期刊
CELL CYCLE
卷 10, 期 11, 页码 1719-1725出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.11.15673
关键词
autophagy; mitophagy; Atg7; hematopoiesis; HSCs; myelodysplastic; syndrome; acute myeloid leukemia
类别
资金
- National Sciences and Engineering Council of Canada
- Nuffield Department of Medicine
- Det Frie Forskningsrad Sundhed og Sygdom (FSS)
- Wellcome Trust
- BBSRC
- NIHR
- BBSRC [BB/G021422/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G021422/1] Funding Source: researchfish
Autophagy is a conserved cellular pathway responsible for the sequestration of spent organelles and protein aggregates from the cytoplasm and their delivery into lysosomes for degradation. Autophagy plays an important role in adaptation to starvation, in cell survival, immunity, development and cancer. Recent evidence in mice suggests that autophagic defects in hematopoietic stem cells (HSCs) may be implicated in leukemia. Indeed, mice lacking Atg7 in HSCs develop an atypical myeloproliferation resembling human myelodysplastic syndrome (MDS) progressing to acute myeloid leukemia (AML). Our studies suggest that accumulation of damaged mitochondria and reactive oxygen species result in cell death of the majority of progenitor cells and, possibly, concomitant transformation of some surviving ones. Interestingly, bone marrow cells from MDS patients are characterized by mitochondrial abnormalities and increased cell death. A role for autophagy in the transformation to cancer has been proposed in other cancer types. This review focuses on autophagy in human MDS development and progression to AML within the context of the role of mitochondria, apoptosis and reactive oxygen species (ROS) in its pathogenesis.
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