期刊
CELL CYCLE
卷 13, 期 14, 页码 2306-2310出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.29296
关键词
Hsp70; chaperone; non-oncogene addiction; proteotoxic stress; rational drug targeting
类别
Several years ago a hypothesis was proposed that the survival of cancer cells depends on elevated expression of molecular chaperones because these cells are prone to proteotoxic stress. A critical prediction of this hypothesis is that depletion of chaperones in cancer cells should lead to proteotoxicity. Here, using the major chaperone Hsp70 as example, we demonstrate that its depletion does not trigger proteotoxic stress, thus refuting the model. Accordingly, other functions of chaperones, e. g., their role in cell signaling, might define the requirements for chaperones in cancer cells, which is critical for rational targeting Hsp70 in cancer treatment.
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