期刊
CELL DEATH AND DIFFERENTIATION
卷 17, 期 8, 页码 1222-1229出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2009.160
关键词
muscular dystrophy; animal models; cell therapy; stem cells
资金
- FWO Odysseus [n.G.0907.08]
- Wicka Funds [n.zkb8720]
- University of Minnesota US
- Italian Ministry of University and Scientific Research [2005067555_003]
- Muscular Dystrophy Association, Association Francoise contre les Myopathies
- CARIPLO [2007-5639, 2008-2005]
Understanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment. Cell Death and Differentiation (2010) 17, 1222-1229; doi:10.1038/cdd.2009.160; published online 30 October 2009
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