Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

(2010) Hiroshi Hirai et al.   CANCER BIOLOGY & THERAPY

Novel dual Src/Abl inhibitors for hematologic and solid malignancies

(2010) Silvia Schenone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

(2010) Alessandra Rossi et al.   FASEB JOURNAL

The molecular background of aggressive B cell lymphomas as a basis for targeted therapy

(2010) Daphne de Jong et al.   JOURNAL OF PATHOLOGY

Selective killing of Burkitt's lymphoma cells by mBAFF-targeted delivery of PinX1

(2010) L Zhang et al.   LEUKEMIA

Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth

(2010) Jiyuan Ke et al.   Molecular Cancer

Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer

(2009) Rebecca E. Schweppe et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma

(2009) C. Annette Hollmann et al.   LEUKEMIA RESEARCH

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

(2009) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

(2008) D. S. Levy et al.   BLOOD

AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression

(2008) Y.-X. Zhang et al.   CANCER RESEARCH

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

(2008) Silvia Schenone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

(2008) Adriano Spreafico et al.   FASEB JOURNAL

Src Directly Phosphorylates Bif-1 and Prevents Its Interaction with Bax and the Initiation of Anoikis

(2008) Hirohito Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib

(2008) C Yang et al.   LEUKEMIA