Article
Oncology
Theresa Bluemn, Jesse Schmitz, Yongwei Zheng, Robert Burns, Shikan Zheng, Joshua DeJong, Luke Christiansen, Olivia Arnold, Jesus Izaguirre-Carbonell, Demin Wang, Aniruddha J. Deshpande, Nan Zhu
Summary: The SWI/SNF nucleosome remodeling complexes have diverse roles in AML leukemogenesis, with Arid2 enhancing leukemia initiation but being required for leukemia maintenance, while the deletion of Arid1b promotes leukemogenesis at any stage.
Article
Biochemistry & Molecular Biology
Yulii V. Shidlovskii, Oleg V. Bylino, Alexander V. Shaposhnikov, Zaur M. Kachaev, Lyubov A. Lebedeva, Valeria V. Kolesnik, Diego Amendola, Giovanna De Simone, Nadia Formicola, Paul Schedl, Filomena Anna Digilio, Ennio Giordano
Summary: The chromatin remodeler SWI/SNF plays a key role in gene activation by opening chromatin structure on promoters and enhancers. A study on Drosophila showed that SWI/SNF factors, specifically the BAP170 and SAYP subunits of the PBAP subfamily, mediate enhancer-dependent transcription of a reporter gene. This suggests that SWI/SNF and its subunits are critical for establishing enhancer-mediated transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Rodrigo O. de Castro, Luciana Previato de Almeida, Agustin Carbajal, Irma Gryniuk, Roberto J. Pezza
Summary: Gametogenesis in mammals involves regulated developmental transitions and changes in gene transcription. SWI/SNF chromatin remodelers are involved in gene transcription and DNA repair, but their role in meiosis is not well understood. Conditional knockout mice for ARID2, a regulatory subunit of PBAF, were generated and compared with BRG1 knockout mice. ARID2 activity is required at the end of prophase I, while BRG1 acts at an early stage of meiosis. Defects in spindle assembly and chromosome-spindle attachment in ARID2 knockout mice are attributed to an increase in aurora B kinase at centromeres. Different PBAF complexes regulate different stages of meiosis and gametogenesis.
Article
Biochemistry & Molecular Biology
N. V. Soshnikova, E. V. Tatarskiy, V. V. Tatarskiy, N. S. Klimenko, A. A. Shtil, M. A. Nikiforov, S. G. Georgieva
Summary: The PBAF complex, with its PHF10 subunit, plays a crucial role in transcriptional regulation and is associated with disease progression in melanoma. The interaction between PHF10 and MYC enhances MYC's activation of genes involved in cell cycle progression. Depletion of PHF10 or MYC leads to G1 accumulation and a senescence-like phenotype in melanoma cells.
Review
Biochemistry & Molecular Biology
Ji-Yun Shang, Xin-Jian He
Summary: Adenosine triphosphate-dependent chromatin remodeling complexes play a crucial role in transcription, DNA replication, and genome stability regulation in eukaryotes. However, the study of chromatin remodeling complexes in plants lags behind yeast and animals. Recent research has identified and characterized the composition and function of chromatin remodeling enzymes in Arabidopsis, providing a foundation for further investigation into the molecular mechanisms.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Li Wang, Jiali Yu, Zishuo Yu, Qianmin Wang, Wanjun Li, Yulei Ren, Zhenguo Chen, Shuang He, Yanhui Xu
Summary: BAF and PBAF are chromatin remodeling complexes that create nucleosome-depleted regions for transcription activation. This study provides structural insights into PBAF-mediated nucleosome association by reporting the structure of a 13-subunit human PBAF in complex with acetylated nucleosome in ADP-BeF3-bound state.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Junjie Yuan, Kangjing Chen, Wenbo Zhang, Zhucheng Chen
Summary: This study reports the structure of the 12-subunit PBAF complex bound to the nucleosome, revealing the binding mode of SMARCA4 and the functional modularity of PBAF. The findings provide mechanistic insights into nucleosome recognition and a structural basis for understanding SMARCA4-related human diseases.
Article
Biophysics
Charles A. Kenworthy, Nayem Haque, Shu-Hao Liou, Panagiotis Chandris, Vincent Wong, Patrycja Dziuba, Luke D. Lavis, Wei-Li Liu, Robert H. Singer, Robert A. Coleman
Summary: Chromatin remodeler PBAF can dynamically target different chromatin states within a live cell and cycles on and off chromatin hubs, with bromodomains potentially playing a direct role in nucleosome remodeling.
BIOPHYSICAL JOURNAL
(2022)
Review
Oncology
Jaren Mullen, Shumei Kato, Jason K. Sicklick, Razelle Kurzrock
Summary: Mutations in ARID1A, a subunit gene of the SWI/SNF chromatin remodeling complex, are common in various cancers and play a crucial role in regulating gene expression related to oncogenesis and tumor suppression. Targeting ARID1A-altered cancers may involve a combination of immune checkpoint blockade and inhibitors of various pathways.ARID1A alterations may also mediate resistance to specific chemotherapies and hormone therapies.
CANCER TREATMENT REVIEWS
(2021)
Article
Cell Biology
Saul Carcamo, Christie B. Nguyen, Elena Grossi, Dan Filipescu, Aktan Alpsoy, Alisha Dhiman, Dan Sun, Sonali Narang, Jochen Imig, Tiphaine C. Martin, Ramon Parsons, Iannis Aifantis, Aristotelis Tsirigos, Julio A. Aguirre-Ghiso, Emily C. Dykhuizen, Dan Hasson, Emily Bernstein
Summary: ARID2 is the most commonly mutated member of the SWI/SNF complex in melanoma. Its deficiency leads to defective assembly of the PBAF complex and redistribution of the BAF complex. ARID2 depletion results in reduced chromatin accessibility and gene expression in certain regions, while enhancers occupied by the BAF complex gain accessibility and gene expression related to invasion. The occupancy of melanoma-relevant transcription factors is affected by altered accessibility, and correlates significantly with the observed transcriptional changes. Furthermore, ARID2-deficient cells acquire the ability to colonize distal organs in multiple animal models.
Article
Oncology
Zhenkun Zhang, Qiujing Li, Shanshan Sun, Zhe Li, Zheng Guo Cui, Menglan Zhang, Qian Liu, Yujie Zhang, Sili Xiong, Shukun Zhang
Summary: The deficiency of SWI/SNF complex is associated with CSC phenotype and worse prognosis in undifferentiated/dedifferentiated gastric carcinoma.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Plant Sciences
Elzbieta Sarnowska, Szymon Kubala, Pawel Cwiek, Sebastian Sacharowski, Paulina Oksinska, Jaroslaw Steciuk, Magdalena Zaborowska, Jakub M. Szurmak, Roman Dubianski, Anna Maassen, Malgorzata Stachowiak, Bruno Huettel, Monika Ciesla, Klaudia Nowicka, Anna T. Rolicka, Saleh Alseekh, Ernest Bucior, Rainer Franzen, Anna Skoneczna, Malgorzata A. Domagalska, Samija Amar, Mohammad-Reza Hajirezaei, Janusz A. Siedlecki, Alisdair R. Fernie, Seth J. Davis, Tomasz J. Sarnowski
Summary: The Arabidopsis ERECTA family of leucine-rich repeat receptor-like kinases (LRR-RLKs) controls various developmental processes and interacts with the SWI/SNF chromatin remodeling complex. The er/erl1/erl2 mutant shows impaired gibberellin signaling, decreased SWI3B protein level, and altered chromatin structure. ERf-SWI/SNF CRC interaction plays an important role in transcriptional control of gibberellin receptors.
Article
Biochemistry & Molecular Biology
Yaoguang Yu, Wei Fu, Jianqu Xu, Yawen Lei, Xin Song, Zhenwei Liang, Tao Zhu, Yuhui Liang, Yuanhao Hao, Liangbing Yuan, Chenlong Li
Summary: The Arabidopsis thaliana bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and play critical roles in genomic targeting. These BRDs interact directly with multiple SWI/SNF subunits, including the BRAHMA (BRM) catalytic subunit, to control gene expression and developmental processes. The bromodomains of BRDs are essential for genomic targeting of SWI/SNF complexes.
Article
Developmental Biology
Yu-Chun Tseng, Jennifer S. Crodian, Ryan Cabot
Summary: This study aims to determine the developmental requirements of two SWI/SNF subunits, SMARCB1 and BRD7, in porcine embryos. The findings indicate that knockdown of SMARCB1 dramatically reduces embryo developmental potential, while knockdown of BRD7 has a less severe impact. Furthermore, knockdown of SMARCB1 alters the expression of NANOG and POU5F1.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Carlos Jimenez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Sole, Marc Masanas, Adria Molero-Valenzuela, Aroa Soriano, Josep Sanchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulalia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura
Summary: Loss of function of mSWI/SNF complexes in neuroblastoma impairs cell proliferation and inhibits tumor invasion and metastasis. Disruption of the BAF complex results in epigenetic repression of invasion-related genes, significantly inhibiting neuroblastoma metastasis. These findings provide important insights for the development of new therapeutic strategies targeting mSWI/SNF complexes in neuroblastoma.
Article
Biochemistry & Molecular Biology
T. N. Portseva, A. V. Brechalov, E. A. Dukhanina, A. G. Stepchenko, E. V. Pankratova, S. G. Georgieva
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Biochemistry & Molecular Biology
N. V. Soshnikova, Yu. P. Simonov, A. V. Brechalov, T. N. Portseva, E. V. Pankratova, S. G. Georgieva
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Biochemistry & Molecular Biology
A. V. Brechalov, M. E. Valieva, S. G. Georgieva, N. V. Soshnikova
Article
Biochemistry & Molecular Biology
Daria Kopytova, Varvara Popova, Maria Kurshakova, Yulii Shidlovskii, Elena Nabirochkina, Alexander Brechalov, Georgii Georgiev, Sofia Georgieva
NUCLEIC ACIDS RESEARCH
(2016)
Article
Multidisciplinary Sciences
Victor V. Tatarskiy, Yuriy P. Simonov, Dmitrii S. Shcherbinin, Alexander V. Brechalov, Sofia G. Georgieva, Nataliya V. Soshnikova
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Varvara V. Popova, Alexander V. Brechalov, Sofia G. Georgieva, Daria V. Kopytova
Meeting Abstract
Biochemistry & Molecular Biology
A. Brechalov, N. Soshnikova, Y. Shidlovskii, S. Georgieva