Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Growth and aging: a common molecular mechanism

(2016) Mikhail V. Blagosklonny et al.   Aging-US

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

(2016) Alexander A. Goldberg et al.   Aging-US

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Life Span and its Extension by Caloric Restriction

(2012) Alejandro Ocampo et al.   Cell Metabolism

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Caloric Restriction Extends Yeast Chronological Lifespan by Altering a Pattern of Age-Related Changes in Trehalose Concentration

(2012) Pavlo Kyryakov et al.   Frontiers in Physiology

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

In search of housekeeping pathways that regulate longevity

(2011) Adam Beach et al.   CELL CYCLE

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway

(2011) Marco Gallo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Network-Based Approach on Elucidating the Multi-Faceted Nature of Chronological Aging in S. cerevisiae

(2011) Esra Borklu Yucel et al.   PLoS One

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program

(2010) Mikhail V Blagosklonny   CELL CYCLE

Apoptosis in yeast: triggers, pathways, subroutines

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism

(2010) Jeffrey A. Butler et al.   FASEB JOURNAL

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Peroxisome Metabolism and Cellular Aging

(2010) Vladimir I. Titorenko et al.   TRAFFIC

The ageing epigenome: Damaged beyond repair?

(2009) David A. Sinclair et al.   AGEING RESEARCH REVIEWS

A novel function of lipid droplets in regulating longevity

(2009) Alexander A. Goldberg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effect of calorie restriction on the metabolic history of chronologically aging yeast

(2009) Alexander A. Goldberg et al.   EXPERIMENTAL GERONTOLOGY

Aging defined by a chronologic–replicative protein network in Saccharomyces cerevisiae: An interactome analysis

(2009) Fernanda Barea et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

A network biology approach to aging in yeast

(2009) D. R. Lorenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

(2009) Siler H. Panowski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Network strategies to understand the aging process and help age-related drug design

(2009) Gábor I Simkó et al.   Genome Medicine

Toward a Control Theory Analysis of Aging

(2008) Michael P. Murphy et al.   Annual Review of Biochemistry

Chronological aging-induced apoptosis in yeast

(2008) Paola Fabrizio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria-dependent apoptosis in yeast

(2008) C. Pereira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: A short review

(2008) Peter Laun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

(2008) David Gems et al.   Cell Metabolism

MtDNA mutations, functional decline and turnover of mitochondria in aging

(2008) Cheng-Yoong Pang   Frontiers in Bioscience-Landmark

Signaling networks in aging

(2008) Eric L. Greer et al.   JOURNAL OF CELL SCIENCE

Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast

(2008) Hui Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Characterization of Differentiated Quiescent and Nonquiescent Cells in Yeast Stationary-Phase Cultures

(2008) Anthony D. Aragon et al.   MOLECULAR BIOLOGY OF THE CELL

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity

(2008) J. R. Managbanag et al.   PLoS One

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY