Article
Geriatrics & Gerontology
Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber, G. R. Scott Budinger, Mitra Lavasani
Summary: Transplantation of young MDSPCs rejuvenates aging knee cartilage by reducing inflammation, promoting regenerative genes, and improving mobility and arthritis-related gait dysfunctions in aged mice. This suggests that MDSPCs may represent a novel therapy to increase mobility and function in aged or OA patients.
Review
Medicine, Research & Experimental
Yingqian Zhu, Jianli Ge, Ce Huang, Hailiang Liu, Hua Jiang
Summary: Aging frailty is a complex geriatric syndrome characterized by disruption of physiological homeostasis and declining health status. Factors such as genome instability, DNA damage, and stem cell exhaustion contribute to the development of frailty with advancing age. Effective interventions are needed to improve the health status of frail patients.
Article
Chemistry, Applied
Cristina Gardini, Antonella Bisio, Giulia Mazzini, Marco Guerrini, Annamaria Naggi, Anna Alekseeva
Summary: Enoxaparin, a widely used antithrombotic drug with a highly microheterogeneous structure, was studied in this research to identify 16 saturated and 23 unsaturated tetramers, revealing a unique enoxaparin signature and the structural relationship between non-reducing ends and biosynthesis of parent heparin. Additionally, glucosamine tetrasaccharides at the NRE may be associated with heparanase hydrolytic action, with high sulfation degree and 3-O-sulfation characteristic for both types of NRE.
CARBOHYDRATE POLYMERS
(2021)
Review
Cell Biology
Raheleh Farahzadi, Behnaz Valipour, Soheila Montazersaheb, Ezzatollah Fathi
Summary: Adult stem cells (ASCs) throughout the body can support tissue growth and repair. The function of stem cells is influenced by signals derived from their specific microenvironment or niche. Studies have shown that aging of the niche can lead to a decline in stem cell function and is associated with aging and age-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Ole Emil Andersen, Jens Vase Poulsen, Jean Farup, Antoine de Morree
Summary: Recent evidence suggests that dietary interventions and ketone body supplementation can impact adult stem cell function and have implications for regenerative medicine. This review discusses the mechanisms by which ketone bodies influence adult stem cells, including ketogenesis, uptake and transport, signaling, and cellular metabolism. The exploration of these mechanisms reveals potential therapeutic targets for tissue regeneration and age-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sa Cha, Sueng-Min Lee, Jiangyue Wang, Qing Zhao, Ding Bai
Summary: Aging is a major cause of TMJ disability and pain in older people. The circadian rhythm in TMJ structures changes significantly with age, affecting tissue structure and chondrogenesis capability. Bmal1-overexpressed BMSCs show potential in repairing age-related TMJ condylar degeneration, suggesting a promising clinical approach in tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Agriculture, Dairy & Animal Science
Yanmin Wang, Michael Alexander, Todd Scott, Desiree C. T. Cox, Augusta Wellington, Mike K. S. Chan, Michelle B. F. Wong, Orn Adalsteinsson, Jonathan R. T. Lakey
Summary: Companion animals often suffer from ailments that cannot be treated by conventional veterinary medicine. Stem cell therapy, with its regenerative potential, offers a new approach for treating these ailments by promoting local tissue regeneration and repair. This review aims to summarize the various uses of stem cells in treating age-related and joint diseases in companion animals.
Article
Cardiac & Cardiovascular Systems
Tim Stuedemann, Judith Roessinger, Christoph Manthey, Birgit Geertz, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Koehne, Antonius Wiehler, J. Simon Wiegert, Thomas Eschenhagen, Florian Weinberger
Summary: This study reveals the mechanism of how transplanted cardiomyocytes actively contribute to heart function, supporting the hypothesis that the delivery of new force-generating myocardium can serve as a regenerative therapeutic strategy.
Article
Cardiac & Cardiovascular Systems
Eva Querdel, Marina Reinsch, Liesa Castro, Deniz Kose, Andrea Bahr, Svenja Reich, Birgit Geertz, Barbel Ulmer, Mirja Schulze, Marc D. Lemoine, Tobias Krause, Marta Lemme, Jascha Sani, Aya Shibamiya, Tim Stuedemann, Maria Koehne, Constantin von Bibra, Nadja Hornaschewitz, Simon Pecha, Yusuf Nejahsie, Ingra Mannhardt, Torsten Christ, Hermann Reichenspurner, Arne Hansen, Nikolai Klymiuk, M. Krane, C. Kupatt, Thomas Eschenhagen, Florian Weinberger
Summary: The transplantation of engineered heart tissue (EHT) patches resulted in partial remuscularization of the injured heart and improved left ventricular function in a dose-dependent manner in guinea pig and pig models. Human-scale patches were successfully transplanted onto pigs in a proof-of-principle study.
Article
Veterinary Sciences
Sara J. Lawrence-Mills, David Hughes, Melanie J. Hezzell, Matthew Butler, Chris Neal, Rebecca R. Foster, Gavin I. Welsh, Natalie Finch
Summary: This review provides an overview of the structure, essential functions, and evidence for the role of the endothelial glycocalyx (eGlx) in disease. It highlights the lack of studies in cats and dogs and discusses techniques to aid its study in veterinary species.
VETERINARY JOURNAL
(2022)
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell & Tissue Engineering
Marco Tatullo
Summary: Aging is characterized by physiological changes that increase susceptibility to age-related diseases. This review summarizes the alterations affecting MSCs during aging and the role of inflammation in age-related syndromes.
Article
Engineering, Biomedical
Laurence Burroughs, Mahetab H. Amer, Matthew Vassey, Britta Koch, Grazziela P. Figueredo, Blessing Mukonoweshuro, Paulius Mikulskis, Aliaksei Vasilevich, Steven Vermeulen, Ian L. Dryden, David A. Winkler, Amir M. Ghaemmaghami, Felicity R. A. J. Rose, Jan de Boer, Morgan R. Alexander
Summary: In this study, a novel combinatorial chemistry-topography screening platform, the ChemoTopoChip, was used to identify materials suitable for bone regeneration by screening for human mesenchymal stem cell (hiMSCs) and human macrophage response. The results show that the materials selected through this platform can induce osteoinduction in hiMSCs and modulate macrophage phenotype, providing a materials-induced alternative to osteo-inductive supplements in bone-regeneration.
Review
Cell Biology
Soudeh Ghafouri-Fard, Vahid Niazi, Bashdar Mahmud Hussen, Mir Davood Omrani, Mohammad Taheri, Abbas Basiri
Summary: Extracellular vesicles play important roles in cell-cell communication, inflammation modulation, cell proliferation, and tissue regeneration, with advantages such as lower risk and easier production and storage compared to cell therapy. Particularly, exosomes derived from mesenchymal stem cells are introduced as a therapeutic option for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Anna Campanati, Monia Orciani, Andrea Marani, Mariangela Di Vincenzo, Simona Magi, Stamatios Gregoriou, Federico Diotallevi, Emanuela Martina, Giulia Radi, Annamaria Offidani
Summary: Atopic dermatitis is an inflammatory disease with IL4 and IL13 as major inflammatory mediators. Dupilumab, which can inhibit both interleukins, has shown promise in treating the disease. This study aimed to evaluate the efficacy of Dupilumab on MSCs immunobiology and found that IL13 plays a central role in the development of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jianrong Wang, Cristina Vicente-Garcia, Davide Seruggia, Eduardo Molto, Ana Fernandez-Minan, Ana Neto, Elbert Lee, Jose Luis Gomez-Skarmeta, Lluis Montoliu, Victoria V. Lunyak, I. King Jordan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Oncology
Ping Niu, Aibek Smagul, Lu Wang, Aiman Sadvakas, Ying Sha, Laura M. Perez, Aliya Nussupbekova, Aday Amirbekov, Akan A. Akanov, Beatriz G. Galvez, I. King Jordan, Victoria V. Lunyak
Review
Biochemistry & Molecular Biology
Meenakshi Gaur, Marek Dobke, Victoria V. Lunyak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cell Biology
Pedro Sousa-Victor, Arshad Ayyaz, Rippei Hayashi, Yanyan Qi, David T. Madden, Victoria V. Lunyak, Heinrich Jasper
Review
Genetics & Heredity
Victoria V. Lunyak, Alexandra Amaro-Ortiz, Meenakshi Gaur
FRONTIERS IN GENETICS
(2017)
Article
Cell Biology
Mary F. Lopez, James Tollervey, Bryan Krastins, Alejandra Garces, David Sarracino, Amol Prakash, Maryann Vogelsang, Glenn Geesman, Augusto Valderrama, King I. Jordan, Victoria V. Lunyak
Article
Biochemical Research Methods
Daudi Jjingo, Jianrong Wang, Andrew B. Conley, Victoria V. Lunyak, I. King Jordan
Article
Biochemical Research Methods
Jianrong Wang, Victoria V. Lunyak, I. King Jordan
Review
Biochemistry & Molecular Biology
James R. Tollervey, Victoria V. Lunyak
Review
Clinical Neurology
Yue-Qiang Zhao, I. King Jordan, Victoria V. Lunyak
Article
Biochemistry & Molecular Biology
Jianrong Wang, Victoria V. Lunyak, I. King Jordan
NUCLEIC ACIDS RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Jianrong Wang, Victoria V. Lunyak, I. King Jordan
NUCLEIC ACIDS RESEARCH
(2012)
Article
Genetics & Heredity
Daudi Jjingo, Andrew B. Conley, Jianrong Wang, Leonardo Marino-Ramirez, Victoria V. Lunyak, I. King Jordan
Article
Genetics & Heredity
Laura M. Perez, Beatriz de Lucas, Victoria V. Lunyak, Beatriz G. Galvez
MOLECULAR GENETICS AND METABOLISM REPORTS
(2017)
Article
Geriatrics & Gerontology
Mary F. Lopez, Ping Niu, Lu Wang, Maryann Vogelsang, Meenakshi Gaur, Bryan Krastins, Yueqiang Zhao, Aibek Smagul, Aliya Nussupbekova, Aikan A. Akanov, I. King Jordan, Victoria V. Lunyak
NPJ AGING AND MECHANISMS OF DISEASE
(2017)
