Han Lee, Khang Wen Goh, Long Chiau Ming, Abdelhakim Bouyahya
Summary: Cancer progression is influenced by epigenetic events, with histone modification playing a key role in gene expression. Belinostat, a pan-HDAC inhibitor, has shown effectiveness in the treatment of T-cell lymphoma and solid malignancies. By indirectly promoting acetylated histone accumulation and restoring normal gene expressions, belinostat exhibits potential anti-cancer therapeutic effects through various pathways. Additionally, it has been found to increase p21WAF1, a cyclin-dependent kinase inhibitor involved in cell cycle arrest and apoptosis. Investigative trials have supported belinostat's potential as a valuable anti-cancer drug.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Chittaranjan Behera, Kamalpreet Kaur Sandha, Nagma Banjare, Sumera Banoo Malik, Misbah Tabassum, Rajesh Kumar, Amit Kumar, Dilip M. Mondhe, Prem N. Gupta
Summary: Combination chemotherapy can overcome the limitations of monotherapy in cancer treatment by enhancing cytotoxic activity and reducing tumor growth and metastasis. This study investigated the potential of combining methylselenocysteine (MSC) with gemcitabine (GEM). The combination treatment showed significantly enhanced cytotoxicity, induction of apoptosis, and inhibition of tumor invasion and metastasis.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)